DOI: 10.1002/pro.5560060128. SAM as a protein interaction domain involved in developmental regulation

SAM as a protein interaction domain involved in developmental regulation

10.1002/pro.5560060128

Crossref journal-article

Wiley

Protein Science (311)

Abstract

AbstractMore than 60 previously undetected SAM domain‐containing proteins have been identified using profile searching methods. Among these are over 40 EPH‐related receptor tyrosine kinases (RPTK), Drosophila bicaudal‐C, a p53 from Loligo forbesi, and diacylglycerol‐kinase isoform δ. This extended dataset suggests that SAM is an evolutionary conserved protein binding domain that is involved in the regulation of numerous developmental processes among diverse eukaryotes. A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell‐cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine.

Bibliography

Schultz, J., Bork, P., Ponting, C. P., & Hofmann, K. (1997). SAM as a protein interaction domain involved in developmental regulation. Protein Science, 6(1), 249â253. Portico.

Authors 4

Jörg Schultz (first)
Peer Bork (additional)
Christopher P. Ponting (additional)
Kay Hofmann (additional)

References 36 Referenced 242

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10.1242/dev.122.5.1621 / Development / The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein by Bomemann D (1996)
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{'key': 'e_1_2_1_18_1', 'first-page': '3645', 'article-title': 'Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors', 'volume': '54', 'author': 'Kiyokawa E', 'year': '1994', 'journal-title': 'Cancer Res'} / Cancer Res / Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors by Kiyokawa E (1994)
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{'key': 'e_1_2_1_36_1', 'first-page': '1573', 'article-title': 'Identification of full‐length and truncated forms of Ehk‐3, a novel member of the Eph receptor tyrosine kinase family', 'volume': '10', 'author': 'Valenzuela DM', 'year': '1995', 'journal-title': 'Oncogene'} / Oncogene / Identification of full‐length and truncated forms of Ehk‐3, a novel member of the Eph receptor tyrosine kinase family by Valenzuela DM (1995)
10.1038/381319a0

Dates

Type	When
Created	15 years, 1 month ago (July 12, 2010, 2:54 a.m.)
Deposited	1 year, 10 months ago (Oct. 28, 2023, 8:01 a.m.)
Indexed	2 weeks, 4 days ago (Aug. 19, 2025, 7:01 a.m.)
Issued	28 years, 8 months ago (Jan. 1, 1997)
Published	28 years, 8 months ago (Jan. 1, 1997)
Published Online	16 years, 8 months ago (Dec. 31, 2008)
Published Print	28 years, 8 months ago (Jan. 1, 1997)

Funders 0

None

BibTeX

@article{Schultz_1997, title={SAM as a protein interaction domain involved in developmental regulation}, volume={6}, ISSN={1469-896X}, url={http://dx.doi.org/10.1002/pro.5560060128}, DOI={10.1002/pro.5560060128}, number={1}, journal={Protein Science}, publisher={Wiley}, author={Schultz, Jörg and Bork, Peer and Ponting, Christopher P. and Hofmann, Kay}, year={1997}, month=jan, pages={249–253} }

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