DOI: 10.1002/pro.5560040801. The picornaviral 3C proteinases: Cysteine nucleophiles in serine proteinase folds

The picornaviral 3C proteinases: Cysteine nucleophiles in serine proteinase folds

10.1002/pro.5560040801

Crossref journal-article

Wiley

Protein Science (311)

Abstract

AbstractThe 3C proteinases are a novel group of cysteine proteinases with a serine proteinase‐like fold that are responsible for the bulk of polyprotein processing in the Picornaviridae. Because members of this viral family are to blame for several ongoing global pandemic problems (rhinovirus, hepatitis A virus) as well as sporadic outbreaks of more serious pathologies (poliovirus), there has been continuing interest over the last two decades in the development of antiviral therapies. The recent determination of the structure of two of the 3C proteinases by X‐ray crystallography opens the door for the application of the latest advances in computer‐assisted identification and design of anti‐proteinase therapeutic/chemoprophylactic agents.

Bibliography

Malcolm, B. A. (1995). The picornaviral 3C proteinases: Cysteine nucleophiles in serine proteinase folds. Protein Science, 4(8), 1439â1445. Portico.

Authors 1

Bruce A. Malcolm (first)

References 65 Referenced 57

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Dates

Type	When
Created	16 years, 6 months ago (Feb. 9, 2009, 10:02 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 12:38 p.m.)
Indexed	4 months, 2 weeks ago (April 8, 2025, 10:19 p.m.)
Issued	30 years ago (Aug. 1, 1995)
Published	30 years ago (Aug. 1, 1995)
Published Online	16 years, 7 months ago (Dec. 31, 2008)
Published Print	30 years ago (Aug. 1, 1995)

Funders 0

None

BibTeX

@article{Malcolm_1995, title={The picornaviral 3C proteinases: Cysteine nucleophiles in serine proteinase folds}, volume={4}, ISSN={1469-896X}, url={http://dx.doi.org/10.1002/pro.5560040801}, DOI={10.1002/pro.5560040801}, number={8}, journal={Protein Science}, publisher={Wiley}, author={Malcolm, Bruce A.}, year={1995}, month=aug, pages={1439–1445} }

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  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/pro.5560040801"
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  "ISSN": [
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  "subject": [],
  "container-title-short": "Protein Science",
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}