DOI: 10.1002/pro.5560021104. Comparison of conformational characteristics in structurally similar protein pairs

Comparison of conformational characteristics in structurally similar protein pairs

10.1002/pro.5560021104

Crossref journal-article

Wiley

Protein Science (311)

Abstract

AbstractAlthough it is known that three‐dimensional structure is well conserved during the evolutionary development of proteins, there have been few studies that consider other parameters apart from divergence of the main‐chain coordinates. In this study, we align the structures of 90 pairs of homologous proteins having sequence identities ranging from 5 to 100%. Their structures are compared as a function of sequence identity, including not only consideration of Cα coordinates but also accessibility, Ooi numbers, secondary structure, and side‐chain angles. We discuss how these properties change as the sequences become less similar. This will be of practical use in homology modeling, especially for modeling very distantly related or analogous proteins. We also consider how the average size and number of insertions and deletions vary as sequences diverge. This study presents further quantitative evidence that structure is remarkably well conserved in detail, as well as at the topological level, even when the sequences do not show similarity that is significant statistically.

Bibliography

Flores, T. P., Orengo, C. A., Moss, D. S., & Thornton, J. M. (1993). Comparison of conformational characteristics in structurally similar protein pairs. Protein Science, 2(11), 1811â1826. Portico.

Authors 4

T.P. Flores (first)
C.A. Orengo (additional)
D.S. Moss (additional)
J.M. Thornton (additional)

References 43 Referenced 141

Dates

Type	When
Created	16 years, 6 months ago (Feb. 9, 2009, 7:13 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 6:04 a.m.)
Indexed	1 year, 1 month ago (Aug. 3, 2024, 10:37 p.m.)
Issued	31 years, 10 months ago (Nov. 1, 1993)
Published	31 years, 10 months ago (Nov. 1, 1993)
Published Online	16 years, 8 months ago (Dec. 31, 2008)
Published Print	31 years, 10 months ago (Nov. 1, 1993)

Funders 0

None

BibTeX

@article{Flores_1993, title={Comparison of conformational characteristics in structurally similar protein pairs}, volume={2}, ISSN={1469-896X}, url={http://dx.doi.org/10.1002/pro.5560021104}, DOI={10.1002/pro.5560021104}, number={11}, journal={Protein Science}, publisher={Wiley}, author={Flores, T.P. and Orengo, C.A. and Moss, D.S. and Thornton, J.M.}, year={1993}, month=nov, pages={1811–1826} }

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