DOI: 10.1002/ppul.10381. Effect of long‐acting β<sub>2</sub> agonists on exacerbation rates of asthma in children

Effect of long‐acting β2 agonists on exacerbation rates of asthma in children

10.1002/ppul.10381

Crossref journal-article

Wiley

Pediatric Pulmonology (311)

Abstract

AbstractThe purpose of this analysis was to examine the effect of long‐acting β2‐adrenoceptor agonists (LABAs) on the asthma exacerbation rate in pediatric patients. Randomized controlled trials (RCT) that included the use of LABAs to treat symptoms of pediatric asthma in children on inhaled corticosteroids, that reported asthma exacerbation rates, and that were published as full papers in peer‐reviewed journals were retrieved from a search of the medical literature. Eight studies were identified that fulfilled these criteria. An exacerbation was defined as deterioration in a patient's asthma requiring a change in prescribed medication or not defined but reported as an asthma exacerbation or an asthma‐related hospitalization. Analysis of data from the eight studies revealed no apparent protection from an asthma exacerbation among children on a LABA compared to patients on comparator treatment. The relative risk of an asthma exacerbation for LABA compared to placebo or short‐acting β2‐adrenoceptor agonist (SABA) ranged from 0.95–1.86. The relative risk of hospitalization for asthma in patients treated with LABAs with regular maintenance with ICS ranged from 3.3–21.6 in the three studies that reported asthma‐related hospitalizations. The lack of evidence for the control of asthma exacerbations in children regularly using a LABA should bring into question its general use as add‐on therapy. Studies should be designed to directly explore the implications of these observations in pediatric patients. Pediatr Pulmonol. 2003; 36:391–398. © 2003 Wiley‐Liss, Inc.

Bibliography

Bisgaard, H. (2003). Effect of longâacting Î²2 agonists on exacerbation rates of asthma in children. Pediatric Pulmonology, 36(5), 391â398. Portico.

Authors 1

Hans Bisgaard (first)

References 28 Referenced 90

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Dates

Type	When
Created	21 years, 11 months ago (Sept. 26, 2003, 6:39 a.m.)
Deposited	1 year, 9 months ago (Nov. 17, 2023, 11:49 a.m.)
Indexed	5 days, 6 hours ago (Aug. 30, 2025, 1:15 p.m.)
Issued	21 years, 11 months ago (Sept. 25, 2003)
Published	21 years, 11 months ago (Sept. 25, 2003)
Published Online	21 years, 11 months ago (Sept. 25, 2003)
Published Print	21 years, 10 months ago (Nov. 1, 2003)

Funders 0

None

BibTeX

@article{Bisgaard_2003, title={Effect of long‐acting β2 agonists on exacerbation rates of asthma in children}, volume={36}, ISSN={1099-0496}, url={http://dx.doi.org/10.1002/ppul.10381}, DOI={10.1002/ppul.10381}, number={5}, journal={Pediatric Pulmonology}, publisher={Wiley}, author={Bisgaard, Hans}, year={2003}, month=sep, pages={391–398} }

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