DOI: 10.1002/path.1711740205. Expression of integrins and CD44 isoforms in non‐Hodgkin's lymphomas: CD44 variant isoforms are preferentially expressed in high‐grade malignant lymphomas

Expression of integrins and CD44 isoforms in non‐Hodgkin's lymphomas: CD44 variant isoforms are preferentially expressed in high‐grade malignant lymphomas

10.1002/path.1711740205

Crossref journal-article

Wiley

The Journal of Pathology (311)

Abstract

AbstractLow‐ and high‐grade malignant non‐Hodgkin's lymphomas have been investigated by immunohistochemistry for their expression of various integrins and CD44 isoforms. Comparison with the expression patterns obtained in non‐malignant adult lymph nodes revealed the following differences: α6 and β4 integrins were expressed in several high‐grade malignant lymphomas to a lower degree than in both the low‐grade malignant lymphomas and the normal lymph nodes; all other integrins (α2, α4, α5, αv, β1, β2, β3, and β7) did not exhibit significant differences in the expression levels between malignant and non‐malignant tissues. The standard isoform of CD44 (CD44s) was highly expressed in all lymphoid tissues. Using CD44 exon‐specific monoclonal antibodies, CD44 variant isoforms were not detected in non‐malignant lymph nodes and were detected only rarely in low‐grade malignant lymphomas. In contrast, high‐grade malignant lymphomas expressed several CD44 variant isoforms, which included the products from the variant exons 3v, 6v, and 9v, but not 4v. Specifically, detection of exon 3v and 6v products indicates a more aggressive phenotype.

Bibliography

Terpe, H., Koopmann, R., Imhof, B. A., & GÃ¼nthert, U. (1994). Expression of integrins and CD44 isoforms in nonâHodgkinâs lymphomas: CD44 variant isoforms are preferentially expressed in highâgrade malignant lymphomas. The Journal of Pathology, 174(2), 89â100. Portico.

Authors 4

Hans‐Joachim Terpe (first)
Rita Koopmann (additional)
Beat A. Imhof (additional)
Ursula Günthert (additional)

References 45 Referenced 43

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Dates

Type	When
Created	20 years, 2 months ago (June 22, 2005, 1:07 p.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 8:22 p.m.)
Indexed	11 months, 3 weeks ago (Sept. 5, 2024, 10:01 p.m.)
Issued	30 years, 11 months ago (Oct. 1, 1994)
Published	30 years, 11 months ago (Oct. 1, 1994)
Published Online	20 years, 2 months ago (June 15, 2005)
Published Print	30 years, 11 months ago (Oct. 1, 1994)

Funders 0

None

BibTeX

@article{Terpe_1994, title={Expression of integrins and CD44 isoforms in non‐Hodgkin’s lymphomas: CD44 variant isoforms are preferentially expressed in high‐grade malignant lymphomas}, volume={174}, ISSN={1096-9896}, url={http://dx.doi.org/10.1002/path.1711740205}, DOI={10.1002/path.1711740205}, number={2}, journal={The Journal of Pathology}, publisher={Wiley}, author={Terpe, Hans‐Joachim and Koopmann, Rita and Imhof, Beat A. and Günthert, Ursula}, year={1994}, month=oct, pages={89–100} }

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        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "2005-06-15",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}