DOI: 10.1002/path.1711650106. Low expression of β1, α2 and α3 subunits of VLA integrins in malignant mammary tumours

Low expression of β1, α2 and α3 subunits of VLA integrins in malignant mammary tumours

10.1002/path.1711650106

Crossref journal-article

Wiley

The Journal of Pathology (311)

Abstract

AbstractThe Very Late Antigens (VLAs) are αβ heterodimeric transmembrane proteins mediating cell–substratum as well as cell–cell interactions. Changes in their expression and/or function seem to occur in a number of invasive carcinomas and may at least in part explain their abnormal patterns of growth and differentiation. Using monoclonal antibodies to the β1 (DH12, A1A‐5), α2 (B1.515) and α3 (E1.56) chains, VLA‐2 (α2β1) and VLA‐3 (α3β1) were studied on cryostat sections of three fibroadenomas and 43 invasive breast carcinomas (29 ductal, 14 lobular) by the avidin–biotin complex immunoperioxidase technique. In non‐neoplastic breast tissue and in fibroadenomas VLA‐2 and VLA‐3 were expressed by myoepithelial cells and on the basolateral surface of the luminal cells. There was weak or absent expression of α2, α3 and the common β1 chain in the majority of invasive carcinomas compared to the adjacent normal breast epithelium and preinvasive (in‐situ) carcinomas. In addition, the expression of the α2 chain of VLA‐2 was reduced significantly (P < 0.005) in the poorly differentiated ductal breast carcinomas (Grade III) compared to the well (Grade I) and moderately (Grade II) differentiated ductal tumours. These data give further evidence that loss or down‐regulation of VLA‐2 and VLA‐3 occur relatively frequently in invasive cancers, and, at least in the invasive ductal breast carcinomas. Loss of an extracellular matrix receptor controlling growth and differentiation seems to be one of the abnormalities underlying the progression towards an undifferentiated morphology.

Bibliography

Pignatelli, M., Hanby, A. M., & Stamp, G. W. H. (1991). Low expression of Î²1, Î±2 and Î±3 subunits of VLA integrins in malignant mammary tumours. The Journal of Pathology, 165(1), 25â32. Portico.

Authors 3

Massimo Pignatelli (first)
Andrew M. Hanby (additional)
Gordon W. H. Stamp (additional)

References 30 Referenced 99

10.1146/annurev.iy.08.040190.002053
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{'key': 'e_1_2_1_5_2', 'first-page': '113', 'article-title': 'Widespread histologic distribution of the α2β1 integrin cell surface receptor', 'volume': '137', 'author': 'Zutter MM', 'year': '1990', 'journal-title': 'Am J Pathol'} / Am J Pathol / Widespread histologic distribution of the α2β1 integrin cell surface receptor by Zutter MM (1990)
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BissellMJ Barcellos‐HoffMH. The influence of extracellular matrix on gene expression: is structure the message?J Cell Sci1987; Suppl. 8 327–343. (10.1242/jcs.1987.Supplement_8.18)
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10.1111/j.1365-2559.1986.tb02497.x
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{'key': 'e_1_2_1_18_2', 'first-page': '300', 'volume-title': 'Diagnostic Histopathology of the Breast', 'author': 'Elston CW', 'year': '1987'} / Diagnostic Histopathology of the Breast by Elston CW (1987)
{'key': 'e_1_2_1_19_2', 'first-page': '26', 'volume-title': 'Pathology Reporting in Breast Cancer Screening', 'author': "Royal College of Pathologist's Working Group", 'year': '1990'} / Pathology Reporting in Breast Cancer Screening by Royal College of Pathologist's Working Group (1990)
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{'key': 'e_1_2_1_24_2', 'first-page': '863', 'article-title': 'Decreased expression of integr adhesive protein receptors in adenocarcinoma of the breast', 'volume': '137', 'author': 'Zutter MM', 'year': '1990', 'journal-title': 'Am Pathol'} / Am Pathol / Decreased expression of integr adhesive protein receptors in adenocarcinoma of the breast by Zutter MM (1990)
{'key': 'e_1_2_1_25_2', 'first-page': '511', 'article-title': 'Hormonal requirements for basement membrane collagen deposition by cultured rat mamma? epithelium', 'volume': '41', 'author': 'Liotta LA', 'year': '1979', 'journal-title': 'Lab Invest'} / Lab Invest / Hormonal requirements for basement membrane collagen deposition by cultured rat mamma? epithelium by Liotta LA (1979)
{'key': 'e_1_2_1_26_2', 'first-page': '1191', 'article-title': 'Generation of cell types with myoepithelial and mesenchyma phen? types during the conversion of rat mammary tumor epithelial ster? cells into elongated cells', 'volume': '78', 'author': 'Warburton MJ', 'year': '1987', 'journal-title': 'J Natl Cancer Inst'} / J Natl Cancer Inst / Generation of cell types with myoepithelial and mesenchyma phen? types during the conversion of rat mammary tumor epithelial ster? cells into elongated cells by Warburton MJ (1987)
{'key': 'e_1_2_1_27_2', 'first-page': '4763', 'article-title': 'Distribution ? myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases', 'volume': '42', 'author': 'Gusterson BA', 'year': '1982', 'journal-title': 'Cancer Res'} / Cancer Res / Distribution ? myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases by Gusterson BA (1982)
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10.1242/jcs.97.4.585
{'key': 'e_1_2_1_31_2', 'first-page': '6757', 'article-title': 'Integrin distribution in malignant melanoma; association of the β3 subunit with tumor progression', 'volume': '50', 'author': 'Albeda SM', 'year': '1990', 'journal-title': 'Cancer Res'} / Cancer Res / Integrin distribution in malignant melanoma; association of the β3 subunit with tumor progression by Albeda SM (1990)

Dates

Type	When
Created	20 years, 2 months ago (June 22, 2005, 10:22 a.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 11:57 p.m.)
Indexed	1 month, 2 weeks ago (July 14, 2025, 11:30 p.m.)
Issued	34 years ago (Sept. 1, 1991)
Published	34 years ago (Sept. 1, 1991)
Published Online	20 years, 2 months ago (June 16, 2005)
Published Print	34 years ago (Sept. 1, 1991)

Funders 0

None

BibTeX

@article{Pignatelli_1991, title={Low expression of β1, α2 and α3 subunits of VLA integrins in malignant mammary tumours}, volume={165}, ISSN={1096-9896}, url={http://dx.doi.org/10.1002/path.1711650106}, DOI={10.1002/path.1711650106}, number={1}, journal={The Journal of Pathology}, publisher={Wiley}, author={Pignatelli, Massimo and Hanby, Andrew M. and Stamp, Gordon W. H.}, year={1991}, month=sep, pages={25–32} }

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