DOI: 10.1002/path.1711640313. Histopathological studies on the local reactions induced by complete fReund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P<sub>3</sub>C) conjugates

Histopathological studies on the local reactions induced by complete fReund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates

10.1002/path.1711640313

Crossref journal-article

Wiley

The Journal of Pathology (311)

Abstract

AbstractThe inflammatory reactions following subcutaneous application of adjuvants revealed characteristic pathological patterns. The injection of complete Freund's adjuvant (CFA) resulted in the formation of large lipid deposits encircled by an inflammatory reaction and concentrically arranged collagen bundles. Bacterial lipopolysaccharide (LPS) caused granulomatous aggregations of mononuclear cells with thrombotic vessel occlusions. Inoculation of the lipopeptide adjuvants induced accumulation of mononculear cells with only minimal fibrotic changes which were resolved after day 28. Lipopeptide conjugates based on the head group tripalmitoyl‐S‐glyceryl‐cysteinyl‐serin (P3CS) can thus be used as effective immunogens and adjuvants without long‐term tissue damage.

Bibliography

Wiedemann, F., Link, R., Pumpe, K., Jacobshagen, U., Schaefer, H. E., WiesmÃ¼ller, K., Hummel, R., Jung, G., Bessler, W., & BÃ¶ltz, T. (1991). Histopathological studies on the local reactions induced by complete fReundâs adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates. The Journal of Pathology, 164(3), 265â271. Portico.

Authors 10

Frank Wiedemann (first)
Ralf Link (additional)
Konrad Pumpe (additional)
Ulrich Jacobshagen (additional)
Hans E. Schaefer (additional)
Karl‐Heinz Wiesmüller (additional)
Rolf‐Peter Hummel (additional)
Günther Jung (additional)
Wolfgang Bessler (additional)
Traudel Böltz (additional)

References 23 Referenced 52

10.1016/0022-1759(83)90220-X
10.1016/0167-5699(87)90827-9
10.1016/0167-5699(87)90239-8
10.1016/S0769-2625(85)80113-6
10.4049/jimmunol.141.5.1720
Immunological adjuvants. WHO Tech Rep Ser1976; No. 595.
10.4049/jimmunol.135.3.1900
10.1515/bchm2.1983.364.1.593
10.4049/jimmunol.137.8.2676
10.1002/anie.198508721
10.1016/S0171-2985(85)80095-4
10.1016/0264-410X(89)90007-8
10.1002/bip.360280144
10.1038/342561a0
10.1073/pnas.83.16.6159
{'key': 'e_1_2_1_17_2', 'first-page': '130', 'article-title': 'The mode of action of immunologic adjuvants', 'volume': '7', 'author': 'Freund J', 'year': '1956', 'journal-title': 'Adv Tuberc Res'} / Adv Tuberc Res / The mode of action of immunologic adjuvants by Freund J (1956)
{'key': 'e_1_2_1_18_2', 'first-page': '146', 'article-title': 'Mineral oil adjuvants: biological and chemical studies', 'volume': '30', 'author': 'Murray R', 'year': '1972', 'journal-title': 'Ann Allergy'} / Ann Allergy / Mineral oil adjuvants: biological and chemical studies by Murray R (1972)
{'key': 'e_1_2_1_19_2', 'first-page': '63', 'article-title': 'Biological activities of muramyl dipeptide, a synthetic glycopeptide analogue to bacterial immunoregulating agents', 'volume': '25', 'author': 'Chedid L', 'year': '1978', 'journal-title': 'Prog Allergy'} / Prog Allergy / Biological activities of muramyl dipeptide, a synthetic glycopeptide analogue to bacterial immunoregulating agents by Chedid L (1978)
10.1016/S0171-2985(88)80036-6
10.1515/bchm3.1989.370.1.575
10.1002/path.1711320306
{'key': 'e_1_2_1_23_2', 'first-page': '125', 'article-title': 'Histopathological tests of tissue in the sites of local reactions caused by the injection of oil‐adjuvant cholera vaccine', 'volume': '6', 'author': 'Ogonuki H', 'year': '1967', 'journal-title': 'Symp Ser Immunobiol Stan'} / Symp Ser Immunobiol Stan / Histopathological tests of tissue in the sites of local reactions caused by the injection of oil‐adjuvant cholera vaccine by Ogonuki H (1967)
10.1016/S0140-6736(88)90616-2

Dates

Type	When
Created	20 years, 2 months ago (June 22, 2005, 10:20 a.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 12:19 a.m.)
Indexed	5 months ago (March 28, 2025, 7:01 a.m.)
Issued	34 years, 1 month ago (July 1, 1991)
Published	34 years, 1 month ago (July 1, 1991)
Published Online	20 years, 2 months ago (June 15, 2005)
Published Print	34 years, 1 month ago (July 1, 1991)

Funders 0

None

BibTeX

@article{Wiedemann_1991, title={Histopathological studies on the local reactions induced by complete fReund’s adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates}, volume={164}, ISSN={1096-9896}, url={http://dx.doi.org/10.1002/path.1711640313}, DOI={10.1002/path.1711640313}, number={3}, journal={The Journal of Pathology}, publisher={Wiley}, author={Wiedemann, Frank and Link, Ralf and Pumpe, Konrad and Jacobshagen, Ulrich and Schaefer, Hans E. and Wiesmüller, Karl‐Heinz and Hummel, Rolf‐Peter and Jung, Günther and Bessler, Wolfgang and Böltz, Traudel}, year={1991}, month=jul, pages={265–271} }

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