DOI: 10.1002/path.1711570304. Expression of the nuclear oncogene p53 in colon tumours

Expression of the nuclear oncogene p53 in colon tumours

10.1002/path.1711570304

Crossref journal-article

Wiley

The Journal of Pathology (311)

Abstract

AbstractThe nuclear tumour antigen p53 is expressed by a gene localized on the p‐arm of human chromosome 17, a region frequently deleted in colon carcinomas. Using a monoclonal antibody to p53 antigen, immunohistochemical analysis of carcinomas and dysplastic tubular adenomas of the colon has been performed to study the relation between p53 expression and dysplasia or malignancy. With this methods p53 was detectable in 55 per cent of colon carcinomas (n = 29).In 8 per cent of adenomas (n = 74), focal nuclear p53 expression was found in dysplastic epithelial cells. In general, these p53‐positive regions of the polyps were histologically indistinguishable from the neighbouring tubuli. Sometimes the p53‐positive nuclei were found in a focus of more highly dysplastic epithelium. The results suggest that expression of the p53 gene may be part of the process of malignant transformation of dysplastic colon polyps.

Bibliography

Van Den Berg, F. M., Tigges, A. J., Schipper, M. E. I., Den HartogâJager, F. C. A., Kroes, W. G. M., & Walboomers, J. M. M. (1989). Expression of the nuclear oncogene p53 in colon tumours. The Journal of Pathology, 157(3), 193â199. Portico.

Authors 6

F. M. Van Den Berg (first)
A. J. Tigges (additional)
M. E. I. Schipper (additional)
F. C. A. Den Hartog‐Jager (additional)
W. G. M. Kroes (additional)
J. M. M. Walboomers (additional)

References 21 Referenced 122

10.1038/278261a0
{'key': 'e_1_2_1_3_2', 'volume-title': 'The Transformation Associated Cellular p53 Protein', 'author': 'Klein G', 'year': '1982'} / The Transformation Associated Cellular p53 Protein by Klein G (1982)
{'key': 'e_1_2_1_4_2', 'first-page': '67', 'article-title': 'The p53 cellular tumour antigen: gene structure, expression and protein properties', 'volume': '823', 'author': 'Ohren M', 'year': '1985', 'journal-title': 'Biochim Biophys Acta'} / Biochim Biophys Acta / The p53 cellular tumour antigen: gene structure, expression and protein properties by Ohren M (1985)
10.1073/pnas.78.3.1695
10.1073/pnas.79.20.6309
10.1016/0092-8674(84)90532-4
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10.1073/pnas.83.11.4035
10.1038/311562a0
10.1038/328614a0
10.1002/ijc.2910280407
10.1016/0165-4608(87)90302-5
10.1126/science.2889267
10.1038/320084a0
{'key': 'e_1_2_1_16_2', 'first-page': '615', 'article-title': 'Oncogenic transformation of primary rat kidney cells by DNA of herpes simplex virus type 2', 'volume': '85', 'author': 'Walboomers JMM', 'year': '1982', 'journal-title': 'Proc K Ned A Sci'} / Proc K Ned A Sci / Oncogenic transformation of primary rat kidney cells by DNA of herpes simplex virus type 2 by Walboomers JMM (1982)
10.1128/jvi.39.3.861-869.1981
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{'key': 'e_1_2_1_20_2', 'first-page': '615', 'volume-title': 'Gastro‐intestinal Pathology', 'author': 'Morson BC', 'year': '1979'} / Gastro‐intestinal Pathology by Morson BC (1979)
10.1016/0304-419X(86)90024-7
10.1038/bjc.1986.1

Dates

Type	When
Created	20 years, 2 months ago (June 22, 2005, 9:35 a.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 11:25 a.m.)
Indexed	6 days, 23 hours ago (Aug. 19, 2025, 7 a.m.)
Issued	36 years, 5 months ago (March 1, 1989)
Published	36 years, 5 months ago (March 1, 1989)
Published Online	20 years, 2 months ago (June 16, 2005)
Published Print	36 years, 5 months ago (March 1, 1989)

Funders 0

None

BibTeX

@article{Van_Den_Berg_1989, title={Expression of the nuclear oncogene p53 in colon tumours}, volume={157}, ISSN={1096-9896}, url={http://dx.doi.org/10.1002/path.1711570304}, DOI={10.1002/path.1711570304}, number={3}, journal={The Journal of Pathology}, publisher={Wiley}, author={Van Den Berg, F. M. and Tigges, A. J. and Schipper, M. E. I. and Den Hartog‐Jager, F. C. A. and Kroes, W. G. M. and Walboomers, J. M. M.}, year={1989}, month=mar, pages={193–199} }

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