DOI: 10.1002/path.1711390203. The ultrastructural localisation of de‐nol (colloidal tripotassium dicitrato‐bismuthate—TDB) in the upper gastrointestinal tract of man and rodents following oral and instrumental administration

The ultrastructural localisation of de‐nol (colloidal tripotassium dicitrato‐bismuthate—TDB) in the upper gastrointestinal tract of man and rodents following oral and instrumental administration

10.1002/path.1711390203

Crossref journal-article

Wiley

The Journal of Pathology (311)

Abstract

AbstractIn the presence of hydrochloric acid, tripotassium dicitrato‐bismuthate forms a particulate precipitate which is electron dense. In upper gastrointestinal tract endoscopic biopsies, following a single oral dose, precipitate was detected between superficial oesophageal epithelial cells and also lining lipid droplets within oesophageal cells. The precipitate does not appear to penetrate the thick mucus barrier in the normal stomach but reaches the epithelial cell surface in the duodenum and proximal jejunum. Small particles of bismuth complex are endocytosed by the enterocyte and enter multivesicular bodies. A similar series of events was observed in rodents and an approximate time course for adsoprtion and endocytosis was estimated.

Bibliography

Coghill, S. B., Hopwood, D., McPherson, S., & Hislop, S. (1983). The ultrastructural localisation of deânol (colloidal tripotassium dicitratoâbismuthateâTDB) in the upper gastrointestinal tract of man and rodents following oral and instrumental administration. The Journal of Pathology, 139(2), 105â114. Portico.

Authors 4

S. B. Coghill (first)
D. Hopwood (additional)
S. McPherson (additional)
S. Hislop (additional)

References 15 Referenced 31

10.1007/BF00533129
10.2165/00003495-197612060-00001
{'key': 'e_1_2_1_4_1', 'first-page': '877', 'article-title': "20 Observations d'encephalopathies aiguesavec myoclonies au cours treatment oraux par les sel de bismuth", 'volume': '125', 'author': 'Buge A.', 'year': '1975', 'journal-title': 'Annale Medicine Interne.'} / Annale Medicine Interne. / 20 Observations d'encephalopathies aiguesavec myoclonies au cours treatment oraux par les sel de bismuth by Buge A. (1975)
10.1136/bmj.1.5901.220
10.1016/0002-9343(64)90137-8
10.1007/BF02899143
10.1002/path.1711360204
10.1016/S0140-6736(76)90786-8
{'key': 'e_1_2_1_10_1', 'first-page': '779', 'article-title': 'An endoscopic evaluation of gastric ulcer treated with bismuth ammonium citrate', 'volume': '12', 'author': 'Lanza F. L.', 'year': '1970', 'journal-title': 'Current Therapeutic Research'} / Current Therapeutic Research / An endoscopic evaluation of gastric ulcer treated with bismuth ammonium citrate by Lanza F. L. (1970)
10.1111/j.1440-1681.1980.tb00076.x
{'key': 'e_1_2_1_12_1', 'volume-title': 'Trace elements in human health and disease', 'author': 'Spivey‐Fox M. R.', 'year': '1976'} / Trace elements in human health and disease by Spivey‐Fox M. R. (1976)
{'key': 'e_1_2_1_13_1', 'first-page': '634', 'article-title': 'Ultrastructural changes in gastric ulcers after bicitropeptide and cimetidine treatment', 'volume': '58', 'author': 'Theron T. T.', 'year': '1980', 'journal-title': 'S. A. Med. J.'} / S. A. Med. J. / Ultrastructural changes in gastric ulcers after bicitropeptide and cimetidine treatment by Theron T. T. (1980)
{'key': 'e_1_2_1_14_1', 'first-page': '317', 'article-title': 'A pilot trial of colloidal bismuth in the treatment of peptic ulcer', 'volume': '42', 'author': 'Weiss G.', 'year': '1968', 'journal-title': 'S. A. Med. J.'} / S. A. Med. J. / A pilot trial of colloidal bismuth in the treatment of peptic ulcer by Weiss G. (1968)
10.1016/0022-1902(77)80600-3
{'issue': '5', 'key': 'e_1_2_1_16_1', 'first-page': '18', 'article-title': 'The pharmacology of tripotassium dicitrato bismuthate (TDB)', 'volume': '51', 'author': 'Wilson T. R.', 'year': '1975', 'journal-title': 'Postgrad. Med. J.'} / Postgrad. Med. J. / The pharmacology of tripotassium dicitrato bismuthate (TDB) by Wilson T. R. (1975)

Dates

Type	When
Created	20 years, 2 months ago (June 21, 2005, 2:46 p.m.)
Deposited	1 year, 10 months ago (Oct. 20, 2023, 8:38 a.m.)
Indexed	1 year, 9 months ago (Nov. 21, 2023, 3:22 p.m.)
Issued	42 years, 7 months ago (Feb. 1, 1983)
Published	42 years, 7 months ago (Feb. 1, 1983)
Published Online	20 years, 2 months ago (June 16, 2005)
Published Print	42 years, 7 months ago (Feb. 1, 1983)

Funders 0

None

BibTeX

@article{Coghill_1983, title={The ultrastructural localisation of de‐nol (colloidal tripotassium dicitrato‐bismuthate—TDB) in the upper gastrointestinal tract of man and rodents following oral and instrumental administration}, volume={139}, ISSN={1096-9896}, url={http://dx.doi.org/10.1002/path.1711390203}, DOI={10.1002/path.1711390203}, number={2}, journal={The Journal of Pathology}, publisher={Wiley}, author={Coghill, S. B. and Hopwood, D. and McPherson, S. and Hislop, S.}, year={1983}, month=feb, pages={105–114} }

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