DOI: 10.1002/neu.480280404. Gap junctions are required for the propagation of spreading depression

Gap junctions are required for the propagation of spreading depression

10.1002/neu.480280404

Crossref journal-article

Wiley

Journal of Neurobiology (311)

Abstract

AbstractSpreading depression (SD) is a slowly propagating depression of cerebral neuronal activity and transmembrance ionic gradients, that arises in response to a variety of noxious stimuli. SD bears a strong resemblance to gap junction‐mediated calcium waves among cultured astrocytes. Here, we show that gap junction‐mediated intercellular diffusion is necessary for the generation of SD. Waves of SD in the isolated chicken retina were blocked by five different inhibitors of gap junctional coupling, which was assessed by the intercellular transit of Lucifer Yellow (LY). Each of these gap junction blockers inhibited both the migration of SD and the diffusion of LY in a dose‐dependent manner. In contrast, glutamate‐evoked calcium influx into retinal cells was not affected by these compounds. The results indicate that intercellular coupling through gap junctions is required for SD. Gap junction‐mediated communication might therefore constitute an important mechanism in both normative and pathological brain function. © 1995 John Wiley & Sons, Inc.

Bibliography

Nedergaard, M., Cooper, A. J. L., & Goldman, S. A. (1995). Gap junctions are required for the propagation of spreading depression. Journal of Neurobiology, 28(4), 433â444. Portico.

Authors 3

Maiken Nedergaard (first)
Arthur J. L. Cooper (additional)
Steven A. Goldman (additional)

References 55 Referenced 157

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Dates

Type	When
Created	20 years, 3 months ago (May 27, 2005, 5:40 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 7:54 p.m.)
Indexed	1 week ago (Aug. 31, 2025, 6:27 a.m.)
Issued	29 years, 9 months ago (Dec. 1, 1995)
Published	29 years, 9 months ago (Dec. 1, 1995)
Published Online	20 years, 10 months ago (Oct. 11, 2004)
Published Print	29 years, 9 months ago (Dec. 1, 1995)

Funders 0

None

BibTeX

@article{Nedergaard_1995, title={Gap junctions are required for the propagation of spreading depression}, volume={28}, ISSN={1097-4695}, url={http://dx.doi.org/10.1002/neu.480280404}, DOI={10.1002/neu.480280404}, number={4}, journal={Journal of Neurobiology}, publisher={Wiley}, author={Nedergaard, Maiken and Cooper, Arthur J. L. and Goldman, Steven A.}, year={1995}, month=dec, pages={433–444} }

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