DOI: 10.1002/neu.480251105. Activity‐dependent and hormonal regulation of neurotrophin mRNA levels in brain

Activity‐dependent and hormonal regulation of neurotrophin mRNA levels in brain–implications for neuronal plasticity

10.1002/neu.480251105

Crossref journal-article

Wiley

Journal of Neurobiology (311)

Abstract

AbstractThe neurotrophins exhibit neurotrophic effects on specific, partially overlapping populations of neurons both in the peripheral and the central nervous system (CNS). In the periphery, they are synthesized by a variety of nonneuronal cells, and their synthesis seems to be independent of the neuronal input. In contrast, in the CNS all neurotrophins are expressed under physiological conditions primarily by neurons. The production of NGF and BDNF is controlled by neuronal activity: up‐regulation by glutamate and acetylcholine, down‐regulation by gamma‐aminobutyric acid. In contrast, NT‐3 regulation is independent of neuronal activity, but it is up‐regulated by thyroid hormones and BDNF. The latter observation suggests that NT‐3 might be controlled indirectly by neuronal activity via BDNF. In peripheral nonneuronal tissues, glucocorticoid hormones down‐regulate NGF mRNA levels both in vitro and in vivo. In contrast, in the CNS, neuronal production of NGF is enhanced by glucocorticoids. The rapid regulation of NGF and BDNF by subtle physiological stimuli together with the recent demonstration that the neurotrophin release neurotransmitters such as acetylcholine opens up interesting perspectives for the function of neurotrophins as mediators of neuronal plasticity. 1994 John Wiley & Sons, Inc.

Bibliography

Lindholm, D., CastrÃ©n, E., Berzaghi, M., BlÃ¶chl, A., & Thoenen, H. (1994). Activityâdependent and hormonal regulation of neurotrophin mRNA levels in brainâimplications for neuronal plasticity. Journal of Neurobiology, 25(11), 1362â1372. Portico.

Authors 5

Dan Lindholm (first)
Eero Castrén (additional)
Maria Berzaghi (additional)
Andrea Blöchl (additional)
Hans Thoenen (additional)

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Dates

Type	When
Created	20 years, 7 months ago (Dec. 31, 2004, 10:42 p.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 9:52 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 1:25 a.m.)
Issued	30 years, 9 months ago (Nov. 1, 1994)
Published	30 years, 9 months ago (Nov. 1, 1994)
Published Online	20 years, 10 months ago (Oct. 11, 2004)
Published Print	30 years, 9 months ago (Nov. 1, 1994)

Funders 0

None

BibTeX

@article{Lindholm_1994, title={Activity‐dependent and hormonal regulation of neurotrophin mRNA levels in brain–implications for neuronal plasticity}, volume={25}, ISSN={1097-4695}, url={http://dx.doi.org/10.1002/neu.480251105}, DOI={10.1002/neu.480251105}, number={11}, journal={Journal of Neurobiology}, publisher={Wiley}, author={Lindholm, Dan and Castrén, Eero and Berzaghi, Maria and Blöchl, Andrea and Thoenen, Hans}, year={1994}, month=nov, pages={1362–1372} }

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