Abstract
AbstractCytoplasmic dynein has long been thought to be responsible for retrograde axonal transport. As the number of cellular roles for this multifunctional protein has expanded, the complexity of its contribution to axonal transport has increased. In this article the increasing evidence for a role for cytoplasmic dynein in anterograde as well as retrograde transport is discussed. The current status of the complex dynein cargo‐binding mechanism is evaluated. Finally, recent genetic evidence supporting a role in axonal transport and revealing a role in neurodegenerative conditions is reviewed. © 2003 Wiley Periodicals, Inc. J Neurobiol 58: 189–200, 2004
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{'key': 'e_1_2_1_99_1', 'first-page': '130a', 'article-title': 'Assembly of pericentrin and gamma tubulin at the centrosome is dynein‐mediated and required for normal spindle organization', 'volume': '9', 'author': 'Young A', 'year': '1998', 'journal-title': 'Mol Biol Cell'}
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Dates
Type | When |
---|---|
Created | 21 years, 8 months ago (Dec. 31, 2003, 4:35 a.m.) |
Deposited | 1 year, 11 months ago (Sept. 12, 2023, 8:16 p.m.) |
Indexed | 3 months, 3 weeks ago (May 9, 2025, 6:06 a.m.) |
Issued | 21 years, 8 months ago (Dec. 30, 2003) |
Published | 21 years, 8 months ago (Dec. 30, 2003) |
Published Online | 21 years, 8 months ago (Dec. 30, 2003) |
Published Print | 21 years, 7 months ago (Feb. 1, 2004) |
@article{Vallee_2003, title={Dynein: An ancient motor protein involved in multiple modes of transport}, volume={58}, ISSN={1097-4695}, url={http://dx.doi.org/10.1002/neu.10314}, DOI={10.1002/neu.10314}, number={2}, journal={Journal of Neurobiology}, publisher={Wiley}, author={Vallee, Richard B. and Williams, John C. and Varma, Dileep and Barnhart, Lora E.}, year={2003}, month=dec, pages={189–200} }