DOI: 10.1002/neu.10181. Estradiol initially enhances but subsequently suppresses (via adrenal steroids) granule cell proliferation in the dentate gyrus of adult female rats

Estradiol initially enhances but subsequently suppresses (via adrenal steroids) granule cell proliferation in the dentate gyrus of adult female rats

10.1002/neu.10181

Crossref journal-article

Wiley

Journal of Neurobiology (311)

Abstract

AbstractIn the dentate gyrus of adult female meadow voles, a high dose of estradiol benzoate (EB) increases (within 4 h) then decreases (within 48) the number of dividing progenitor cells (Ormerod BK, Galea LAM. 2001. Reproductive status regulates cell proliferation within the dentate gyrus of the adult female meadow vole: A possible regulatory role for estradiol. Neurosci 2:169–179). We investigated whether time‐dependent EB exposure differentially influences the number of new granule cells produced in the adult female rat dentate gyrus and whether EB‐stimulated adrenal activity mediates the decrease in cell proliferation. Ovariectomized rats received either an EB (10 μg in 0.1 mL) or vehicle (0.1 mL) injection either 4 or 48 h (Experiment 1) before a BrdU injection (200 mg/kg) and were perfused 24 h later to assess the number of new cells. Relative to vehicle, the number of new cells increased following a 4 h exposure (p ≤ 0.04) but decreased following a 48 h exposure (p ≤ 0.006) to EB. In Experiment 2, the number of new cells within the dentate gyrus of ovariectomized and adrenalectomized females did not significantly differ between groups exposed to EB versus vehicle for 48 h prior to BrdU administration, suggesting the decreased number of new cells observed within the dentate gyrus of adrenal‐intact adult female rats is mediated by EB‐stimulated adrenal activity. We conclude that estradiol dynamically regulates cell proliferation within the dentate gyrus of adult female rats in the time‐dependent manner observed previously in voles and suppresses cell proliferation by influencing adrenal steroids. Investigating how estradiol dynamically regulates neurogenesis could provide insight into the mechanisms by which the proliferation of progenitor cells is controlled within the adult rodent hippocampus. © 2003 Wiley Periodicals, Inc. J Neurobiol 55: 247–260, 2003

Bibliography

Ormerod, B. K., Lee, T. T., & Galea, L. A. M. (2003). Estradiol initially enhances but subsequently suppresses (via adrenal steroids) granule cell proliferation in the dentate gyrus of adult female rats. Journal of Neurobiology, 55(2), 247â260. Portico.

Authors 3

B. K. Ormerod (first)
T. T‐Y. Lee (additional)
L. A. M. Galea (additional)

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Dates

Type	When
Created	22 years, 5 months ago (March 28, 2003, 3:15 a.m.)
Deposited	1 year, 11 months ago (Sept. 28, 2023, 5:47 a.m.)
Indexed	1 month ago (July 30, 2025, 10:39 a.m.)
Issued	22 years, 5 months ago (March 4, 2003)
Published	22 years, 5 months ago (March 4, 2003)
Published Online	22 years, 5 months ago (March 4, 2003)
Published Print	22 years, 3 months ago (May 1, 2003)

Funders 0

None

BibTeX

@article{Ormerod_2003, title={Estradiol initially enhances but subsequently suppresses (via adrenal steroids) granule cell proliferation in the dentate gyrus of adult female rats}, volume={55}, ISSN={1097-4695}, url={http://dx.doi.org/10.1002/neu.10181}, DOI={10.1002/neu.10181}, number={2}, journal={Journal of Neurobiology}, publisher={Wiley}, author={Ormerod, B. K. and Lee, T. T‐Y. and Galea, L. A. M.}, year={2003}, month=mar, pages={247–260} }

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