DOI: 10.1002/mrm.1910380503. Brain MRI with laser‐polarized <sup>129</sup>xe

10.1002/mrm.1910380503

Crossref journal-article

Wiley

Magnetic Resonance in Medicine (311)

Abstract

AbstractThe feasibility of brain MRI with laser‐polarized 129Xe in a small animal model is demonstrated. Naturally abundant 129Xe is polarized and introduced into the lungs of Sprague‐Dawley rats. Polarized xenon gas dissolves in the blood and is transported to the brain where it accumulates in brain tissue. Spectroscopic studies reveal a single, dominant, tissue‐phase NMR resonance in the head at 194.5 ppm relative to the gas phase resonance. Images of 129Xe in the rat head were obtained with 98‐μl voxels by 2D chemical shift imaging and show that xenon is localized to the brain. This work establishes that nuclear polarization produced in the gas phases survives transport to the brain where it may be imaged. Increases in polarization and delivered volume of 129Xe will allow clinical measurements of regional cerebral blood flow.

Bibliography

Swanson, S. D., Rosen, M. S., Agranoff, B. W., Coulter, K. P., Welsh, R. C., & Chupp, T. E. (1997). Brain MRI with laserâpolarized 129xe. Magnetic Resonance in Medicine, 38(5), 695â698. Portico.

Authors 6

Scott D. Swanson (first)
Matthew S. Rosen (additional)
Bernard W. Agranoff (additional)
Kevin P. Coulter (additional)
Robert C. Welsh (additional)
Timothy E. Chupp (additional)

References 28 Referenced 149

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J. P. I. I. I.Mugler B.Driehuys J. R.Brookeman G. D.Cates S. S.Berr R. G.Bryant T. M.Daniel E. E.de Lange C. J.Erickson W.Happer D. P.Hinton T.Maier B. T.Saam K. L.Sauer M. E.Wagshul MR imaging of the human lungs using hyperpolarized129Xe gas in“Proc. ISMRM 5th Annual Meeting Vancouver 1997 ” p.2113.
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{'key': 'e_1_2_1_9_2', 'first-page': '1', 'article-title': 'The theory and application of the exchange of inert gas at the lung tissue', 'volume': '3', 'author': 'Kety S. S.', 'year': '1951', 'journal-title': 'Pharmacol. Rev.'} / Pharmacol. Rev. / The theory and application of the exchange of inert gas at the lung tissue by Kety S. S. (1951)
{'key': 'e_1_2_1_10_2', 'first-page': '144', 'volume-title': 'Cerebral Metabolism and Neural Function', 'author': 'Lassen N. A.', 'year': '1980'} / Cerebral Metabolism and Neural Function by Lassen N. A. (1980)
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Dates

Type	When
Created	18 years, 5 months ago (March 13, 2007, 4:37 a.m.)
Deposited	1 year, 10 months ago (Oct. 27, 2023, 9:34 p.m.)
Indexed	4 months, 1 week ago (April 22, 2025, 2:27 a.m.)
Issued	27 years, 10 months ago (Nov. 1, 1997)
Published	27 years, 10 months ago (Nov. 1, 1997)
Published Online	19 years, 8 months ago (Dec. 12, 2005)
Published Print	27 years, 10 months ago (Nov. 1, 1997)

Funders 0

None

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