DOI: 10.1002/mrm.1910360204. Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized <sup>3</sup>He

Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized 3He

10.1002/mrm.1910360204

Crossref journal-article

Wiley

Magnetic Resonance in Medicine (311)

Abstract

AbstractThe nuclear spin polarization of noble gases can be enhanced strongly by laser optical pumping followed by electron‐nuclear polarization transfer. Direct optical pumping of metastable 3He atoms has been shown to produce enormous polarization on the order of 0.4–0.6. This is about 105 times larger than the polarization of water protons at thermal equilibrium used in conventional MRI. We demonstrate that hyper‐polarized 3He gas can be applied to nuclear magnetic resonance imaging of organs with air‐filled spaces in humans. In vivo 3He MR experiments were performed in a whole‐body MR scanner with a superconducting magnet ramped down to 0.8 T. Anatomical details of the upper respiratory tract and of the lungs of a volunteer were visualized with the FLASH technique demonstrating the potential of the method for fast imaging of airways in the human body and for pulmonary ventilation studies.

Bibliography

Bachert, P., Schad, L. R., Bock, M., Knopp, M. V., Ebert, M., Grobmann, T., Heil, W., Hofmann, D., Surkau, R., & Otten, E. W. (1996). Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized 3He. Magnetic Resonance in Medicine, 36(2), 192â196. Portico.

Authors 10

Peter Bachert (first)
Lothar R. Schad (additional)
Michael Bock (additional)
Michael V. Knopp (additional)
Michael Ebert (additional)
Tino Grobmann (additional)
Werner Heil (additional)
Dirk Hofmann (additional)
Reinhard Surkau (additional)
Ernst W. Otten (additional)

References 18 Referenced 128

10.1148/radiology.179.3.2027991
10.1148/radiology.153.3.6494470
C. W.Li W.Negendank P.O'Dwyer K.Padavic‐Shaller J.Murphy‐Boesch T. R.Brown MRI‐directed 3D‐CSI‐localized19F MRS of fluorouracil catabolism in human liver in“Proc. SMR 2nd Annual Meeting San Francisco 1994 ” p.1303.
{'key': 'e_1_2_1_5_2', 'volume-title': 'The Nuclear Overhauser Effect in Structural and Conformational Analysis', 'author': 'Neuhaus D.', 'year': '1989'} / The Nuclear Overhauser Effect in Structural and Conformational Analysis by Neuhaus D. (1989)
10.1103/PhysRevLett.5.373
10.1103/PhysRevLett.49.25
10.1103/PhysRevA.29.3092
10.1103/PhysRevA.45.4631
10.1103/PhysRev.132.2561
10.1016/0168-9002(92)90769-Z
10.1016/0168-9002(94)90687-4
10.1016/0375-9601(95)00243-V
10.1016/S0140-6736(96)90940-X
10.1038/370199a0
10.1002/mrm.1910330219
10.1103/PhysRev.139.A1398
10.1016/0022-2364(86)90433-6
10.1103/PhysRevA.52.862

Dates

Type	When
Created	18 years, 5 months ago (March 11, 2007, 6:04 p.m.)
Deposited	1 year, 11 months ago (Sept. 27, 2023, 10:22 a.m.)
Indexed	3 months, 2 weeks ago (May 23, 2025, 2:42 p.m.)
Issued	29 years, 1 month ago (Aug. 1, 1996)
Published	29 years, 1 month ago (Aug. 1, 1996)
Published Online	19 years, 8 months ago (Dec. 12, 2005)
Published Print	29 years, 1 month ago (Aug. 1, 1996)

Funders 0

None

BibTeX

@article{Bachert_1996, title={Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized 3He}, volume={36}, ISSN={1522-2594}, url={http://dx.doi.org/10.1002/mrm.1910360204}, DOI={10.1002/mrm.1910360204}, number={2}, journal={Magnetic Resonance in Medicine}, publisher={Wiley}, author={Bachert, Peter and Schad, Lothar R. and Bock, Michael and Knopp, Michael V. and Ebert, Michael and Grobmann, Tino and Heil, Werner and Hofmann, Dirk and Surkau, Reinhard and Otten, Ernst W.}, year={1996}, month=aug, pages={192–196} }

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