DOI: 10.1002/mrm.10268. High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity

High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity

10.1002/mrm.10268

Crossref journal-article

Wiley

Magnetic Resonance in Medicine (311)

Abstract

AbstractMagnetic resonance (MR) diffusion tensor imaging (DTI) can resolve the white matter fiber orientation within a voxel provided that the fibers are strongly aligned. However, a given voxel may contain a distribution of fiber orientations due to, for example, intravoxel fiber crossing. The present study sought to test whether a geodesic, highb‐value diffusion gradient sampling scheme could resolve multiple fiber orientations within a single voxel. In regions of fiber crossing the diffusion signal exhibited multiple local maxima/minima as a function of diffusion gradient orientation, indicating the presence of multiple intravoxel fiber orientations. The multimodality of the observed diffusion signal precluded the standard tensor reconstruction, so instead the diffusion signal was modeled as arising from a discrete mixture of Gaussian diffusion processes in slow exchange, and the underlying mixture of tensors was solved for using a gradient descent scheme. The multitensor reconstruction resolved multiple intravoxel fiber populations corresponding to known fiber anatomy. Magn Reson Med 48:577–582, 2002. © 2002 Wiley‐Liss, Inc.

Bibliography

Tuch, D. S., Reese, T. G., Wiegell, M. R., Makris, N., Belliveau, J. W., & Wedeen, V. J. (2002). High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity. Magnetic Resonance in Medicine, 48(4), 577â582. Portico.

Authors 6

David S. Tuch (first)
Timothy G. Reese (additional)
Mette R. Wiegell (additional)
Nikos Makris (additional)
John W. Belliveau (additional)
Van J. Wedeen (additional)

References 27 Referenced 1,328

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TuchDS WeisskoffRM BelliveauJW WedeenVJ.High angular resolution diffusion imaging of the human brain. In: Proceedings of the 7th Annual Meeting of ISMRM Philadelphia 1999. p321.
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Dates

Type	When
Created	22 years, 10 months ago (Oct. 9, 2002, 12:29 a.m.)
Deposited	8 months, 3 weeks ago (Dec. 10, 2024, 5:11 a.m.)
Indexed	25 minutes ago (Sept. 3, 2025, 4:50 a.m.)
Issued	22 years, 11 months ago (Sept. 26, 2002)
Published	22 years, 11 months ago (Sept. 26, 2002)
Published Online	22 years, 11 months ago (Sept. 26, 2002)
Published Print	22 years, 11 months ago (Oct. 1, 2002)

Funders 0

None

BibTeX

@article{Tuch_2002, title={High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity}, volume={48}, ISSN={1522-2594}, url={http://dx.doi.org/10.1002/mrm.10268}, DOI={10.1002/mrm.10268}, number={4}, journal={Magnetic Resonance in Medicine}, publisher={Wiley}, author={Tuch, David S. and Reese, Timothy G. and Wiegell, Mette R. and Makris, Nikos and Belliveau, John W. and Wedeen, Van J.}, year={2002}, month=sep, pages={577–582} }

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