DOI: 10.1002/mrm.10183. Changes in axonal morphology in experimental autoimmune neuritis as studied by high b‐value q‐space 1H and 2H DQF diffusion magnetic resonance spectroscopy

Changes in axonal morphology in experimental autoimmune neuritis as studied by high b‐value q‐space 1H and 2H DQF diffusion magnetic resonance spectroscopy

10.1002/mrm.10183

Crossref journal-article

Wiley

Magnetic Resonance in Medicine (311)

Abstract

AbstractExperimental autoimmune neuritis (EAN) has been studied in rat sciatic nerves by a combination of high b‐value 1H and 2H double quantum filtered (DQF) diffusion MRS. The signal decays of water in the 1H and 2H DQF diffusion MRS were found to be not monoexponential and were analyzed using the q‐space approach. The q‐space analysis of the 1H diffusion data detected two diffusing components, one having broad and the other having narrow displacement profiles. These components were shown to be very sensitive to the progression of EAN disease. The q‐space parameters were found to be abnormal at day 9 postimmunization before the appearance of clinical signs. The assignment of the component with the narrow displacement profile to axonal water has been corroborated by the 2H DQF diffusion MRS results. The displacement and the relative population of this slow and restricted diffusing component followed the processes of demyelination, axonal loss, and remyelination that occur in EAN. The displacements extracted from the slow‐diffusing component with the narrow displacement correlated well with the average size of the axons as deduced from electron microscopy (EM). The component with the broad displacement showed significant changes which were attributed to the formation of endoneurial edema. This observation was also corroborated by the 2H DQF diffusion MRS experiments. It seems, therefore, that q‐space analysis of high b‐values diffusion MRS is a promising new approach for early detection and better characterization of the different pathologies associated with EAN. This study demonstrates the utility of high‐b‐value q‐space diffusion MRS for studying white matter‐associated disorders in general. Magn Reson Med 48:71–81, 2002. © 2002 Wiley‐Liss, Inc.

Bibliography

Assaf, Y., Kafri, M., Shinar, H., Chapman, J., Korczyn, A. D., Navon, G., & Cohen, Y. (2002). Changes in axonal morphology in experimental autoimmune neuritis as studied by high bâvalue qâspace 1H and 2H DQF diffusion magnetic resonance spectroscopy. Magnetic Resonance in Medicine, 48(1), 71â81. Portico.

Authors 7

Yaniv Assaf (first)
Michal Kafri (additional)
Hadassah Shinar (additional)
Joab Chapman (additional)
Amos D. Korczyn (additional)
Gil Navon (additional)
Yoram Cohen (additional)

References 31 Referenced 25

10.1016/S1357-4310(99)01639-1
{'key': 'e_1_2_6_3_2', 'first-page': '209', 'article-title': 'Morphologic study on experimental allergic neuritis mediated by T cell line specific for bovine P2 protein in Lewis rats', 'volume': '53', 'author': 'Izumo S', 'year': '1985', 'journal-title': 'Lab Invest'} / Lab Invest / Morphologic study on experimental allergic neuritis mediated by T cell line specific for bovine P2 protein in Lewis rats by Izumo S (1985)
{'key': 'e_1_2_6_4_2', 'first-page': '115', 'article-title': 'Demyelination and axonal degeneration in Lewis rat experimental allergic neuritis depend on the myelin dosage', 'volume': '59', 'author': 'Hahn AF', 'year': '1988', 'journal-title': 'Lab Invest'} / Lab Invest / Demyelination and axonal degeneration in Lewis rat experimental allergic neuritis depend on the myelin dosage by Hahn AF (1988)
10.1086/513794
10.1086/513787
{'key': 'e_1_2_6_7_2', 'first-page': '332', 'article-title': 'Early changes in experimental allergic neuritis', 'volume': '48', 'author': 'Powell HC', 'year': '1983', 'journal-title': 'Lab Invest'} / Lab Invest / Early changes in experimental allergic neuritis by Powell HC (1983)
10.1111/j.1750-3639.1999.tb00231.x
10.1016/0022-510X(88)90015-9
10.1136/jnnp.55.10.909
10.1002/mrm.1910360607
10.1006/jmre.1997.1313
10.1002/(SICI)1099-1492(199902)12:1<51::AID-NBM546>3.0.CO;2-E
10.1002/mrm.1910400310
10.1002/(SICI)1522-2594(200002)43:2<191::AID-MRM5>3.0.CO;2-B
10.1002/(SICI)1522-2594(199911)42:5<911::AID-MRM11>3.0.CO;2-J
10.1002/(SICI)1099-1492(199910)12:6<335::AID-NBM581>3.0.CO;2-A
10.1002/1522-2594(200011)44:5<713::AID-MRM9>3.0.CO;2-6
10.1038/351467a0
10.1002/mrm.1910140303
10.1006/jmra.1995.1060
10.1006/jmra.1995.1055
AssafY MaykA CohenY.q‐Space diffusion MRI of demyelination in stroke prone spontaneously hypertensive rats. In: Proc 8th Annual Meeting ISMRM Denver 2000. p470.
AssafY Ben‐BashatD PeledS ChapmanJ SegevY HendlerT KorczynAD GraifM CohenY.Evaluation of the physiological state of white matter by highbvalue q‐space analyzed diffusion weighted imaging: applications to multiple sclerosis. In: Proc 9th Annual Meeting of ISMRM Glasgow 2001. p150.
10.1002/mrm.10040
10.1006/jmre.1997.1250
10.1006/jmrb.1995.1058
10.1002/mrm.1910370210
10.1002/nbm.687
10.1006/jmrb.1996.0125
10.1002/(SICI)1522-2594(199909)42:3<461::AID-MRM8>3.0.CO;2-L
10.1002/1522-2594(200102)45:2<191::AID-MRM1025>3.0.CO;2-9

Dates

Type	When
Created	22 years, 11 months ago (Sept. 10, 2002, 10:05 p.m.)
Deposited	1 year, 10 months ago (Oct. 9, 2023, 8:44 p.m.)
Indexed	1 year, 3 months ago (May 17, 2024, 10:59 p.m.)
Issued	23 years, 2 months ago (June 27, 2002)
Published	23 years, 2 months ago (June 27, 2002)
Published Online	23 years, 2 months ago (June 27, 2002)
Published Print	23 years, 2 months ago (July 1, 2002)

Funders 0

None

BibTeX

@article{Assaf_2002, title={Changes in axonal morphology in experimental autoimmune neuritis as studied by high b‐value q‐space 1H and 2H DQF diffusion magnetic resonance spectroscopy}, volume={48}, ISSN={1522-2594}, url={http://dx.doi.org/10.1002/mrm.10183}, DOI={10.1002/mrm.10183}, number={1}, journal={Magnetic Resonance in Medicine}, publisher={Wiley}, author={Assaf, Yaniv and Kafri, Michal and Shinar, Hadassah and Chapman, Joab and Korczyn, Amos D. and Navon, Gil and Cohen, Yoram}, year={2002}, month=jun, pages={71–81} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        5,
        18
      ]
    ],
    "date-time": "2024-05-18T02:59:08Z",
    "timestamp": 1716001148535
  },
  "reference-count": 31,
  "publisher": "Wiley",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2002,
            6,
            27
          ]
        ],
        "date-time": "2002-06-27T00:00:00Z",
        "timestamp": 1025136000000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [
      "onlinelibrary.wiley.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2002,
        7
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>Experimental autoimmune neuritis (EAN) has been studied in rat sciatic nerves by a combination of high <jats:italic>b</jats:italic>\u2010value <jats:sup>1</jats:sup>H and <jats:sup>2</jats:sup>H double quantum filtered (DQF) diffusion MRS. The signal decays of water in the <jats:sup>1</jats:sup>H and <jats:sup>2</jats:sup>H DQF diffusion MRS were found to be not monoexponential and were analyzed using the q\u2010space approach. The q\u2010space analysis of the <jats:sup>1</jats:sup>H diffusion data detected two diffusing components, one having broad and the other having narrow displacement profiles. These components were shown to be very sensitive to the progression of EAN disease. The q\u2010space parameters were found to be abnormal at day 9 postimmunization before the appearance of clinical signs. The assignment of the component with the narrow displacement profile to axonal water has been corroborated by the <jats:sup>2</jats:sup>H DQF diffusion MRS results. The displacement and the relative population of this slow and restricted diffusing component followed the processes of demyelination, axonal loss, and remyelination that occur in EAN. The displacements extracted from the slow\u2010diffusing component with the narrow displacement correlated well with the average size of the axons as deduced from electron microscopy (EM). The component with the broad displacement showed significant changes which were attributed to the formation of endoneurial edema. This observation was also corroborated by the <jats:sup>2</jats:sup>H DQF diffusion MRS experiments. It seems, therefore, that q\u2010space analysis of high <jats:italic>b</jats:italic>\u2010values diffusion MRS is a promising new approach for early detection and better characterization of the different pathologies associated with EAN. This study demonstrates the utility of high\u2010<jats:italic>b</jats:italic>\u2010value q\u2010space diffusion MRS for studying white matter\u2010associated disorders in general. Magn Reson Med 48:71\u201381, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.</jats:p>",
  "DOI": "10.1002/mrm.10183",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        9,
        11
      ]
    ],
    "date-time": "2002-09-11T02:05:28Z",
    "timestamp": 1031709928000
  },
  "page": "71-81",
  "update-policy": "http://dx.doi.org/10.1002/crossmark_policy",
  "source": "Crossref",
  "is-referenced-by-count": 25,
  "title": "Changes in axonal morphology in experimental autoimmune neuritis as studied by high <i>b</i>\u2010value q\u2010space <sup>1</sup>H and <sup>2</sup>H DQF diffusion magnetic resonance spectroscopy",
  "prefix": "10.1002",
  "volume": "48",
  "author": [
    {
      "given": "Yaniv",
      "family": "Assaf",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Michal",
      "family": "Kafri",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Hadassah",
      "family": "Shinar",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Joab",
      "family": "Chapman",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Amos D.",
      "family": "Korczyn",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Gil",
      "family": "Navon",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yoram",
      "family": "Cohen",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2002,
        6,
        27
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_6_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1357-4310(99)01639-1"
    },
    {
      "key": "e_1_2_6_3_2",
      "first-page": "209",
      "article-title": "Morphologic study on experimental allergic neuritis mediated by T cell line specific for bovine P2 protein in Lewis rats",
      "volume": "53",
      "author": "Izumo S",
      "year": "1985",
      "journal-title": "Lab Invest"
    },
    {
      "key": "e_1_2_6_4_2",
      "first-page": "115",
      "article-title": "Demyelination and axonal degeneration in Lewis rat experimental allergic neuritis depend on the myelin dosage",
      "volume": "59",
      "author": "Hahn AF",
      "year": "1988",
      "journal-title": "Lab Invest"
    },
    {
      "key": "e_1_2_6_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1086/513794"
    },
    {
      "key": "e_1_2_6_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1086/513787"
    },
    {
      "key": "e_1_2_6_7_2",
      "first-page": "332",
      "article-title": "Early changes in experimental allergic neuritis",
      "volume": "48",
      "author": "Powell HC",
      "year": "1983",
      "journal-title": "Lab Invest"
    },
    {
      "key": "e_1_2_6_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1750-3639.1999.tb00231.x"
    },
    {
      "key": "e_1_2_6_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0022-510X(88)90015-9"
    },
    {
      "key": "e_1_2_6_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jnnp.55.10.909"
    },
    {
      "key": "e_1_2_6_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/mrm.1910360607"
    },
    {
      "key": "e_1_2_6_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmre.1997.1313"
    },
    {
      "key": "e_1_2_6_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1099-1492(199902)12:1<51::AID-NBM546>3.0.CO;2-E"
    },
    {
      "key": "e_1_2_6_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/mrm.1910400310"
    },
    {
      "key": "e_1_2_6_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1522-2594(200002)43:2<191::AID-MRM5>3.0.CO;2-B"
    },
    {
      "key": "e_1_2_6_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1522-2594(199911)42:5<911::AID-MRM11>3.0.CO;2-J"
    },
    {
      "key": "e_1_2_6_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1099-1492(199910)12:6<335::AID-NBM581>3.0.CO;2-A"
    },
    {
      "key": "e_1_2_6_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/1522-2594(200011)44:5<713::AID-MRM9>3.0.CO;2-6"
    },
    {
      "key": "e_1_2_6_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/351467a0"
    },
    {
      "key": "e_1_2_6_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/mrm.1910140303"
    },
    {
      "key": "e_1_2_6_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmra.1995.1060"
    },
    {
      "key": "e_1_2_6_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmra.1995.1055"
    },
    {
      "key": "e_1_2_6_23_2",
      "unstructured": "AssafY MaykA CohenY.q\u2010Space diffusion MRI of demyelination in stroke prone spontaneously hypertensive rats. In: Proc 8th Annual Meeting ISMRM Denver 2000. p470."
    },
    {
      "key": "e_1_2_6_24_2",
      "unstructured": "AssafY Ben\u2010BashatD PeledS ChapmanJ SegevY HendlerT KorczynAD GraifM CohenY.Evaluation of the physiological state of white matter by highbvalue q\u2010space analyzed diffusion weighted imaging: applications to multiple sclerosis. In: Proc 9th Annual Meeting of ISMRM Glasgow 2001. p150."
    },
    {
      "key": "e_1_2_6_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/mrm.10040"
    },
    {
      "key": "e_1_2_6_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmre.1997.1250"
    },
    {
      "key": "e_1_2_6_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmrb.1995.1058"
    },
    {
      "key": "e_1_2_6_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/mrm.1910370210"
    },
    {
      "key": "e_1_2_6_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/nbm.687"
    },
    {
      "key": "e_1_2_6_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmrb.1996.0125"
    },
    {
      "key": "e_1_2_6_31_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1522-2594(199909)42:3<461::AID-MRM8>3.0.CO;2-L"
    },
    {
      "key": "e_1_2_6_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/1522-2594(200102)45:2<191::AID-MRM1025>3.0.CO;2-9"
    }
  ],
  "container-title": "Magnetic Resonance in Medicine",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmrm.10183",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/mrm.10183",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        10
      ]
    ],
    "date-time": "2023-10-10T00:44:12Z",
    "timestamp": 1696898652000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/mrm.10183"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2002,
        6,
        27
      ]
    ]
  },
  "references-count": 31,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2002,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/mrm.10183"
  ],
  "URL": "http://dx.doi.org/10.1002/mrm.10183",
  "relation": {},
  "ISSN": [
    "0740-3194",
    "1522-2594"
  ],
  "subject": [],
  "container-title-short": "Magnetic Resonance in Med",
  "published": {
    "date-parts": [
      [
        2002,
        6,
        27
      ]
    ]
  },
  "assertion": [
    {
      "value": "2001-07-27",
      "order": 0,
      "name": "received",
      "label": "Received",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "2002-02-20",
      "order": 1,
      "name": "accepted",
      "label": "Accepted",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "2002-06-27",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}