DOI: 10.1002/mrc.1341. Amyloidosis of Alzheimer's Aβ peptides: solid‐state nuclear magnetic resonance, electron paramagnetic resonance, transmission electron microscopy, scanning transmission electron microscopy and atomic force microscopy studies

Amyloidosis of Alzheimer's Aβ peptides: solid‐state nuclear magnetic resonance, electron paramagnetic resonance, transmission electron microscopy, scanning transmission electron microscopy and atomic force microscopy studies

10.1002/mrc.1341

Crossref journal-article

Wiley

Magnetic Resonance in Chemistry (311)

Abstract

AbstractAggregation cascade for Alzheimer's amyloid‐β peptides, its relevance to neurotoxicity in the course of Alzheimer's disease and experimental methods useful for these studies are discussed. Details of the solid‐phase peptide synthesis and sample preparation procedures for Alzheimer's β‐amyloid fibrils are given. Recent progress in obtaining structural constraints on Aβ‐fibrils from solid‐state NMR and scanning transmission electron microscopy (STEM) data is discussed. Polymorphism of amyloid fibrils and oligomers of the ‘Arctic’ mutant of Aβ(1–40) was studied by 1H,13C solid‐state NMR, transmission electron microscopy (TEM) and atomic force microscopy (AFM), and a real‐time aggregation of different polymorphs of the peptide was observed with the aid of in situ AFM. Recent results on binding of Cu(II) ions and Al–citrate and Al–ATP complexes to amyloid fibrils, as studied by electron paramagnetic resonance (EPR) and solid‐state 27Al NMR techniques, are also presented. Copyright © 2004 John Wiley & Sons, Ltd.

Bibliography

Antzutkin, O. N. (2004). Amyloidosis of Alzheimerâs AÎ² peptides: solidâstate nuclear magnetic resonance, electron paramagnetic resonance, transmission electron microscopy, scanning transmission electron microscopy and atomic force microscopy studies. Magnetic Resonance in Chemistry, 42(2), 231â246. Portico.

Authors 1

Oleg N. Antzutkin (first)

References 138 Referenced 68

{'key': 'e_1_2_1_2_2', 'first-page': '146', 'volume': '64', 'author': 'Alzheimer A', 'year': '1907', 'journal-title': 'Z. Psychiatry'} / Z. Psychiatry by Alzheimer A (1907)
{'key': 'e_1_2_1_3_2', 'first-page': '89', 'volume-title': "How We Die, Reflections of Life's Final Chapter", 'author': 'Nuland SB', 'year': '1995'} / How We Die, Reflections of Life's Final Chapter by Nuland SB (1995)
http://www.alzheimerforeningen.nu.
10.1038/scientificamerican1191-68
10.1016/S0006-291X(84)80190-4
10.1016/0006-291X(84)91209-9
10.1002/j.1460-2075.1985.tb04000.x
10.1038/325733a0
10.1126/science.257.5075.1336.b
10.1016/0197-4580(89)90075-4
10.1002/ana.410300410
{'key': 'e_1_2_1_13_2', 'first-page': '57', 'article-title': "Deciphering Alzheimer's disease: molecular genetics and cell biology yield major clues", 'volume': '7', 'author': 'Selkoe DJ', 'year': '1995', 'journal-title': 'J. NIH Res.'} / J. NIH Res. / Deciphering Alzheimer's disease: molecular genetics and cell biology yield major clues by Selkoe DJ (1995)
SelkoeDJ Invited Lecture at NIH 15 November2000.
10.1002/j.1460-2075.1988.tb02952.x
10.1073/pnas.86.16.6338
10.1016/0092-8674(89)90177-3
10.1038/341144a0
10.1126/science.1691865
10.1073/pnas.87.15.6003
10.1126/science.1439760
10.1038/359322a0
10.1146/annurev.bi.61.070192.004503
10.1042/bj3110001
10.1146/annurev.biochem.66.1.385
{'key': 'e_1_2_1_26_2', 'first-page': '51', 'volume': '7', 'author': 'Roses AD', 'year': '1995', 'journal-title': 'J. NIH Res.'} / J. NIH Res. by Roses AD (1995)
10.1016/0006-8993(91)91553-D
10.1523/JNEUROSCI.13-04-01676.1993
10.1046/j.1471-4159.1995.64010253.x
10.1073/pnas.91.25.12243
10.1006/neur.1995.0003
10.1126/science.2218531
10.1152/ajpcell.1989.257.1.C147
10.1016/S0021-9258(18)54721-9 / J. Biol. Chem. by Joslin G (1991)
10.1073/pnas.90.22.10573
10.1073/pnas.90.2.567
10.1016/S0006-3495(94)80717-9
10.1006/bbrc.1994.2047
10.1016/S0006-3495(97)78048-2
10.1074/jbc.273.22.13379
10.1073/pnas.91.8.3270
10.1006/bbrc.1994.1508
10.1016/0361-9230(95)02034-X
10.1016/S0006-291X(86)80241-8
10.1016/0006-291X(87)91008-4
10.1073/pnas.84.19.6953
10.1021/bi00463a003
10.1002/jnr.490280404
10.1016/S0006-3495(91)82154-3
10.1006/jmbi.1994.1704
10.1016/0022-2836(91)90881-6
10.1111/j.1432-1033.1991.tb16256.x
10.1016/0022-2836(92)90835-8
10.1126/science.1853202
10.1016/0022-2836(92)90106-T
10.1016/S0021-9258(18)48529-8
10.1006/jsbi.1997.3859
10.1016/S0006-3495(98)77812-9
10.1073/pnas.83.2.503
10.1073/pnas.90.22.10836
10.1073/pnas.95.11.6448
10.1038/ng0692-218
10.1126/science.2111584
{'key': 'e_1_2_1_64_2', 'first-page': 'S28', 'volume': '2', 'author': 'Tagliavini F', 'year': '1999', 'journal-title': 'Alz. Rep.'} / Alz. Rep. by Tagliavini F (1999)
10.1038/nn0901-887
10.1002/ana.1009
10.1006/jmbi.2001.4970
10.1097/00005072-198107000-00009
10.1126/science.3544219
LeapmanRD personal communication.
10.1021/bi00139a028
10.1021/bi00015a033
10.1111/j.1432-1033.1994.tb19935.x
10.1021/bi00191a006
10.1021/ja9738687
10.1021/bi972979f
10.1039/b103352m
10.1016/S0959-440X(98)80157-7
{'key': 'e_1_2_1_79_2', 'first-page': '280', 'volume-title': 'Solid State Nuclear Magnetic Resonance Spectroscopy, Principles and Application', 'author': 'Antzutkin ON', 'year': '2002'} / Solid State Nuclear Magnetic Resonance Spectroscopy, Principles and Application by Antzutkin ON (2002)
10.1021/bi027378p
10.1073/pnas.262663499
10.1021/bi0204185
10.1063/1.477876
10.1073/pnas.230315097
10.1016/S0301-0104(01)00250-6
10.1016/S0006-3495(02)75244-2
10.1021/ja960178e
10.1021/bi0011330
10.1016/S0006-3495(03)70057-5
10.1006/jmre.2000.2281
10.1021/bi982997c
10.1096/fj.01-0377com
{'key': 'e_1_2_1_93_2', 'first-page': '160', 'volume': '121', 'author': 'Edwardson JA', 'year': '1986', 'journal-title': 'Ciba Found. Symp.'} / Ciba Found. Symp. by Edwardson JA (1986)
10.1016/B978-044450811-9/50047-1
10.1074/jbc.M205659200
10.1038/nsb838
10.1074/jbc.M100175200
10.1074/jbc.M205455200
10.1006/jmre.1999.1776
10.1021/jp020906m
10.1073/pnas.95.23.13407
10.1016/S0926-2040(98)00086-1
10.1021/ja000645z
10.1021/bi991527v
10.1021/bi00003a003
10.1074/jbc.271.15.8545
10.1006/jsbi.2000.4259
10.1006/jmbi.2000.3711
10.1006/jmbi.2000.3559
10.1021/ja9607650
10.1007/BF00227471
{'key': 'e_1_2_1_112_2', 'author': 'Hellberg M', 'journal-title': 'J. Mol. Biol.'} / J. Mol. Biol. by Hellberg M
10.1073/pnas.79.13.4050
10.1146/annurev.bb.15.060186.002035
10.1016/0304-3991(92)90022-C
10.1111/j.1768-322X.1994.tb00929.x
10.1016/S0022-510X(98)00092-6
10.1111/j.1471-4159.1993.tb03639.x
10.1074/jbc.273.21.12817
10.1016/0014-5793(93)80137-J
10.1016/0014-5793(95)00388-P
10.1016/0278-6915(84)90369-7
10.1016/0020-711X(91)90289-Y
10.1097/00001756-199710200-00043
AntzutkinON TóthI TyckoR HowesA DupreeR. To be submitted toFEBS Lett.
10.1111/j.1365-2818.1984.tb00489.x
10.1111/j.1365-2818.1992.tb01482.x
10.1016/0304-3991(91)90108-I
10.1021/bi0259857
10.1021/bi000637v
10.1006/jmbi.2000.3650
10.1038/nsb1195-990
10.1006/jsbi.2000.4287
10.1038/416535a
10.1073/pnas.222681699
10.1126/science.1079469
10.1016/0969-2126(93)90013-7
http://www.inorg.kth.se/MEDUSA.
10.1016/0022-2364(90)90130-2

Dates

Type	When
Created	21 years, 7 months ago (Jan. 19, 2004, 3:01 a.m.)
Deposited	1 year, 11 months ago (Sept. 12, 2023, 2:35 a.m.)
Indexed	1 year, 1 month ago (June 30, 2024, 1:48 a.m.)
Issued	21 years, 7 months ago (Jan. 14, 2004)
Published	21 years, 7 months ago (Jan. 14, 2004)
Published Online	21 years, 7 months ago (Jan. 14, 2004)
Published Print	21 years, 6 months ago (Feb. 1, 2004)

Funders 4

Swedish Foundation of International Cooperation in Research and Higher Education (STINT).
Swedish Research Council.
Swedish Alzheimer's Fund.
Foundation to the Memory of J. C. and Seth M. Kempe.

BibTeX

@article{Antzutkin_2004, title={Amyloidosis of Alzheimer’s Aβ peptides: solid‐state nuclear magnetic resonance, electron paramagnetic resonance, transmission electron microscopy, scanning transmission electron microscopy and atomic force microscopy studies}, volume={42}, ISSN={1097-458X}, url={http://dx.doi.org/10.1002/mrc.1341}, DOI={10.1002/mrc.1341}, number={2}, journal={Magnetic Resonance in Chemistry}, publisher={Wiley}, author={Antzutkin, Oleg N.}, year={2004}, month=jan, pages={231–246} }

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