DOI: 10.1002/mds.23643. Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease

Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease

10.1002/mds.23643

Crossref journal-article

Wiley

Movement Disorders (311)

Bibliography

Du, G., Lewis, M. M., Styner, M., Shaffer, M. L., Sen, S., Yang, Q. X., & Huang, X. (2011). Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinsonâs Disease. Movement Disorders, 26(9), 1627â1632. Portico.

Authors 7

Guangwei Du (first)
Mechelle M. Lewis (additional)
Martin Styner (additional)
Michele L. Shaffer (additional)
Suman Sen (additional)
Qing X. Yang (additional)
Xuemei Huang (additional)

References 24 Referenced 148

10.1212/01.wnl.0000286384.31050.b5 / Neurology / Midbrain iron content in early Parkinson disease: a potential biomarker of disease status by Martin (2008)
10.1212/WNL.45.6.1138 / Neurology / Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease by Gorell (1995)
10.1136/jnnp.2007.121525 / J Neurol Neurosurg Psychiatry / Case control study of diffusion tensor imaging in Parkinson's disease by Chan (2007)
10.1212/01.wnl.0000340982.01727.6e / Neurology / High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease by Vaillancourt (2009)
10.1097/00005072-196801000-00001 / J Neuropathol Exp Neurol / Studies on Parkinson's disease including x-ray fluorescent spectroscopy of formalin fixed brain tissue by Earle (1968)
10.1111/j.1471-4159.1989.tb07264.x / J Neurochem / Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease by Dexter (1989)
10.1007/BF01244786 / J Neural Transm / Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain by Sofic (1988)
10.1002/mrm.1910320309 / Magn Reson Med / Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla by Ordidge (1994)
10.1148/radiology.210.3.r99fe41759 / Radiology / MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content by Gelman (1999)
10.1016/j.mri.2004.10.001 / Magn Reson Imaging / Imaging iron stores in the brain using magnetic resonance imaging by Haacke (2005)
10.1002/mds.870110305 / Mov Disord / Basal ganglia iron content in Parkinson's disease measured with magnetic resonance by Ye (1996)
10.1016/j.neuroimage.2010.03.005 / Neuroimage / Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease by Baudrexel (2010)
10.1093/brain/awq212 / Brain / Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature by Peran (2010)
10.1006/jmrb.1996.0086 / J Magn Reson B / Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI by Basser (1996)
10.1016/j.neuron.2006.08.012 / Neuron / Principles of diffusion tensor imaging and its applications to basic neuroscience research by Mori (2006)
10.1016/j.nbd.2007.02.010 / Neurobiol Dis / Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease by Boska (2007)
10.1136/jnnp.2003.021873 / J Neurol Neurosurg Psychiatry / Early pathological changes in the parkinsonian brain demonstrated by diffusion tensor MRI by Yoshikawa (2004)
10.1002/ana.410320721 / Ann Neurol / Criteria for diagnosing Parkinson's disease by Calne (1992)
10.1016/S1361-8415(01)00036-6 / Med Image Anal / A global optimisation method for robust affine registration of brain images by Jenkinson (2001)
10.1016/j.neuroimage.2004.07.051 / Neuroimage / Advances in functional and structural MR image analysis and implementation as FSL by Smith (2004)
{'key': '10.1002/mds.23643-BIB21|cit21', 'first-page': '1747', 'article-title': 'The substantia nigra in Parkinson disease: proton density-weighted spin-echo and fast short inversion time inversion-recovery MR findings', 'volume': '23', 'author': 'Oikawa', 'year': '2002', 'journal-title': 'AJNR Am J Neuroradiol'} / AJNR Am J Neuroradiol / The substantia nigra in Parkinson disease: proton density-weighted spin-echo and fast short inversion time inversion-recovery MR findings by Oikawa (2002)
10.1016/j.neuroimage.2006.01.015 / Neuroimage / User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability by Yushkevich (2006)
{'key': '10.1002/mds.23643-BIB23|cit23', 'article-title': 'Effects of aging on the ventral and dorsal substantia nigra using diffusion tensor imaging', 'author': 'Vaillancourt', 'year': '2010', 'journal-title': 'Neurobiol Aging'} / Neurobiol Aging / Effects of aging on the ventral and dorsal substantia nigra using diffusion tensor imaging by Vaillancourt (2010)
10.1093/brain/114.5.2283 / Brain / Ageing and Parkinson's disease: substantia nigra regional selectivity by Fearnley (1991)

Dates

Type	When
Created	14 years, 2 months ago (May 26, 2011, 12:27 p.m.)
Deposited	4 years, 1 month ago (July 5, 2021, 7:22 a.m.)
Indexed	3 months, 2 weeks ago (May 6, 2025, 6:35 p.m.)
Issued	14 years, 2 months ago (May 26, 2011)
Published	14 years, 2 months ago (May 26, 2011)
Published Online	14 years, 2 months ago (May 26, 2011)
Published Print	14 years ago (Aug. 1, 2011)

Funders 3

Unknown funding agency
Awards1
1. NS060722
HMC GCRC
Awards1
1. NIH M01RR10732
GCRC Construction Grant
Awards1
1. C06RR016499

BibTeX

@article{Du_2011, title={Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson’s Disease: Iron AND FA Changes IN SN OF PD Patients}, volume={26}, ISSN={0885-3185}, url={http://dx.doi.org/10.1002/mds.23643}, DOI={10.1002/mds.23643}, number={9}, journal={Movement Disorders}, publisher={Wiley}, author={Du, Guangwei and Lewis, Mechelle M. and Styner, Martin and Shaffer, Michele L. and Sen, Suman and Yang, Qing X. and Huang, Xuemei}, year={2011}, month=may, pages={1627–1632} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        6
      ]
    ],
    "date-time": "2025-05-06T22:35:41Z",
    "timestamp": 1746570941748
  },
  "reference-count": 24,
  "publisher": "Wiley",
  "issue": "9",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2011,
            5,
            26
          ]
        ],
        "date-time": "2011-05-26T00:00:00Z",
        "timestamp": 1306368000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://doi.wiley.com/10.1002/tdm_license_1.1"
    },
    {
      "start": {
        "date-parts": [
          [
            2011,
            5,
            26
          ]
        ],
        "date-time": "2011-05-26T00:00:00Z",
        "timestamp": 1306368000000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "funder": [
    {
      "name": "Unknown funding agency",
      "award": [
        "NS060722"
      ]
    },
    {
      "name": "HMC GCRC",
      "award": [
        "NIH M01RR10732"
      ]
    },
    {
      "name": "GCRC Construction Grant",
      "award": [
        "C06RR016499"
      ]
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2011,
        8,
        1
      ]
    ]
  },
  "DOI": "10.1002/mds.23643",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2011,
        5,
        26
      ]
    ],
    "date-time": "2011-05-26T16:27:10Z",
    "timestamp": 1306427230000
  },
  "page": "1627-1632",
  "source": "Crossref",
  "is-referenced-by-count": 148,
  "title": "Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease",
  "prefix": "10.1002",
  "volume": "26",
  "author": [
    {
      "given": "Guangwei",
      "family": "Du",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Mechelle M.",
      "family": "Lewis",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Martin",
      "family": "Styner",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Michele L.",
      "family": "Shaffer",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Suman",
      "family": "Sen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Qing X.",
      "family": "Yang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Xuemei",
      "family": "Huang",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2011,
        5,
        26
      ]
    ]
  },
  "reference": [
    {
      "key": "10.1002/mds.23643-BIB1|cit1",
      "doi-asserted-by": "crossref",
      "first-page": "1411",
      "DOI": "10.1212/01.wnl.0000286384.31050.b5",
      "article-title": "Midbrain iron content in early Parkinson disease: a potential biomarker of disease status",
      "volume": "70",
      "author": "Martin",
      "year": "2008",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1002/mds.23643-BIB2|cit2",
      "doi-asserted-by": "crossref",
      "first-page": "1138",
      "DOI": "10.1212/WNL.45.6.1138",
      "article-title": "Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease",
      "volume": "45",
      "author": "Gorell",
      "year": "1995",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1002/mds.23643-BIB3|cit3",
      "doi-asserted-by": "crossref",
      "first-page": "1383",
      "DOI": "10.1136/jnnp.2007.121525",
      "article-title": "Case control study of diffusion tensor imaging in Parkinson's disease",
      "volume": "78",
      "author": "Chan",
      "year": "2007",
      "journal-title": "J Neurol Neurosurg Psychiatry"
    },
    {
      "key": "10.1002/mds.23643-BIB4|cit4",
      "doi-asserted-by": "crossref",
      "first-page": "1378",
      "DOI": "10.1212/01.wnl.0000340982.01727.6e",
      "article-title": "High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease",
      "volume": "72",
      "author": "Vaillancourt",
      "year": "2009",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1002/mds.23643-BIB5|cit5",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1097/00005072-196801000-00001",
      "article-title": "Studies on Parkinson's disease including x-ray fluorescent spectroscopy of formalin fixed brain tissue",
      "volume": "27",
      "author": "Earle",
      "year": "1968",
      "journal-title": "J Neuropathol Exp Neurol"
    },
    {
      "key": "10.1002/mds.23643-BIB6|cit6",
      "doi-asserted-by": "crossref",
      "first-page": "1830",
      "DOI": "10.1111/j.1471-4159.1989.tb07264.x",
      "article-title": "Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease",
      "volume": "52",
      "author": "Dexter",
      "year": "1989",
      "journal-title": "J Neurochem"
    },
    {
      "key": "10.1002/mds.23643-BIB7|cit7",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1007/BF01244786",
      "article-title": "Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain",
      "volume": "74",
      "author": "Sofic",
      "year": "1988",
      "journal-title": "J Neural Transm"
    },
    {
      "key": "10.1002/mds.23643-BIB8|cit8",
      "doi-asserted-by": "crossref",
      "first-page": "335",
      "DOI": "10.1002/mrm.1910320309",
      "article-title": "Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla",
      "volume": "32",
      "author": "Ordidge",
      "year": "1994",
      "journal-title": "Magn Reson Med"
    },
    {
      "key": "10.1002/mds.23643-BIB9|cit9",
      "doi-asserted-by": "crossref",
      "first-page": "759",
      "DOI": "10.1148/radiology.210.3.r99fe41759",
      "article-title": "MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content",
      "volume": "210",
      "author": "Gelman",
      "year": "1999",
      "journal-title": "Radiology"
    },
    {
      "key": "10.1002/mds.23643-BIB10|cit10",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/j.mri.2004.10.001",
      "article-title": "Imaging iron stores in the brain using magnetic resonance imaging",
      "volume": "23",
      "author": "Haacke",
      "year": "2005",
      "journal-title": "Magn Reson Imaging"
    },
    {
      "key": "10.1002/mds.23643-BIB11|cit11",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1002/mds.870110305",
      "article-title": "Basal ganglia iron content in Parkinson's disease measured with magnetic resonance",
      "volume": "11",
      "author": "Ye",
      "year": "1996",
      "journal-title": "Mov Disord"
    },
    {
      "key": "10.1002/mds.23643-BIB12|cit12",
      "doi-asserted-by": "crossref",
      "first-page": "512",
      "DOI": "10.1016/j.neuroimage.2010.03.005",
      "article-title": "Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease",
      "volume": "51",
      "author": "Baudrexel",
      "year": "2010",
      "journal-title": "Neuroimage"
    },
    {
      "key": "10.1002/mds.23643-BIB13|cit13",
      "doi-asserted-by": "crossref",
      "first-page": "3423",
      "DOI": "10.1093/brain/awq212",
      "article-title": "Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature",
      "volume": "133",
      "author": "Peran",
      "year": "2010",
      "journal-title": "Brain"
    },
    {
      "key": "10.1002/mds.23643-BIB14|cit14",
      "doi-asserted-by": "crossref",
      "first-page": "209",
      "DOI": "10.1006/jmrb.1996.0086",
      "article-title": "Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI",
      "volume": "111",
      "author": "Basser",
      "year": "1996",
      "journal-title": "J Magn Reson B"
    },
    {
      "key": "10.1002/mds.23643-BIB15|cit15",
      "doi-asserted-by": "crossref",
      "first-page": "527",
      "DOI": "10.1016/j.neuron.2006.08.012",
      "article-title": "Principles of diffusion tensor imaging and its applications to basic neuroscience research",
      "volume": "51",
      "author": "Mori",
      "year": "2006",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1002/mds.23643-BIB16|cit16",
      "doi-asserted-by": "crossref",
      "first-page": "590",
      "DOI": "10.1016/j.nbd.2007.02.010",
      "article-title": "Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease",
      "volume": "26",
      "author": "Boska",
      "year": "2007",
      "journal-title": "Neurobiol Dis"
    },
    {
      "key": "10.1002/mds.23643-BIB17|cit17",
      "doi-asserted-by": "crossref",
      "first-page": "481",
      "DOI": "10.1136/jnnp.2003.021873",
      "article-title": "Early pathological changes in the parkinsonian brain demonstrated by diffusion tensor MRI",
      "volume": "75",
      "author": "Yoshikawa",
      "year": "2004",
      "journal-title": "J Neurol Neurosurg Psychiatry"
    },
    {
      "issue": "Suppl",
      "key": "10.1002/mds.23643-BIB18|cit18",
      "doi-asserted-by": "crossref",
      "first-page": "S125",
      "DOI": "10.1002/ana.410320721",
      "article-title": "Criteria for diagnosing Parkinson's disease",
      "volume": "32",
      "author": "Calne",
      "year": "1992",
      "journal-title": "Ann Neurol"
    },
    {
      "key": "10.1002/mds.23643-BIB19|cit19",
      "doi-asserted-by": "crossref",
      "first-page": "143",
      "DOI": "10.1016/S1361-8415(01)00036-6",
      "article-title": "A global optimisation method for robust affine registration of brain images",
      "volume": "5",
      "author": "Jenkinson",
      "year": "2001",
      "journal-title": "Med Image Anal"
    },
    {
      "issue": "Suppl 1",
      "key": "10.1002/mds.23643-BIB20|cit20",
      "doi-asserted-by": "crossref",
      "first-page": "S208",
      "DOI": "10.1016/j.neuroimage.2004.07.051",
      "article-title": "Advances in functional and structural MR image analysis and implementation as FSL",
      "volume": "23",
      "author": "Smith",
      "year": "2004",
      "journal-title": "Neuroimage"
    },
    {
      "key": "10.1002/mds.23643-BIB21|cit21",
      "first-page": "1747",
      "article-title": "The substantia nigra in Parkinson disease: proton density-weighted spin-echo and fast short inversion time inversion-recovery MR findings",
      "volume": "23",
      "author": "Oikawa",
      "year": "2002",
      "journal-title": "AJNR Am J Neuroradiol"
    },
    {
      "key": "10.1002/mds.23643-BIB22|cit22",
      "doi-asserted-by": "crossref",
      "first-page": "1116",
      "DOI": "10.1016/j.neuroimage.2006.01.015",
      "article-title": "User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability",
      "volume": "31",
      "author": "Yushkevich",
      "year": "2006",
      "journal-title": "Neuroimage"
    },
    {
      "key": "10.1002/mds.23643-BIB23|cit23",
      "article-title": "Effects of aging on the ventral and dorsal substantia nigra using diffusion tensor imaging",
      "author": "Vaillancourt",
      "year": "2010",
      "journal-title": "Neurobiol Aging"
    },
    {
      "key": "10.1002/mds.23643-BIB24|cit24",
      "doi-asserted-by": "crossref",
      "first-page": "2283",
      "DOI": "10.1093/brain/114.5.2283",
      "article-title": "Ageing and Parkinson's disease: substantia nigra regional selectivity",
      "volume": "114",
      "author": "Fearnley",
      "year": "1991",
      "journal-title": "Brain"
    }
  ],
  "container-title": "Movement Disorders",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmds.23643",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmds.23643",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://onlinelibrary.wiley.com/wol1/doi/10.1002/mds.23643/fullpdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        7,
        5
      ]
    ],
    "date-time": "2021-07-05T11:22:23Z",
    "timestamp": 1625484143000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/mds.23643"
    }
  },
  "subtitle": [
    "Iron AND FA Changes IN SN OF PD Patients"
  ],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2011,
        5,
        26
      ]
    ]
  },
  "references-count": 24,
  "journal-issue": {
    "issue": "9",
    "published-print": {
      "date-parts": [
        [
          2011,
          8,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1002/mds.23643",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.13357383.14726795",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0885-3185"
  ],
  "subject": [],
  "container-title-short": "Mov. Disord.",
  "published": {
    "date-parts": [
      [
        2011,
        5,
        26
      ]
    ]
  }
}