DOI: 10.1002/mds.23384. Cysteinyl‐glycine reduction as marker for levodopa‐induced oxidative stress in Parkinson's disease patients

Cysteinyl‐glycine reduction as marker for levodopa‐induced oxidative stress in Parkinson's disease patients

10.1002/mds.23384

Crossref journal-article

Wiley

Movement Disorders (311)

Abstract

AbstractOxidative stress is influenced by the thiol homeostasis, which determines the redox milieu. One of its components is Cysteinyl‐glycine (Cys‐Gly) generation, as its metabolic precursor is the free radicals scavenging glutathione. Levodopa is under suspicion to promote oxidative stress via the turnover of its metabolite dopamine in abundant mitochondria. Objective was to investigate the impact of levodopa on Cys‐Gly plasma metabolism. Fifteen patients with Parkinson's disease orally took one 200‐mg levodopa/50‐mg carbidopa (CD) containing tablet. Levodopa, its derivative 3‐O‐methyldopa (3‐OMD), and free Cys‐Gly were measured at baseline, 60 and 120 min following levodopa/CD administration. Cys‐gly concentrations decreased, levodopa and 3‐OMD levels increased. Inverse relationships appeared between computed differences of Cys‐gly and 3‐OMD bioavailability. We conclude that Cys‐Gly decline is related to levodopa metabolism to 3‐OMD. Cys‐Gly decay may result from the alternative transformation of glutathione to its oxidized form glutathione dissulfide as consequence of free radical scavenging. © 2011 Movement Disorder Society

Bibliography

MÃ¼ller, T., & Muhlack, S. (2011). Cysteinylâglycine reduction as marker for levodopaâinduced oxidative stress in Parkinsonâs disease patients. Movement Disorders, 26(3), 543â546. Portico.

Authors 2

Thomas Müller (first)
Siegfried Muhlack (additional)

References 8 Referenced 30

10.1042/BST0331375 / Biochem Soc Trans / Thiol redox control via thioredoxin and glutaredoxin systems by Holmgren A (2005)
10.1016/j.neures.2007.10.002
10.1016/j.parkreldis.2007.06.015
10.1136/jnnp.55.3.181
10.1523/JNEUROSCI.3602-07.2008
10.1007/s11064-007-9442-6
10.1159/000007984
10.1002/mds.22482

Dates

Type	When
Created	14 years, 5 months ago (April 1, 2011, 5:50 p.m.)
Deposited	1 year, 10 months ago (Oct. 9, 2023, 12:21 p.m.)
Indexed	1 month, 1 week ago (July 26, 2025, 4:41 a.m.)
Issued	14 years, 6 months ago (Feb. 15, 2011)
Published	14 years, 6 months ago (Feb. 15, 2011)
Published Online	14 years, 5 months ago (April 1, 2011)
Published Print	14 years, 6 months ago (Feb. 15, 2011)

Funders 0

None

BibTeX

@article{M_ller_2011, title={Cysteinyl‐glycine reduction as marker for levodopa‐induced oxidative stress in Parkinson’s disease patients}, volume={26}, ISSN={1531-8257}, url={http://dx.doi.org/10.1002/mds.23384}, DOI={10.1002/mds.23384}, number={3}, journal={Movement Disorders}, publisher={Wiley}, author={Müller, Thomas and Muhlack, Siegfried}, year={2011}, month=feb, pages={543–546} }

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