DOI: 10.1002/mds.22184. Neuronal gene expression correlates of Parkinson's disease with dementia

Neuronal gene expression correlates of Parkinson's disease with dementia

10.1002/mds.22184

Crossref journal-article

Wiley

Movement Disorders (311)

Abstract

AbstractDementia is a common disabling complication in patients with Parkinson's disease (PD). The underlying molecular causes of Parkinson's disease with dementia (PDD) are poorly understood. To identify candidate genes and molecular pathways involved in PDD, we have performed whole genome expression profiling of susceptible cortical neuronal populations. Results show significant differences in expression of 162 genes (P < 0.01) between PD patients who are cognitively normal (PD‐CogNL) and controls. In contrast, there were 556 genes (P < 0.01) significantly altered in PDD compared to either healthy controls or to PD‐CogNL cases. These results are consistent with increased cortical pathology in PDD relative to PD‐CogNL and identify underlying molecular changes associated with the increased pathology of PDD. Lastly, we have identified expression differences in 69 genes in PD cortical neurons that occur before the onset of dementia and that are exacerbated upon the development of dementia, suggesting that they may be relevant presymptomatic contributors to the onset of dementia in PD. These results provide new insights into the cortical molecular changes associated with PDD and provide a highly useful reference database for researchers interested in PDD. © 2008 Movement Disorder Society

Bibliography

Stamper, C., Siegel, A., Liang, W. S., Pearson, J. V., Stephan, D. A., Shill, H., Connor, D., Caviness, J. N., Sabbagh, M., Beach, T. G., Adler, C. H., & Dunckley, T. (2008). Neuronal gene expression correlates of Parkinsonâs disease with dementia. Movement Disorders, 23(11), 1588â1595. Portico.

Authors 12

Chelsea Stamper (first)
Andrew Siegel (additional)
Winnie S. Liang (additional)
John V. Pearson (additional)
Dietrich A. Stephan (additional)
Holly Shill (additional)
Don Connor (additional)
John N. Caviness (additional)
Marwan Sabbagh (additional)
Thomas G. Beach (additional)
Charles H. Adler (additional)
Travis Dunckley (additional)

References 26 Referenced 46

10.1016/S1474-4422(03)00351-X
10.1093/ageing/afi190
{'key': 'e_1_2_6_4_2', 'first-page': '311', 'volume-title': 'Handbook of neuropsychology', 'author': 'Pillon B', 'year': '2001'} / Handbook of neuropsychology by Pillon B (2001)
10.1136/jnnp.69.5.584
10.1073/pnas.0509567103
10.1002/mds.10565
10.1007/s00401-003-0705-2
10.1007/s004019900168
10.1212/01.WNL.0000165987.89198.65
10.1212/01.wnl.0000180964.60708.c2
10.1038/35006074
10.1523/JNEUROSCI.22-07-02780.2002
10.1073/pnas.0536383100
10.1523/JNEUROSCI.20-16-06048.2000
10.1126/science.1090278
10.1002/ana.410430612
10.1007/s10048-006-0077-6
10.1007/s10048-005-0020-2
10.1001/archneur.62.6.917
10.1007/s00702-004-0212-1
10.1016/j.nbd.2007.02.009
{'key': 'e_1_2_6_23_2', 'first-page': '615', 'article-title': "Rapid brain autopsy. The Joseph and Kathleen Bryan Alzheimer's disease research center experience", 'volume': '121', 'author': 'Hulette CM', 'year': '1997', 'journal-title': 'Arch Pathol Lab Med'} / Arch Pathol Lab Med / Rapid brain autopsy. The Joseph and Kathleen Bryan Alzheimer's disease research center experience by Hulette CM (1997)
{'key': 'e_1_2_6_24_2', 'volume-title': "LightCycler Operator's Manual. Version 3.5. Roche Diagnostics GmbH", 'author': 'Roche Molecular Biochemicals ME', 'year': '2000'} / LightCycler Operator's Manual. Version 3.5. Roche Diagnostics GmbH by Roche Molecular Biochemicals ME (2000)
10.1111/j.1471-4159.2006.04204.x
10.1007/s10048-005-0001-5
10.1016/j.nbd.2007.03.007

Dates

Type	When
Created	17 years, 1 month ago (July 22, 2008, 4:27 p.m.)
Deposited	1 year, 10 months ago (Oct. 17, 2023, 9:23 p.m.)
Indexed	1 month ago (July 31, 2025, 11:48 p.m.)
Issued	17 years, 1 month ago (July 22, 2008)
Published	17 years, 1 month ago (July 22, 2008)
Published Online	17 years, 1 month ago (July 22, 2008)
Published Print	17 years ago (Aug. 15, 2008)

Funders 0

None

BibTeX

@article{Stamper_2008, title={Neuronal gene expression correlates of Parkinson’s disease with dementia}, volume={23}, ISSN={1531-8257}, url={http://dx.doi.org/10.1002/mds.22184}, DOI={10.1002/mds.22184}, number={11}, journal={Movement Disorders}, publisher={Wiley}, author={Stamper, Chelsea and Siegel, Andrew and Liang, Winnie S. and Pearson, John V. and Stephan, Dietrich A. and Shill, Holly and Connor, Don and Caviness, John N. and Sabbagh, Marwan and Beach, Thomas G. and Adler, Charles H. and Dunckley, Travis}, year={2008}, month=jul, pages={1588–1595} }

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