DOI: 10.1002/lary.24618. Laryngeal chondrosarcoma: A population‐based analysis

Laryngeal chondrosarcoma: A population‐based analysis

10.1002/lary.24618

Crossref journal-article

Wiley

The Laryngoscope (311)

Abstract

Objectives/HypothesisLaryngeal chondrosarcoma (LC) is a rare entity, reportedly comprising less than 1% of all laryngeal tumors. Consequently, the incidence and survival of patients with this slow‐growing tumor has been difficult to study. Our objective was to evaluate incidence, organized by patient demographics, as well as long‐term survival trends of this malignancy using a population‐based database.Study DesignRetrospective analysis of the United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry.MethodsThe SEER database was searched for patients diagnosed with LC between 1973 and 2010. Data analyzed included patient demographics, incidence, treatment modality, and survival.ResultsOne‐hundred and forty‐three cases were identified, representing 0.2% of all laryngeal tumors. Median age at diagnosis was 61.7 years. Men and women constituted 76.2% and 23.8% of patients, respectively. Tumors were locally invasive with 37.7% T4 disease and infrequent regional and distant metastases. The 1‐year, 5‐year, and 10‐year disease‐specific survival for LC was 96.5%, 88.6%, and 84.8%, respectively, compared to 88.3%, 68.2%, and 59.3%, respectively for patients with all other laryngeal tumors (P values < 0.01). Relative survival was 94.9% at 1 year, 88.5% at 5 years, and 88.4% at 10 years.ConclusionsThis analysis represents the largest LC study sample to date, allowing for evaluation of incidence and long‐term survival. LC occurs infrequently, is locally invasive, but only rarely metastasizes. Prognosis for LC is significantly better than for other laryngeal malignancies.Level of Evidence2b. Laryngoscope, 124:1877–1881, 2014

Bibliography

Dubal, P. M., Svider, P. F., Kanumuri, V. V., Patel, A. A., Baredes, S., & Eloy, J. A. (2014). Laryngeal chondrosarcoma: A populationâbased analysis. The Laryngoscope, 124(8), 1877â1881. Portico.

Authors 6

Pariket M. Dubal (first)
Peter F. Svider (additional)
Vivek V. Kanumuri (additional)
Amit A. Patel (additional)
Soly Baredes (additional)
Jean Anderson Eloy (additional)

References 33 Referenced 73

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10.1177/095952871600700109
{'key': 'e_1_2_6_4_1', 'first-page': '681', 'article-title': 'Chondrosarcoma of the larynx', 'volume': '14', 'author': 'Buda I', 'year': '2012', 'journal-title': 'IMAJ'} / IMAJ / Chondrosarcoma of the larynx by Buda I (2012)
10.1097/00000478-200207000-00002
10.1002/(SICI)1097-0142(19980101)82:1<108::AID-CNCR13>3.0.CO;2-6
{'key': 'e_1_2_6_7_1', 'first-page': '2925', 'article-title': 'Chondrosarcoma of the larynx and review of the literature', 'volume': '27', 'author': 'Sauter A', 'year': '2007', 'journal-title': 'Anticancer Res'} / Anticancer Res / Chondrosarcoma of the larynx and review of the literature by Sauter A (2007)
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10.1097/00020840-200404000-00008
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{'key': 'e_1_2_6_23_1', 'article-title': 'Radiation therapy is associated with fewer recurrences in mesenchymal chondrosarcoma', 'author': 'Kawaguchi S', 'year': '2013', 'journal-title': 'Clin Orthop Relat Res'} / Clin Orthop Relat Res / Radiation therapy is associated with fewer recurrences in mesenchymal chondrosarcoma by Kawaguchi S (2013)
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Dates

Type	When
Created	11 years, 6 months ago (Jan. 29, 2014, 5:23 a.m.)
Deposited	2 years ago (Aug. 20, 2023, 11:31 a.m.)
Indexed	37 minutes ago (Aug. 28, 2025, 4:11 a.m.)
Issued	11 years, 5 months ago (March 11, 2014)
Published	11 years, 5 months ago (March 11, 2014)
Published Online	11 years, 5 months ago (March 11, 2014)
Published Print	11 years ago (Aug. 1, 2014)

Funders 0

None

BibTeX

@article{Dubal_2014, title={Laryngeal chondrosarcoma: A population‐based analysis}, volume={124}, ISSN={1531-4995}, url={http://dx.doi.org/10.1002/lary.24618}, DOI={10.1002/lary.24618}, number={8}, journal={The Laryngoscope}, publisher={Wiley}, author={Dubal, Pariket M. and Svider, Peter F. and Kanumuri, Vivek V. and Patel, Amit A. and Baredes, Soly and Eloy, Jean Anderson}, year={2014}, month=mar, pages={1877–1881} }

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