DOI: 10.1002/jnr.490370405. Isoforms of ferritin have a specific cellular distribution in the brain

Isoforms of ferritin have a specific cellular distribution in the brain

10.1002/jnr.490370405

Crossref journal-article

Wiley

Journal of Neuroscience Research (311)

Abstract

AbstractFerritin is the major iron storage protein and accounts for the majority of the iron in the brain. Thus, ferritin is a key component in protecting the brain from iron induced oxidative damage. The high lipid content, high rate of oxidative metabolism, and high iron content combine to make the brain the organ most susceptible to oxidative stress. The role of oxidative damage and disruption of brain iron homeostasis is considered clinically important to normal aging and a potential pathogenic component of a number of neurologic disorders including Alzheimer's disease and Parkinson's disease. Little is known, however, of the mechanism by which the brain maintains iron homeostasis at either the whole organ or cellular level. In this study we report the cellular distribution of the two isoforms of ferritin in the brain of adult subhuman primates. A subset of neurons immunolabel specifically for the H‐chain ferritin protein, whereas cells resembling microglia are immunolabeled only after exposure to the L‐chain ferritin antibody. Only one cell type immunostains for both H‐and L‐chain ferritin; these cells are morphologically similar and have the same distribution pattern as oligodendrocytes. Neither ferritin isoform is usually detected in astrocytes. These data indicate considerable differences in iron sequestration and use between neurons and glia and among neuronal and glial subtypes. This information will be essential in determining the role of each of these cells in maintaining general brain iron homeostasis and the relative abilities of these cells to withstand oxidative stress. © 1994 Wiley‐Liss, Inc.

Bibliography

Connor, J. R., Boeshore, K. L., Benkovic, S. A., & Menzies, S. L. (1994). Isoforms of ferritin have a specific cellular distribution in the brain. Journal of Neuroscience Research, 37(4), 461â465. Portico.

Authors 4

J. R. Connor (first)
K. L. Boeshore (additional)
S. A. Benkovic (additional)
S. L. Menzies (additional)

References 24 Referenced 155

10.1177/29.6.7252134
{'key': 'e_1_2_1_3_1', 'first-page': '127', 'volume-title': 'Biotechnology of Plasma Proteins', 'author': 'Arosio P', 'year': '1991'} / Biotechnology of Plasma Proteins by Arosio P (1991)
10.1016/S0021-9258(19)37165-0 / J Biol Chem / Ferritin: A cytoprotective antioxidant strategem of endothelium by Balla G (1992)
10.1002/cne.903380108
10.1042/bj2750813
10.1002/jnr.490140303
10.1002/ana.410320710
10.1002/jnr.490270421
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10.1111/j.1471-4159.1990.tb08814.x
10.1016/S0079-6603(08)60612-1
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10.1111/j.1471-4159.1989.tb09150.x

Dates

Type	When
Created	20 years, 7 months ago (Dec. 31, 2004, 8:57 p.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, 2:51 a.m.)
Indexed	2 months ago (June 26, 2025, 12:46 p.m.)
Issued	31 years, 5 months ago (March 1, 1994)
Published	31 years, 5 months ago (March 1, 1994)
Published Online	20 years, 10 months ago (Oct. 11, 2004)
Published Print	31 years, 5 months ago (March 1, 1994)

Funders 0

None

BibTeX

@article{Connor_1994, title={Isoforms of ferritin have a specific cellular distribution in the brain}, volume={37}, ISSN={1097-4547}, url={http://dx.doi.org/10.1002/jnr.490370405}, DOI={10.1002/jnr.490370405}, number={4}, journal={Journal of Neuroscience Research}, publisher={Wiley}, author={Connor, J. R. and Boeshore, K. L. and Benkovic, S. A. and Menzies, S. L.}, year={1994}, month=mar, pages={461–465} }

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