DOI: 10.1002/jnr.490340610. T‐Cadherin 2: Molecular characterization, function in cell adhesion, and coexpression with T‐cadherin and N‐cadherin

T‐Cadherin 2: Molecular characterization, function in cell adhesion, and coexpression with T‐cadherin and N‐cadherin

10.1002/jnr.490340610

Crossref journal-article

Wiley

Journal of Neuroscience Research (311)

Abstract

AbstractCadherins are integral membrane glycoproteins that mediate calcium‐dependent, homophilic cell‐cell adhesion and are implicated in controlling tissue morphogenesis. T‐cadherin is anchored to the membrane through a glycosyl phosphatidylinositol (Ranscht B, Dours‐Zimmermann MT: Neuron 7:391–402, 1991) and expressed in a restricted pattern in developing embryos (Ranscht B, Bronner‐Fraser M: Development 111:15–22, 1991). We report here the molecular and functional characterization of the T‐cadherin isoform, T‐cadherin 2 (Tcad‐2) and the expression of the corresponding mRNA. Tcad‐2 cDNA differs in its 3′nucleotide sequence from T‐cadherin cDNA and encodes a protein in which the carboxy terminal Leu of T‐cadherin is substituted by Lys and extended by the amino acids SerPheProTyrVal. By RNase protection, mRNAs encoding the T‐cadherin isoforms are coexpressed in heart, muscle, liver, skin, somites, and in neural tissue. Many tissues contain both T‐cadherin and Tcad‐2 mRNAs in conjunction with N‐cadherin transcripts, and T‐cadherins and N‐cadherin proteins are coexpressed on the surface of individual neurons in vitro. Expression in Chinese hamster ovary cells (CHO) revealed that Tcad‐2 is a glycosyl phosphati‐dylinositol‐anchored membrane protein that functions in calcium‐dependent, homophilic cell adhesion. The identification of a functional T‐cadherin isoform and the coexpression of T‐cadherins and N‐cadherin by individual cells suggest that specific adhesive interactions of embryonic cells may involve a complex interplay between multiple cadherins. © 1993 Wiley‐Liss, Inc.

Bibliography

SacristÃ¡n, M. P., Vestal, D. J., DoursâZimmermann, M. T., & Ranscht, B. (1993). TâCadherin 2: Molecular characterization, function in cell adhesion, and coexpression with Tâcadherin and Nâcadherin. Journal of Neuroscience Research, 34(6), 664â680. Portico.

Authors 4

M. P. Sacristán (first)
D. J. Vestal (additional)
M. T. Dours‐Zimmermann (additional)
B. Ranscht (additional)

References 67 Referenced 30

10.1083/jcb.98.3.934
10.1083/jcb.110.4.1253
10.1073/pnas.84.8.2555
10.1093/nar/3.9.2303
10.1089/dna.1983.2.329
10.1021/bi00591a005
10.1073/pnas.81.7.1991
10.1016/0092-8674(80)90238-X
10.1083/jcb.113.2.381
10.1016/0014-5793(90)80198-R
10.1016/0896-6273(90)90108-R
10.1016/0012-1606(90)90178-L
10.1083/jcb.104.5.1361
10.1242/dev.103.2.325 / Development / Spatial and temporal distribution of the adherens‐junction‐associated adhesion molecule A‐CAM during avian embryogenesis by Duband J‐L (1988)
10.1146/annurev.bi.60.070191.001103
10.1073/pnas.84.23.8502
10.1242/dev.110.1.97
10.1073/pnas.84.9.2808
10.1002/jmor.1050880104
10.1038/320447a0
10.1073/pnas.82.9.2789
10.1016/0012-1606(87)90119-9
10.1083/jcb.106.3.873
10.1073/pnas.88.20.9156
10.1016/0092-8674(92)90472-O
10.1016/0896-6273(91)90075-B
10.1242/dev.113.3.959
10.1073/pnas.87.9.3589
10.1016/0896-6273(88)90204-8
10.1002/bies.950110403
{'key': 'e_1_2_1_32_1', 'first-page': '1', 'article-title': 'Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules', 'volume': '53', 'author': 'Koch PJ', 'year': '1990', 'journal-title': 'Eur J Cell Biol'} / Eur J Cell Biol / Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules by Koch PJ (1990)
10.1093/nar/11.23.8287
10.1002/j.1460-2075.1990.tb07456.x
10.1016/0304-4157(89)90014-2
10.1111/j.1432-0436.1988.tb00593.x
10.1038/334062a0
10.1126/science.1962194
10.1093/nar/12.18.7035
10.1126/science.2762814
10.1083/jcb.115.6.1595
10.1002/j.1460-2075.1988.tb03249.x
10.1091/mbc.1.1.37 / Cell Reg / Transmembrane control of cadherin‐mediates cell adhesion: A 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E‐cadherin by Nagafuchi A (1989)
10.1038/329341a0
10.1016/0092-8674(91)90392-C
10.1083/jcb.113.4.893
10.1002/j.1460-2075.1987.tb02698.x
10.1016/0092-8674(88)90114-6
10.1002/j.1460-2075.1989.tb03563.x
10.1073/pnas.87.11.4246
10.1016/1044-5765(91)90046-Q
10.1242/dev.111.1.15
{'key': 'e_1_2_1_53_1', 'first-page': '959', 'article-title': 'Selective expression of a novel cadherin in the pathways of developing motor‐ and commissural axons', 'volume': '15', 'author': 'Ranscht B', 'year': '1989', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / Selective expression of a novel cadherin in the pathways of developing motor‐ and commissural axons by Ranscht B (1989)
10.1016/0896-6273(91)90291-7
10.1083/jcb.99.5.1803
10.1002/j.1460-2075.1987.tb02697.x
10.1016/0167-5699(91)90110-F
10.1083/jcb.92.1.1
{'key': 'e_1_2_1_59_1', 'volume-title': 'Molecular Cloning. A Laboratory Manual', 'author': 'Sambrook J', 'year': '1989'} / Molecular Cloning. A Laboratory Manual by Sambrook J (1989)
{'key': 'e_1_2_1_60_1', 'first-page': '1364', 'article-title': 'DNA sequencing with chain terminating inhibitors', 'volume': '83', 'author': 'Sanger F', 'year': '1977', 'journal-title': 'Proc Natl Acad Sci USA'} / Proc Natl Acad Sci USA / DNA sequencing with chain terminating inhibitors by Sanger F (1977)
10.1091/mbc.2.4.261
10.1242/dev.102.4.639
10.1146/annurev.bi.59.070190.001321
10.1126/science.2006419
{'key': 'e_1_2_1_65_1', 'first-page': '158a', 'article-title': 'Characterization of T‐cadherin and its coexpression with N‐cadherin in developing chick myoblasts', 'volume': '11', 'author': 'Vestal DJ', 'year': '1990', 'journal-title': 'J Cell Biol'} / J Cell Biol / Characterization of T‐cadherin and its coexpression with N‐cadherin in developing chick myoblasts by Vestal DJ (1990)
10.1083/jcb.119.2.451
10.1002/j.1460-2075.1984.tb02123.x
10.1111/j.1471-4159.1990.tb04563.x

Dates

Type	When
Created	20 years, 2 months ago (May 28, 2005, 2:47 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 7:28 a.m.)
Indexed	1 year, 3 months ago (May 27, 2024, 7:54 a.m.)
Issued	32 years, 4 months ago (April 15, 1993)
Published	32 years, 4 months ago (April 15, 1993)
Published Online	20 years, 10 months ago (Oct. 11, 2004)
Published Print	32 years, 4 months ago (April 15, 1993)

Funders 0

None

BibTeX

@article{Sacrist_n_1993, title={T‐Cadherin 2: Molecular characterization, function in cell adhesion, and coexpression with T‐cadherin and N‐cadherin}, volume={34}, ISSN={1097-4547}, url={http://dx.doi.org/10.1002/jnr.490340610}, DOI={10.1002/jnr.490340610}, number={6}, journal={Journal of Neuroscience Research}, publisher={Wiley}, author={Sacristán, M. P. and Vestal, D. J. and Dours‐Zimmermann, M. T. and Ranscht, B.}, year={1993}, month=apr, pages={664–680} }

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