DOI: 10.1002/jnr.490270319. Type 1 astrocytes and oligodendrocyte‐type 2 astrocyte glial progenitors migrate toward distinct molecules

Type 1 astrocytes and oligodendrocyte‐type 2 astrocyte glial progenitors migrate toward distinct molecules

10.1002/jnr.490270319

Crossref journal-article

Wiley

Journal of Neuroscience Research (311)

Abstract

AbstractDuring central nervous system (CNS) development, glial precursors proliferate in subventricular zones and then migrate throughout the CNS to adopt their final destinations and differentiate into various types of mature glial cells. Although several growth factors promoting the proliferation and/or differentiation of glial precursors have been identified, very little is known about the nature of signals that guide glial cell migration in the CNS. Therefore, we have investigated whether polypeptide growth factors and/or extracellular matrix molecules may mediate the migration of two major glial cell types, type 1 astrocytes and oligodendrocyte‐type 2 astrocyte (O‐2A) progenitor cells. We show that, in a microchemotaxis chamber assay, type 1 astrocytes move toward laminin and complement‐derived C5a. Astrocyte migration toward laminin is inhibited by a laminin‐specific pentapeptide, YIGSR‐NH2. In contrast, O‐2A progenitors migrate toward platelet‐derived growth factor (PDGF), which also functions as a mitogen for these cells. Using a new method to simultaneously assay migration and DNA synthesis, we also demonstrate that O‐2A progenitors can migrate toward PDGF even when DNA replication is inhibited with an antimitotic agent. Thus, migration of different types of glial cells can be induced in vitro by specific signaling molecules, which are present in the developing brain and may stimulate migration of glial cells prior to CNS myelination.

Bibliography

Armstrong, R. C., Harvath, L., & DuboisâDalcq, M. E. (1990). Type 1 astrocytes and oligodendrocyteâtype 2 astrocyte glial progenitors migrate toward distinct molecules. Journal of Neuroscience Research, 27(3), 400â407. Portico.

Authors 3

R. C. Armstrong (first)
L. Harvath (additional)
M. E. Dubois‐Dalcq (additional)

References 45 Referenced 236

ArmstrongR FriedrichVL HolmesKV Dubois‐DalcqME(1990): In Vitro Analysis of the Oligodendrocyte Lineage in Mice during Demyelination and Remyelination.J Cell Biol.In press. (10.1083/jcb.111.3.1183)
10.1083/jcb.110.4.1427
10.1159/000112252
10.1002/jnr.490210209
{'issue': '3', 'key': 'e_1_2_1_6_1', 'first-page': '287', 'article-title': 'Modulation by TGFβ, of the Mitogenic Activity of FGF on Rat Oligodendrocytes in Culture', 'volume': '308', 'author': 'Besnard F', 'year': '1989', 'journal-title': 'C R Acad Sci Paris'} / C R Acad Sci Paris / Modulation by TGFβ, of the Mitogenic Activity of FGF on Rat Oligodendrocytes in Culture by Besnard F (1989)
10.1016/0736-5748(89)90061-0
10.1016/0006-8993(85)90802-9
10.1073/pnas.76.10.4913
10.1016/0006-8993(88)91123-7
10.1016/S0022-1759(80)80014-7 / J Immunol Methods / A 48 Well Micro Chemotaxis Assembly for Rapid and Accurate Measurement of Leukocyte Migration by Falk W (1980)
10.1523/JNEUROSCI.06-08-02163.1986
10.1002/jnr.490200107
10.1021/bi00396a004
10.1126/science.7123245
10.1083/jcb.109.6.3411
10.1242/dev.105.3.595 / Development / PDGF Receptors on Cells of the Oligodendrocyte‐Type‐2 Astrocyte (O‐2A)Cell Lineage by Hart IK (1989)
10.1016/0022-1759(80)90179-9
10.1016/0166-2236(90)90044-B
10.1159/000112359
LiesiP(1985): Do Neurons in the Vertebrate CNS Migrate on Laminin?EMBO J 4:1163–1170. (10.1002/j.1460-2075.1985.tb03755.x)
10.1523/JNEUROSCI.08-11-03992.1988 / J Neurosci / Embryonic Divergence of Oligodendrocyte and Astrocyte Lineages in Developing Rat Cerebrum by LeVine SM (1988)
10.1083/jcb.97.3.772
10.1083/jcb.85.3.890
10.1002/jnr.490210212
10.1002/j.1460-2075.1984.tb02122.x
10.1038/333560a0
10.1002/cne.901490106
10.1128/MCB.6.11.4060
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10.1038/280688a0
10.1126/science.2648568
10.1016/0006-8993(79)90851-5
10.1007/978-1-4613-2717-2_2
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YaoJ HarvathL GilbertDL ColtonCA(1990): Chemotaxis by the CNS Macrophage. The Microglia.J Neurosci Res.In press. (10.1002/jnr.490270106)

Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 12:42 a.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 5:30 a.m.)
Indexed	2 months ago (July 7, 2025, 2:28 a.m.)
Issued	34 years, 10 months ago (Nov. 1, 1990)
Published	34 years, 10 months ago (Nov. 1, 1990)
Published Online	20 years, 10 months ago (Oct. 11, 2004)
Published Print	34 years, 10 months ago (Nov. 1, 1990)

Funders 0

None

BibTeX

@article{Armstrong_1990, title={Type 1 astrocytes and oligodendrocyte‐type 2 astrocyte glial progenitors migrate toward distinct molecules}, volume={27}, ISSN={1097-4547}, url={http://dx.doi.org/10.1002/jnr.490270319}, DOI={10.1002/jnr.490270319}, number={3}, journal={Journal of Neuroscience Research}, publisher={Wiley}, author={Armstrong, R. C. and Harvath, L. and Dubois‐Dalcq, M. E.}, year={1990}, month=nov, pages={400–407} }

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