DOI: 10.1002/jnr.1084. Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus

Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus

10.1002/jnr.1084

Crossref journal-article

Wiley

Journal of Neuroscience Research (311)

Abstract

AbstractThe dentate gyrus is selectively reduced in size in the insulin‐like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of dentate gyrus size. At postnatal day 10 (P10), granule cell numbers were not significantly different in IGF1 null and littermate wildtype (WT) dentate gyri. The subgranular zone cell population, however, was relatively increased, and the granule cell layer population relatively decreased in the IGF1 null dentate gyrus. By P50, total dentate cell numbers were decreased by 20% (P = 0.01) in the IGF1 null mouse, although IGF1 null subgranular zone progenitor cells remained relatively increased compared with WT (38%, P < 0.05). IGF1 null dentate cell proliferation, assessed by thymidine analogue incorporation, was actually increased at P10 (33%, P < 0.05) and P50 (167%, P = 0.001). Dentate granule cell death, assessed by the appearance of pycnotic cells and DNA fragmentation, was also significantly increased in the IGF1 null dentate (61%, P < 0.05 and 101%, P = 0.03). These data suggest that endogenous IGF1 serves an important role in dentate granule cell survival during the course of postnatal brain development. In addition, this work suggests the potential of a compensatory mechanism promoting increased dentate cell proliferation in the face of impaired cell survival during postnatal neurogenesis. J. Neurosci. Res. 64:341–347, 2001. Published 2001 Wiley‐Liss, Inc.

Bibliography

Cheng, C. M., Cohen, M., Tseng, V., & Bondy, C. A. (2001). Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus. Journal of Neuroscience Research, 64(4), 341â347. Portico.

Authors 4

Clara M. Cheng (first)
Matt Cohen (additional)
Victor Tseng (additional)
Carolyn A. Bondy (additional)

References 34 Referenced 62

10.1523/JNEUROSCI.20-08-02896.2000
10.1016/0169-328X(91)90054-2
10.1016/S0012-1606(05)80021-1
10.1016/0896-6273(95)90216-3
10.1523/JNEUROSCI.19-06-01940.1999
10.1523/JNEUROSCI.11-11-03442.1991
10.1016/1044-7431(92)90027-Y
10.1111/j.1749-6632.1993.tb26244.x
10.1073/pnas.170008497
10.1523/JNEUROSCI.18-15-05673.1998 / J Neurosci / Biochemical and morphometric analyses show that myelination in the insulin‐like growth factor 1 null brain is proportionate to its neuronal composition by Cheng CM (1998)
10.1002/(SICI)1097-4695(19980905)36:3<379::AID-NEU6>3.0.CO;2-T
10.1073/pnas.85.11.4066
10.1073/pnas.94.9.4772
{'key': 'e_1_2_5_15_1', 'first-page': '326', 'article-title': 'Rediscovering an old friend, IGF‐I: potential use in the treatment of neurodegenerative diseases', 'volume': '20', 'author': 'Dore S', 'year': '1997', 'journal-title': 'Trends Neurosci'} / Trends Neurosci / Rediscovering an old friend, IGF‐I: potential use in the treatment of neurodegenerative diseases by Dore S (1997)
10.1111/j.1749-6632.1999.tb08015.x
10.1073/pnas.88.6.2199
10.1046/j.1471-4159.2002.00831.x
10.1152/ajpregu.2000.279.2.R548
10.1002/(SICI)1097-4695(199808)36:2<249::AID-NEU11>3.0.CO;2-9
10.1196/annals.1316.075
10.1074/jbc.274.14.9828
10.1136/adc.72.4.362
10.1002/jnr.490360607
10.1523/JNEUROSCI.20-02-00722.2000
10.1111/j.1460-9568.1996.tb01607.x
10.1038/376037a0
10.1523/JNEUROSCI.20-22-08435.2000
10.1101/gad.7.12b.2609
10.1210/endo.135.5.7525251
{'key': 'e_1_2_5_31_1', 'first-page': '613', 'article-title': 'Insulin‐like growth factor‐1 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke‐prone spontaneously hypertensive rats', 'volume': '76', 'author': 'Tagami M', 'year': '1997', 'journal-title': 'Lab Invest'} / Lab Invest / Insulin‐like growth factor‐1 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke‐prone spontaneously hypertensive rats by Tagami M (1997)
10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6
10.1038/6368
10.1056/NEJM199610313351805
10.1016/0896-6273(95)90217-1

Dates

Type	When
Created	23 years ago (Aug. 25, 2002, 4:13 p.m.)
Deposited	1 year, 9 months ago (Nov. 19, 2023, 12:39 p.m.)
Indexed	1 week ago (Aug. 30, 2025, 12:30 p.m.)
Issued	24 years, 4 months ago (April 30, 2001)
Published	24 years, 4 months ago (April 30, 2001)
Published Online	24 years, 4 months ago (April 30, 2001)
Published Print	24 years, 3 months ago (May 15, 2001)

Funders 0

None

BibTeX

@article{Cheng_2001, title={Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus}, volume={64}, ISSN={1097-4547}, url={http://dx.doi.org/10.1002/jnr.1084}, DOI={10.1002/jnr.1084}, number={4}, journal={Journal of Neuroscience Research}, publisher={Wiley}, author={Cheng, Clara M. and Cohen, Matt and Tseng, Victor and Bondy, Carolyn A.}, year={2001}, month=apr, pages={341–347} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        30
      ]
    ],
    "date-time": "2025-08-30T16:30:58Z",
    "timestamp": 1756571458553
  },
  "reference-count": 34,
  "publisher": "Wiley",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            4,
            30
          ]
        ],
        "date-time": "2001-04-30T00:00:00Z",
        "timestamp": 988588800000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        5,
        15
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>The dentate gyrus is selectively reduced in size in the insulin\u2010like growth factor 1 (<jats:italic>IGF1</jats:italic>) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of dentate gyrus size. At postnatal day 10 (P10), granule cell numbers were not significantly different in <jats:italic>IGF1</jats:italic> null and littermate wildtype (WT) dentate gyri. The subgranular zone cell population, however, was relatively increased, and the granule cell layer population relatively decreased in the <jats:italic>IGF1</jats:italic> null dentate gyrus. By P50, total dentate cell numbers were decreased by 20% (<jats:italic>P</jats:italic> = 0.01) in the <jats:italic>IGF1</jats:italic> null mouse, although <jats:italic>IGF1</jats:italic> null subgranular zone progenitor cells remained relatively increased compared with WT (38%, <jats:italic>P</jats:italic> &lt; 0.05). <jats:italic>IGF1</jats:italic> null dentate cell proliferation, assessed by thymidine analogue incorporation, was actually increased at P10 (33%, <jats:italic>P</jats:italic> &lt; 0.05) and P50 (167%, <jats:italic>P</jats:italic> = 0.001). Dentate granule cell death, assessed by the appearance of pycnotic cells and DNA fragmentation, was also significantly increased in the <jats:italic>IGF1</jats:italic> null dentate (61%, <jats:italic>P</jats:italic> &lt; 0.05 and 101%, <jats:italic>P</jats:italic> = 0.03). These data suggest that endogenous IGF1 serves an important role in dentate granule cell survival during the course of postnatal brain development. In addition, this work suggests the potential of a compensatory mechanism promoting increased dentate cell proliferation in the face of impaired cell survival during postnatal neurogenesis. J. Neurosci. Res. 64:341\u2013347, 2001. Published 2001 Wiley\u2010Liss, Inc.</jats:p>",
  "DOI": "10.1002/jnr.1084",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        8,
        25
      ]
    ],
    "date-time": "2002-08-25T20:13:04Z",
    "timestamp": 1030306384000
  },
  "page": "341-347",
  "source": "Crossref",
  "is-referenced-by-count": 62,
  "title": "Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus",
  "prefix": "10.1002",
  "volume": "64",
  "author": [
    {
      "given": "Clara M.",
      "family": "Cheng",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Matt",
      "family": "Cohen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Victor",
      "family": "Tseng",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Carolyn A.",
      "family": "Bondy",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2001,
        4,
        30
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_5_2_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.20-08-02896.2000"
    },
    {
      "key": "e_1_2_5_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0169-328X(91)90054-2"
    },
    {
      "key": "e_1_2_5_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0012-1606(05)80021-1"
    },
    {
      "key": "e_1_2_5_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0896-6273(95)90216-3"
    },
    {
      "key": "e_1_2_5_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.19-06-01940.1999"
    },
    {
      "key": "e_1_2_5_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.11-11-03442.1991"
    },
    {
      "key": "e_1_2_5_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/1044-7431(92)90027-Y"
    },
    {
      "key": "e_1_2_5_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.1993.tb26244.x"
    },
    {
      "key": "e_1_2_5_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.170008497"
    },
    {
      "key": "e_1_2_5_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "5673",
      "DOI": "10.1523/JNEUROSCI.18-15-05673.1998",
      "article-title": "Biochemical and morphometric analyses show that myelination in the insulin\u2010like growth factor 1 null brain is proportionate to its neuronal composition",
      "volume": "18",
      "author": "Cheng CM",
      "year": "1998",
      "journal-title": "J Neurosci"
    },
    {
      "key": "e_1_2_5_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1097-4695(19980905)36:3<379::AID-NEU6>3.0.CO;2-T"
    },
    {
      "key": "e_1_2_5_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.85.11.4066"
    },
    {
      "key": "e_1_2_5_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.9.4772"
    },
    {
      "key": "e_1_2_5_15_1",
      "first-page": "326",
      "article-title": "Rediscovering an old friend, IGF\u2010I: potential use in the treatment of neurodegenerative diseases",
      "volume": "20",
      "author": "Dore S",
      "year": "1997",
      "journal-title": "Trends Neurosci"
    },
    {
      "key": "e_1_2_5_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.1999.tb08015.x"
    },
    {
      "key": "e_1_2_5_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.88.6.2199"
    },
    {
      "key": "e_1_2_5_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1046/j.1471-4159.2002.00831.x"
    },
    {
      "key": "e_1_2_5_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpregu.2000.279.2.R548"
    },
    {
      "key": "e_1_2_5_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1097-4695(199808)36:2<249::AID-NEU11>3.0.CO;2-9"
    },
    {
      "key": "e_1_2_5_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1196/annals.1316.075"
    },
    {
      "key": "e_1_2_5_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.14.9828"
    },
    {
      "key": "e_1_2_5_23_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/adc.72.4.362"
    },
    {
      "key": "e_1_2_5_24_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jnr.490360607"
    },
    {
      "key": "e_1_2_5_25_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.20-02-00722.2000"
    },
    {
      "key": "e_1_2_5_26_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1460-9568.1996.tb01607.x"
    },
    {
      "key": "e_1_2_5_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/376037a0"
    },
    {
      "key": "e_1_2_5_28_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.20-22-08435.2000"
    },
    {
      "key": "e_1_2_5_29_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.7.12b.2609"
    },
    {
      "key": "e_1_2_5_30_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/endo.135.5.7525251"
    },
    {
      "key": "e_1_2_5_31_1",
      "first-page": "613",
      "article-title": "Insulin\u2010like growth factor\u20101 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke\u2010prone spontaneously hypertensive rats",
      "volume": "76",
      "author": "Tagami M",
      "year": "1997",
      "journal-title": "Lab Invest"
    },
    {
      "key": "e_1_2_5_32_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6"
    },
    {
      "key": "e_1_2_5_33_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/6368"
    },
    {
      "key": "e_1_2_5_34_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1056/NEJM199610313351805"
    },
    {
      "key": "e_1_2_5_35_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0896-6273(95)90217-1"
    }
  ],
  "container-title": "Journal of Neuroscience Research",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjnr.1084",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/jnr.1084",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        11,
        19
      ]
    ],
    "date-time": "2023-11-19T17:39:02Z",
    "timestamp": 1700415542000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/jnr.1084"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        4,
        30
      ]
    ]
  },
  "references-count": 34,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2001,
          5,
          15
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/jnr.1084"
  ],
  "URL": "http://dx.doi.org/10.1002/jnr.1084",
  "relation": {},
  "ISSN": [
    "0360-4012",
    "1097-4547"
  ],
  "subject": [],
  "container-title-short": "J of Neuroscience Research",
  "published": {
    "date-parts": [
      [
        2001,
        4,
        30
      ]
    ]
  }
}