DOI: 10.1002/jnr.10811. Estrogen and cognition: Applying preclinical findings to clinical perspectives

Estrogen and cognition: Applying preclinical findings to clinical perspectives

10.1002/jnr.10811

Crossref journal-article

Wiley

Journal of Neuroscience Research (311)

Abstract

AbstractThe effects of hormone replacement therapy on brain aging and cognition are an important public health issue, which, despite much research and debate, has not yet been resolved. In this Mini‐Review, we describe how much of the clinical literature takes on new meaning when interpreted in light of recent preclinical data. We predict, based on these data, that hormone replacement therapy will in fact provide substantial benefit with respect to age‐related cognitive decline, provided that therapy is administered in an appropriate regimen and is initiated within a window of time following the loss of ovarian function. The application of these data to recent clinical findings is discussed. © 2003 Wiley‐Liss, Inc.

Bibliography

Gibbs, R. B., & Gabor, R. (2003). Estrogen and cognition: Applying preclinical findings to clinical perspectives. Journal of Neuroscience Research, 74(5), 637â643. Portico.

Authors 2

Robert B. Gibbs (first)
Rachel Gabor (additional)

References 37 Referenced 132

10.1016/S0959-4388(99)80024-5
10.1016/S0306-4530(98)00068-7
10.2105/AJPH.88.9.1337
10.1523/JNEUROSCI.21-17-06949.2001
10.1016/S0031-9384(98)00272-8
10.1016/B978-012532104-4/50024-X
10.1146/annurev.psych.48.1.649
10.1097/00006250-200202000-00012
10.1016/S0006-8993(02)04053-2
10.1006/exnr.1998.6789
10.1006/hbeh.1999.1541
10.1016/S0306-4522(00)00433-4
10.1016/S0197-4580(00)00103-2
{'key': 'e_1_2_6_15_1', 'first-page': '117', 'volume-title': 'Neuroplasticity, development, and steroid hormone action', 'author': 'Gibbs RB', 'year': '2001'} / Neuroplasticity, development, and steroid hormone action by Gibbs RB (2001)
10.1006/hbeh.2002.1825
10.1046/j.1365-2826.2003.01012.x
10.1016/S0306-4522(02)00239-7
10.1002/0470870818.ch18
10.1097/00019442-199821001-00002
10.1016/S0306-4522(00)00410-3
10.1002/14651858.CD003122
10.1002/14651858.CD003799
10.1046/j.1460-9568.2003.02637.x
10.1001/jama.285.11.1489
10.1007/s000180050318
10.1016/S1521-690X(02)00082-9
10.1523/JNEUROSCI.22-24-10985.2002 / J Neurosci / Effectiveness of estrogen replacement in restoration of cognitive function after long‐term estrogen withdrawal in aging rats by Markowska AL (2002)
10.1093/oxfordjournals.aje.a008678
10.1210/rp.57.1.357
10.1016/S0531-5565(02)00166-3
10.1523/JNEUROSCI.23-13-05708.2003
10.1523/JNEUROSCI.23-11-04479.2003 / J Neurosci / A role for the basal forebrain cholinergic system in estrogen‐induced disinhibition of hippocampal pyramidal cells by Rudick CN (2003)
10.1016/S0165-6147(02)02093-X
10.1001/jama.289.20.2651
10.1073/pnas.96.19.10893
10.1037/0735-7044.116.2.187
10.1001/jama.288.17.2123

Dates

Type	When
Created	21 years, 9 months ago (Nov. 18, 2003, 4:24 p.m.)
Deposited	1 year, 9 months ago (Nov. 17, 2023, 1:22 p.m.)
Indexed	7 hours, 41 minutes ago (Aug. 29, 2025, 5:51 a.m.)
Issued	21 years, 10 months ago (Oct. 21, 2003)
Published	21 years, 10 months ago (Oct. 21, 2003)
Published Online	21 years, 10 months ago (Oct. 21, 2003)
Published Print	21 years, 8 months ago (Dec. 1, 2003)

Funders 0

None

BibTeX

@article{Gibbs_2003, title={Estrogen and cognition: Applying preclinical findings to clinical perspectives}, volume={74}, ISSN={1097-4547}, url={http://dx.doi.org/10.1002/jnr.10811}, DOI={10.1002/jnr.10811}, number={5}, journal={Journal of Neuroscience Research}, publisher={Wiley}, author={Gibbs, Robert B. and Gabor, Rachel}, year={2003}, month=oct, pages={637–643} }

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