DOI: 10.1002/jnr.10342. Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia

Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia

10.1002/jnr.10342

Crossref journal-article

Wiley

Journal of Neuroscience Research (311)

Abstract

AbstractBoth nestin and the neural RNA‐binding protein Musashi1 (Msi1) are expressed in neural stem cells in the subventricular zone. Neurogenesis in the hippocampus has received much attention, so we evaluated the expression of Msi1 and nestin in the adult rat hippocampus after transient forebrain ischemia. Both Msi1 and nestin were induced in the reactive astrocytes after ischemia, especially in the CA1 region, until 35 days after ischemia. Induction of both molecules suggested that reactive astrocytes might have immature characteristics. In the subgranular zone (SGZ) of the hippocampal dentate gyrus, Msi1‐positive cells formed clusters after ischemia. These cells were labeled by bromodeoxyuridine (BrdU) but did not express glial fibrillary acidic protein. In contrast, very few nestin‐positive cells were labeled by BrdU. Our results suggest that neuronal progenitor cells in the SGZ expressed Msi1 but not nestin. © 2002 Wiley‐Liss, Inc.

Bibliography

Yagita, Y., Kitagawa, K., Sasaki, T., Miyata, T., Okano, H., Hori, M., & Matsumoto, M. (2002). Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia. Journal of Neuroscience Research, 69(6), 750â756. Portico.

Authors 7

Yoshiki Yagita (first)
Kazuo Kitagawa (additional)
Tsutomu Sasaki (additional)
Takaki Miyata (additional)
Hideyuki Okano (additional)
Masatsugu Hori (additional)
Masayasu Matsumoto (additional)

References 43 Referenced 39

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Dates

Type	When
Created	22 years, 10 months ago (Oct. 10, 2002, 9 a.m.)
Deposited	1 year, 11 months ago (Sept. 12, 2023, 4:42 a.m.)
Indexed	16 hours, 1 minute ago (Sept. 3, 2025, 6:45 a.m.)
Issued	23 years ago (Aug. 27, 2002)
Published	23 years ago (Aug. 27, 2002)
Published Online	23 years ago (Aug. 27, 2002)
Published Print	22 years, 11 months ago (Sept. 15, 2002)

Funders 0

None

BibTeX

@article{Yagita_2002, title={Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia}, volume={69}, ISSN={1097-4547}, url={http://dx.doi.org/10.1002/jnr.10342}, DOI={10.1002/jnr.10342}, number={6}, journal={Journal of Neuroscience Research}, publisher={Wiley}, author={Yagita, Yoshiki and Kitagawa, Kazuo and Sasaki, Tsutomu and Miyata, Takaki and Okano, Hideyuki and Hori, Masatsugu and Matsumoto, Masayasu}, year={2002}, month=aug, pages={750–756} }

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