DOI: 10.1002/jmr.300080605. Solution dynamics of the oligosaccharide moiety of ganglioside GM1: Comparison of solution conformations with the bound state conformation in association with cholera toxin B‐pentamer

Solution dynamics of the oligosaccharide moiety of ganglioside GM1: Comparison of solution conformations with the bound state conformation in association with cholera toxin B‐pentamer

10.1002/jmr.300080605

Crossref journal-article

Wiley

Journal of Molecular Recognition (311)

Abstract

AbstractThe solution dynamics of the oligosaccharide moiety of ganglioside GM1 have been determined by use of a combination of 1H rotating frame Overhauser effect measurements and restrained molecular dynamics simulations, It is found that the Galβ1‐3 and NeuNAc moieties which are primarily recognized by cholera toxin both exhibit considerable torsional flexibility about their respective glycosidic linkages. A comparison with the bound state conformation of the ganglioside in association with cholera toxin B‐pentamer, shows that a low energy conformation of the oligosaccharide, which closely approximates the globel minimum, is selected upon binding.

Bibliography

Richardson, J. M., Milton, M. J., & Homans, S. W. (1995). Solution dynamics of the oligosaccharide moiety of ganglioside GM1: Comparison of solution conformations with the bound state conformation in association with cholera toxin Bâpentamer. Journal of Molecular Recognition, 8(6), 358â362. Portico.

Authors 3

Julia M. Richardson (first)
Mark J. Milton (additional)
Steve W. Homans (additional)

References 15 Referenced 5

10.1021/ja00177a043
10.1016/S0021-9258(17)44732-6 / J. Biol. Chem. / X‐ray structure of a Manα‐1‐3Manβ1‐4GlcNAc‐Lectin complex at 2.1 Å resolution by Bourne Y. (1990)
Bourne Y. Rougé P.andCambillau C.(1990b). X‐ray Structure of a biantennary octasaccharide‐lectin complex at 2.3 Å resolution.J. Biol. Chem.197–203. (10.1016/S0021-9258(18)48479-7)
10.1126/science.1713710
10.1128/mr.47.4.596-620.1983
10.1002/jcc.540120303
10.1093/glycob/2.2.143
10.1007/BF00769847
10.1002/pro.5560030202
10.1021/ja00001a055
10.1021/bi00198a029
10.1093/glycob/4.1.59 / Glycobiology / Study of conformational transitions in the sialyl‐lewis X antigen by Rutherford T. J.
10.1139/v84-172
10.1063/1.439059
10.1093/infdis/124.4.415

Dates

Type	When
Created	20 years, 3 months ago (May 29, 2005, 6:38 a.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 10:51 p.m.)
Indexed	1 year, 10 months ago (Oct. 27, 2023, 12:57 a.m.)
Issued	29 years, 9 months ago (Nov. 1, 1995)
Published	29 years, 9 months ago (Nov. 1, 1995)
Published Online	21 years, 6 months ago (Feb. 3, 2004)
Published Print	29 years, 9 months ago (Nov. 1, 1995)

Funders 0

None

BibTeX

@article{Richardson_1995, title={Solution dynamics of the oligosaccharide moiety of ganglioside GM1: Comparison of solution conformations with the bound state conformation in association with cholera toxin B‐pentamer}, volume={8}, ISSN={1099-1352}, url={http://dx.doi.org/10.1002/jmr.300080605}, DOI={10.1002/jmr.300080605}, number={6}, journal={Journal of Molecular Recognition}, publisher={Wiley}, author={Richardson, Julia M. and Milton, Mark J. and Homans, Steve W.}, year={1995}, month=nov, pages={358–362} }

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