DOI: 10.1002/jmr.300070108. Structural and physicochemical analysis of the reaction between the anti‐lysozyme antibody D1.3 and the anti‐idiotopic antibodies E225 and E5.2

Structural and physicochemical analysis of the reaction between the anti‐lysozyme antibody D1.3 and the anti‐idiotopic antibodies E225 and E5.2

10.1002/jmr.300070108

Crossref journal-article

Wiley

Journal of Molecular Recognition (311)

Abstract

AbstractThe reaction between the mouse (BALB/c) anti‐idiotiopic monoclonal antibodies E225 and E5.2 and idiotopes on the (BALB/c) anti‐lysozyme monoclonal antibody D1.3 has been characterized by titration calorimetry, by equilibrium sedimentation and by the determination of binding association and dissociation rates. The reaction between E5.2 and D1.3 is driven by a large negative enthalpy and its rate and equilibrium association constants are comparable to those observed in other antigen–antibody reactions. In contrast, the reaction between E225 and D1.3 is entropically driven and characterized by slow association kinetic (1 × 103 M−1 sec−1) and a resulting low equilibrium constant (Ka = 2 × 105M−1). A correlation of these properties with the three‐dimensional structure of the Fab225‐FabD1.3 complex, previously determined by X‐ray diffraction methods to 2.5 Å resolution, indicates that conformational changes of several D1.3 contacting residues, located in its complementarity determining regions, may explain these features of the reaction.

Bibliography

Tello, D., Eisenstein, E., Schwarz, F. P., Goldbaum, F. A., Fields, B. A., Mariuzza, R. A., & Poljak, R. J. (1994). Structural and physicochemical analysis of the reaction between the antiâlysozyme antibody D1.3 and the antiâidiotopic antibodies E225 and E5.2. Journal of Molecular Recognition, 7(1), 57â62. Portico.

Authors 7

Diana Tello (first)
Edward Eisenstein (additional)
Frederick P. Schwarz (additional)
Fernando A. Goldbaum (additional)
Barry A. Fields (additional)
Roy A. Mariuzza (additional)
Roberto J. Poljak (additional)

References 26 Referenced 17

10.1126/science.2426778
10.1038/348254a0
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10.1073/pnas.91.3.1089
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{'key': 'e_1_2_1_7_1', 'volume-title': 'X‐PLOR version 3.1. A system for X‐ray crystallography and NMR', 'author': 'Brünger A. T.', 'year': '1993'} / X‐PLOR version 3.1. A system for X‐ray crystallography and NMR by Brünger A. T. (1993)
10.1073/pnas.90.16.7711
10.1146/annurev.iy.04.040186.001051
10.1016/S0021-9258(18)67165-0 / J. Biol. Chem. / Regulation of arginine metabolism in Saccharomyces cerevisiae: association of arginase and ornithine transcarbomylase by Eisenstein E. (1986)
10.1016/S0021-9258(18)98782-X / J. Biol. Chem. / Crystallographic refinement of the three‐dimensional structure of the FabD1.3–lysozyme complex at 2.5 Å resolution by Fischmann T. O. (1991)
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{'key': 'e_1_2_1_13_1', 'first-page': '373', 'article-title': 'Towards a network theory of the immune system', 'volume': '125', 'author': 'Jerne N. K.', 'year': '1974', 'journal-title': 'Ann. Immunol. Inst. Pasteur'} / Ann. Immunol. Inst. Pasteur / Towards a network theory of the immune system by Jerne N. K. (1974)
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10.1016/0161-5890(90)90167-X
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10.1084/jem.132.2.211

Dates

Type	When
Created	20 years, 3 months ago (May 29, 2005, 6:33 a.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 8 p.m.)
Indexed	1 year, 10 months ago (Oct. 24, 2023, 7:13 a.m.)
Issued	31 years, 6 months ago (March 1, 1994)
Published	31 years, 6 months ago (March 1, 1994)
Published Online	21 years, 7 months ago (Feb. 3, 2004)
Published Print	31 years, 6 months ago (March 1, 1994)

Funders 0

None

BibTeX

@article{Tello_1994, title={Structural and physicochemical analysis of the reaction between the anti‐lysozyme antibody D1.3 and the anti‐idiotopic antibodies E225 and E5.2}, volume={7}, ISSN={1099-1352}, url={http://dx.doi.org/10.1002/jmr.300070108}, DOI={10.1002/jmr.300070108}, number={1}, journal={Journal of Molecular Recognition}, publisher={Wiley}, author={Tello, Diana and Eisenstein, Edward and Schwarz, Frederick P. and Goldbaum, Fernando A. and Fields, Barry A. and Mariuzza, Roy A. and Poljak, Roberto J.}, year={1994}, month=mar, pages={57–62} }

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