DOI: 10.1002/jlcr.1052. One‐pot synthesis of [<sup>11</sup>C]ureas via triphenylphosphinimines

One‐pot synthesis of [11C]ureas via triphenylphosphinimines

10.1002/jlcr.1052

Crossref journal-article

Wiley

Journal of Labelled Compounds and Radiopharmaceuticals (311)

Abstract

AbstractA series of 11C‐labeled ureas was prepared using a rapid and efficient one‐pot procedure. First, the intermediate [11C]phenylisocyanate was formed with phenyltriphenylphosphinimine and [11C]CO2. A range of amines was then reacted with the [11C]phenylisocyanate yielding the [11C]urea derivatives in short synthesis times. This easy‐to‐handle method circumvents disadvantages of known procedures and generates the possibility to prepare other kinds of 11C‐labeled compounds using a variety of phenylphosphinimines in combination with different nucleophiles. The presented approach is an alternative to the use of established methods in 11C‐labeling chemistry. Copyright © 2006 John Wiley & Sons, Ltd.

Bibliography

van Tilburg, E. W., Windhorst, A. D., van der Mey, M., & Herscheid, J. D. M. (2006). Oneâpot synthesis of [11C]ureas via triphenylphosphinimines. Journal of Labelled Compounds and Radiopharmaceuticals, 49(4), 321â330. Portico.

Authors 4

Erica W. van Tilburg (first)
Albert D. Windhorst (additional)
Margreet van der Mey (additional)
Jacobus D. M. Herscheid (additional)

References 41 Referenced 34

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{'key': 'e_1_2_1_23_2', 'first-page': 'S74', 'volume': '46', 'author': 'Brichard L', 'year': '2003', 'journal-title': 'J Label Compd Radiopharm'} / J Label Compd Radiopharm by Brichard L (2003)
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Dates

Type	When
Created	19 years, 6 months ago (Feb. 20, 2006, 1:47 p.m.)
Deposited	1 year, 9 months ago (Nov. 15, 2023, 10:24 a.m.)
Indexed	1 year, 2 months ago (June 8, 2024, 3:16 p.m.)
Issued	19 years, 6 months ago (Feb. 20, 2006)
Published	19 years, 6 months ago (Feb. 20, 2006)
Published Online	19 years, 6 months ago (Feb. 20, 2006)
Published Print	19 years, 5 months ago (March 30, 2006)

Funders 0

None

BibTeX

@article{van_Tilburg_2006, title={One‐pot synthesis of [11C]ureas via triphenylphosphinimines}, volume={49}, ISSN={1099-1344}, url={http://dx.doi.org/10.1002/jlcr.1052}, DOI={10.1002/jlcr.1052}, number={4}, journal={Journal of Labelled Compounds and Radiopharmaceuticals}, publisher={Wiley}, author={van Tilburg, Erica W. and Windhorst, Albert D. and van der Mey, Margreet and Herscheid, Jacobus D. M.}, year={2006}, month=feb, pages={321–330} }

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