DOI: 10.1002/jlb.67.2.206. Langerhans cells acquire a CD8+ dendritic cell phenotype on maturation by CD40 ligation

Langerhans cells acquire a CD8+ dendritic cell phenotype on maturation by CD40 ligation

10.1002/jlb.67.2.206

Crossref journal-article

Oxford University Press (OUP)

Journal of Leukocyte Biology (286)

Abstract

Abstract Dendritic cell (DC) reconstitution experiments and phenotypic analysis of DC subpopu-lations have allowed the definition in the mouse of two main DC categories: CD8+ lymphoid DCs and CD8− myeloid DCs. With regard to Langerhans cells (LCs), which represent immature DCs differentiating into mature DCs on migration to the lymph nodes after an antigenic stimulation, although classically considered as myeloid DCs, there is no experimental evidence of their origin. It has been recently shown that mouse LCs, negative for CD8 and LFA-1, undergo CD8/LFA-1 up-regulation on migration, suggesting that LCs belong to the CD8+ lymphoid DC lineage. To further reinforce this hypothesis, we have analyzed the modulation of CD8 expression by LCs on culture with molecules known to induce LC maturation. Our results show that LC acquired a CD8+ lymphoid phenotype on CD40 ligation. J. Leukoc. Biol. 67: 206–209; 2000.

Bibliography

Anjuere, F., del Hoyo, G. M., MartÃn, P., & ArdavÃn, C. (2000). Langerhans cells acquire a CD8+ dendritic cell phenotype on maturation by CD40 ligation. Journal of Leukocyte Biology, 67(2), 206â209.

Authors 4

Fabienne Anjuere (first)
Gloria Martínez del Hoyo (additional)
Pilar Martín (additional)
Carlos Ardavín (additional)

References 0 Referenced 43

None

Dates

Type	When
Created	7 years, 7 months ago (Jan. 12, 2018, 1:43 p.m.)
Deposited	2 years, 4 months ago (March 30, 2023, 7:51 p.m.)
Indexed	1 year, 3 months ago (May 10, 2024, 8:09 a.m.)
Issued	25 years, 6 months ago (Feb. 1, 2000)
Published	25 years, 6 months ago (Feb. 1, 2000)
Published Online	25 years, 6 months ago (Feb. 1, 2000)
Published Print	25 years, 6 months ago (Feb. 1, 2000)

Funders 0

None

BibTeX

@article{Anjuere_2000, title={Langerhans cells acquire a CD8+ dendritic cell phenotype on maturation by CD40 ligation}, volume={67}, ISSN={1938-3673}, url={http://dx.doi.org/10.1002/jlb.67.2.206}, DOI={10.1002/jlb.67.2.206}, number={2}, journal={Journal of Leukocyte Biology}, publisher={Oxford University Press (OUP)}, author={Anjuere, Fabienne and del Hoyo, Gloria Martínez and Martín, Pilar and Ardavín, Carlos}, year={2000}, month=feb, pages={206–209} }

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