DOI: 10.1002/jlb.65.1.6. Chemokines: signal lamps for trafficking of T and B cells for development and effector function

Chemokines: signal lamps for trafficking of T and B cells for development and effector function

10.1002/jlb.65.1.6

Crossref journal-article

Oxford University Press (OUP)

Journal of Leukocyte Biology (286)

Abstract

Abstract Chemokines can act as signal lamps for trafficking of lymphocytes at the important crossing points of lymphoid tissues. Lymphoid progenitors at different differentiation stages are differentially localized in primary lymphoid tissues and have differential responsiveness to thymic or bone marrow chemokines: SDF-1, CKβ-11/MIP-3β/ELC, SLC/6Ckine/Exodus2, MIP-1β, and TECK. Naive T cells and B cells circulate to secondary lymphoid tissues for possible activation. Chemokines, SDF-1, SLC/6Ckine/Exodus2, CKβ-11/MIP-3β/ELC, BLC/BCA-1, and DC-CK1/PARC, are expressed in the specialized microenvironments of secondary lymphoid tissues and regulate the migration of naive lymphocytes. Effector lymphocytes express a different set of chemokine receptors from naive lymphocytes. T helper (Th) 0 and 1 cells predominantly express CXCR3 and CCR5, whereas Th2 cells express CCR3, CCR4, and CCR8, which, with other factors such as expression patterns of adhesion molecules, likely determine the tissue- specific infiltration of effector lymphocytes. J. Leukoc. Biol. 65: 6–15; 1999.

Bibliography

Kim, C. H., & Broxmeyer, H. E. (1999). Chemokines: signal lamps for trafficking of T and B cells for development and effector function. Journal of Leukocyte Biology, 65(1), 6â15.

Authors 2

Chang H Kim (first)
Hal E Broxmeyer (additional)

References 0 Referenced 274

None

Dates

Type	When
Created	7 years, 7 months ago (Jan. 12, 2018, 1:59 p.m.)
Deposited	2 years, 4 months ago (April 5, 2023, 12:32 a.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 9:18 p.m.)
Issued	26 years, 7 months ago (Jan. 1, 1999)
Published	26 years, 7 months ago (Jan. 1, 1999)
Published Online	26 years, 7 months ago (Jan. 1, 1999)
Published Print	26 years, 7 months ago (Jan. 1, 1999)

Funders 0

None

BibTeX

@article{Kim_1999, title={Chemokines: signal lamps for trafficking of T and B cells for development and effector function}, volume={65}, ISSN={1938-3673}, url={http://dx.doi.org/10.1002/jlb.65.1.6}, DOI={10.1002/jlb.65.1.6}, number={1}, journal={Journal of Leukocyte Biology}, publisher={Oxford University Press (OUP)}, author={Kim, Chang H and Broxmeyer, Hal E}, year={1999}, month=jan, pages={6–15} }

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