DOI: 10.1002/jlb.61.1.6. Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades

Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades

10.1002/jlb.61.1.6

Crossref journal-article

Oxford University Press (OUP)

Journal of Leukocyte Biology (286)

Abstract

Abstract Signal transduction by the T cell and B cell antigen receptors and by receptors for a variety of immunoglobulins' Fc region is strictly dependent on a receptor subunit cytoplasmic module termed immunoreceptor tyrosine-based activation motif (FE4M). Hris module exists in one or more copies in each of the receptor-associated signal-transducing molecules and it possesses two repeats of the consensus sequence Tyr-X-X-Leu/IIe spaced by six to eight amino acids. Receptor engagement is followed by a rapid and transient phosphorylation of tyrosine residues within their ITAMs, thereby creating temporary binding sites for Src homology 2 (SH2)-containing signaling molecules operating downstream of the activated receptor. The purpose of this review is to discuss recent findings on the functional role of ITAMs in antigen and Fc receptor-mediated signal transduction, with a particular emphasis on kinases operating upstream and downstream of the ITAMs.

Bibliography

Isakov, N. (1997). Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades. Journal of Leukocyte Biology, 61(1), 6â16.

Authors 1

Noah Isakov (first)

References 0 Referenced 88

None

Dates

Type	When
Created	7 years, 7 months ago (Jan. 12, 2018, 2:02 p.m.)
Deposited	2 years, 4 months ago (April 5, 2023, 2:20 a.m.)
Indexed	3 months, 1 week ago (May 18, 2025, 12:04 p.m.)
Issued	28 years, 7 months ago (Jan. 1, 1997)
Published	28 years, 7 months ago (Jan. 1, 1997)
Published Online	28 years, 7 months ago (Jan. 1, 1997)
Published Print	28 years, 7 months ago (Jan. 1, 1997)

Funders 0

None

BibTeX

@article{Isakov_1997, title={Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades}, volume={61}, ISSN={1938-3673}, url={http://dx.doi.org/10.1002/jlb.61.1.6}, DOI={10.1002/jlb.61.1.6}, number={1}, journal={Journal of Leukocyte Biology}, publisher={Oxford University Press (OUP)}, author={Isakov, Noah}, year={1997}, month=jan, pages={6–16} }

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