DOI: 10.1002/jlb.45.4.345. Macrophage Activation for Cytolysis of Virally Infected Target Cells

Macrophage Activation for Cytolysis of Virally Infected Target Cells

10.1002/jlb.45.4.345

Crossref journal-article

Oxford University Press (OUP)

Journal of Leukocyte Biology (286)

Abstract

Abstract Bone-marrow-culture-derived macrophages killed virally infected cells but not uninfected cells. This activity could be enhanced by preexposure of the macrophages to lipopolysaccharide (LPS), and/or purified interferons. The ability to kill virally infected targets was not restricted to a single cell type or virus. Comparing the ability of activators to induce activity against virally infected targets or tumor (P815) targets, it was found that much lower levels of LPS or α/β-interferon were able to induce cytolytic activity for virally infected cells than were needed for tumor targets. Further, while the antitumor activity did not change significantly with an increase in the time of exposure to activating stimuli from 4 to 24 h, the activity against virally infected cells decreased dramatically with the longer exposure to stimuli.

Bibliography

LeBlanc, P. A. (1989). Macrophage Activation for Cytolysis of Virally Infected Target Cells. Journal of Leukocyte Biology, 45(4), 345â352.

Authors 1

Paul A LeBlanc (first)

References 0 Referenced 9

None

Dates

Type	When
Created	7 years, 7 months ago (Jan. 12, 2018, 2:47 p.m.)
Deposited	2 years, 4 months ago (April 3, 2023, 6:46 a.m.)
Indexed	2 years, 4 months ago (April 4, 2023, 12:23 a.m.)
Issued	36 years, 4 months ago (April 1, 1989)
Published	36 years, 4 months ago (April 1, 1989)
Published Online	36 years, 4 months ago (April 1, 1989)
Published Print	36 years, 4 months ago (April 1, 1989)

Funders 0

None

BibTeX

@article{LeBlanc_1989, title={Macrophage Activation for Cytolysis of Virally Infected Target Cells}, volume={45}, ISSN={1938-3673}, url={http://dx.doi.org/10.1002/jlb.45.4.345}, DOI={10.1002/jlb.45.4.345}, number={4}, journal={Journal of Leukocyte Biology}, publisher={Oxford University Press (OUP)}, author={LeBlanc, Paul A}, year={1989}, month=apr, pages={345–352} }

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