DOI: 10.1002/jhet.5570400521. Synthesis of novel 3,4‐dihydropyrimidinones on water soluble solid support catalyzed by indium triflate

Synthesis of novel 3,4‐dihydropyrimidinones on water soluble solid support catalyzed by indium triflate

10.1002/jhet.5570400521

Crossref journal-article

Wiley

Journal of Heterocyclic Chemistry (311)

Abstract

AbstractSyntheses of several new 3,4‐dihydropyrimidinones (DHPMs) on sodium sulfate solid support have been reported. The microwave enhanced rapid synthesis of the title compounds yielded a good percentage of the DHPMs. The catalytic activity of indium triflate enables to prepare a wide range of DHPMs. Syntheses of 2‐hydroxyphenyl, 2‐hydroxy‐4‐methoxyphenyl pendant groups on DHPMs scaffold are advantages of the present method, which are rather prone towards cyclization and the presence of free hydroxyl groups on the phenyl ring is confirmed via D2O exchange study. The mechanism of the reaction is expected to proceed via absorption of substrates on the solid support followed by promotion of the reaction by In(OTf)3 coupled with microwave irradiation.

Bibliography

Shanmugam, P., Annie, G., & Perumal, P. T. (2003). Synthesis of novel 3,4âdihydropyrimidinones on water soluble solid support catalyzed by indium triflate. Journal of Heterocyclic Chemistry, 40(5), 879â883. Portico.

Authors 3

P. Shanmugam (first)
G. Annie (additional)
P. T. Perumal (additional)

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Dates

Type	When
Created	16 years, 4 months ago (April 23, 2009, 5:14 p.m.)
Deposited	1 year, 9 months ago (Nov. 16, 2023, 2:59 p.m.)
Indexed	1 month, 4 weeks ago (July 2, 2025, 2:13 p.m.)
Issued	22 years ago (Sept. 1, 2003)
Published	22 years ago (Sept. 1, 2003)
Published Online	16 years, 4 months ago (April 23, 2009)
Published Print	22 years ago (Sept. 1, 2003)

Funders 0

None

BibTeX

@article{Shanmugam_2003, title={Synthesis of novel 3,4‐dihydropyrimidinones on water soluble solid support catalyzed by indium triflate}, volume={40}, ISSN={1943-5193}, url={http://dx.doi.org/10.1002/jhet.5570400521}, DOI={10.1002/jhet.5570400521}, number={5}, journal={Journal of Heterocyclic Chemistry}, publisher={Wiley}, author={Shanmugam, P. and Annie, G. and Perumal, P. T.}, year={2003}, month=sep, pages={879–883} }

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