DOI: 10.1002/jez.1402150208. Responses of denervated adult newt limb stumps to reinnervation and reinjury

Responses of denervated adult newt limb stumps to reinnervation and reinjury

10.1002/jez.1402150208

Crossref journal-article

Wiley

Journal of Experimental Zoology (311)

Abstract

AbstractIt is well known that denervated adult newt limbs do not regenerate. Not understood is why denervated newt limb stumps fail to initiate regeneration upon reinnervation. In an effort to define the regeneration limiting factors, we examined the histology of long‐term denervated newt limb stumps and tested the effects of various kinds of reinjury. In 5‐week denervated limb stumps there were present dedifferentiated cells, differentiated cartilage, and densely packed layered cells. The epidermis covering the limb tip resembled skin epidermis rather than wound epidermis. The kinds of reinjury that were successful in restoring the regeneration capabilities to 5‐week denervated limb stumps included: reamputation (100%), a single razor incision (60%), and removal of the healed tissues from the distal limb tip (70%). The results of this study emphasize the importance of both injury and wound epidermis in initiating regeneration.

Bibliography

Salley, J. D., & Tassava, R. A. (1981). Responses of denervated adult newt limb stumps to reinnervation and reinjury. Journal of Experimental Zoology, 215(2), 183â189. Portico.

Authors 2

Judith D. Salley (first)
Roy A. Tassava (additional)

References 26 Referenced 28

10.1002/jez.1400880208
{'key': 'e_1_2_1_3_1', 'first-page': '60', 'volume-title': 'Neoplasia and Cell Differentiation', 'author': 'Carlson B. M.', 'year': '1974'} / Neoplasia and Cell Differentiation by Carlson B. M. (1974)
10.1093/icb/18.4.869 / Am. Zool. / Types of morphogenetic phenomena in vertebrate regenerating systems by Carlson B. M. (1978)
10.1002/ar.1091260303
{'key': 'e_1_2_1_6_1', 'volume-title': 'Regeneration', 'author': 'Hay E. D.', 'year': '1966'} / Regeneration by Hay E. D. (1966)
10.1002/jez.1402140109
10.1002/jez.1401950111
10.1016/0012-1606(75)90386-3
10.1007/BF01965826
{'key': 'e_1_2_1_11_1', 'first-page': '368', 'article-title': 'O protsessakh rezorbtsii, proliferatsii i sootnoshenii tkanei pri regeneratsii konechnostei u aksolotlei', 'volume': '2', 'author': 'Polezhaev L. V.', 'year': '1933', 'journal-title': 'Biol. Zhur.'} / Biol. Zhur. / O protsessakh rezorbtsii, proliferatsii i sootnoshenii tkanei pri regeneratsii konechnostei u aksolotlei by Polezhaev L. V. (1933)
10.1002/jez.1400950202
10.1002/ar.1091160410
10.2307/1538866
10.1086/398873
10.1093/icb/18.4.829
10.1002/jez.1401080207
10.1002/jez.1401110208
10.1002/jez.1401550108
{'key': 'e_1_2_1_20_1', 'first-page': '277', 'volume-title': 'Growth in Living Systems', 'author': 'Singer M.', 'year': '1961'} / Growth in Living Systems by Singer M. (1961)
10.1002/jmor.1051500106
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10.1002/jez.1402080111
10.1038/268049a0
10.1093/icb/18.4.843
10.1111/j.1432-0436.1975.tb01439.x
{'key': 'e_1_2_1_27_1', 'volume-title': 'Advances in Morphogenesis', 'author': 'Thornton C. S.', 'year': '1968'} / Advances in Morphogenesis by Thornton C. S. (1968)

Dates

Type	When
Created	20 years, 2 months ago (June 11, 2005, 4:14 a.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 5:52 a.m.)
Indexed	1 year, 1 month ago (July 13, 2024, 2:38 a.m.)
Issued	44 years, 7 months ago (Feb. 1, 1981)
Published	44 years, 7 months ago (Feb. 1, 1981)
Published Online	20 years, 3 months ago (June 1, 2005)
Published Print	44 years, 7 months ago (Feb. 1, 1981)

Funders 0

None

BibTeX

@article{Salley_1981, title={Responses of denervated adult newt limb stumps to reinnervation and reinjury}, volume={215}, ISSN={1097-010X}, url={http://dx.doi.org/10.1002/jez.1402150208}, DOI={10.1002/jez.1402150208}, number={2}, journal={Journal of Experimental Zoology}, publisher={Wiley}, author={Salley, Judith D. and Tassava, Roy A.}, year={1981}, month=feb, pages={183–189} }

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