DOI: 10.1002/jez.1401750404. Mammalian lung development: Interactions in primordium formation and bronchial morphogenesis

Mammalian lung development: Interactions in primordium formation and bronchial morphogenesis

10.1002/jez.1401750404

Crossref journal-article

Wiley

Journal of Experimental Zoology (311)

Abstract

AbstractThe manner in which mouse lung primordia form has been analyzed by observation of trypsin‐isolated gut endoderm from nine‐day embryos. The tissue interactions involved in initial formation of lung primordia and those involved in subsequent morphogenesis of the primordia have been investigated by various organ culture procedures. Mouse lungs form in a manner different from that generally described for amniote embryos. Thus, two lung buds appear first and form the primary bronchi, whereas the trachea appears secondarily.The initial lung buds form at the 25–27 somite stage. Whole‐guts from embryos as young as the two‐somite stage form lung buds in culture. Such buds do not undergo branching morphogenesis if the guts are taken from embryos younger than the 25‐somite stage, but undergo characteristic dichotomous branching if combined with older bronchial mesoderm. If 20–25 somite‐stage endoderm is isolated and cultured in direct combination with gut, older salivary or older bronchial mesoderms, lung buds form. However, such buds only branch in combinations containing bronchial mesoderm. Our results reveal two levels of mesodermal control of lung development. Interactions between nonspecific mesoderm and gut endoderm result in lung bud formation, while those between specific bronchial mesoderm and bud endoderm are required for branching morphogenesis.

Bibliography

Spooner, B. S., & Wessells, N. K. (1970). Mammalian lung development: Interactions in primordium formation and bronchial morphogenesis. Journal of Experimental Zoology, 175(4), 445â454. Portico.

Authors 2

Brian S. Spooner (first)
Norman K. Wessells (additional)

References 17 Referenced 199

10.1002/jez.1401500202
{'key': 'e_1_2_1_3_1', 'first-page': '493', 'volume-title': 'Methods in Developmental Biology', 'author': 'Cahn R. D.', 'year': '1967'} / Methods in Developmental Biology by Cahn R. D. (1967)
{'key': 'e_1_2_1_4_1', 'first-page': '628', 'article-title': "L'influence de divers mésenchymes sur la differentiation de l'epithelium pulmonaire de l'embryon de poulet en culture in vitro", 'volume': '9', 'author': 'Dameron F.', 'year': '1961', 'journal-title': 'J. Embryol. Exp. Morphol.'} / J. Embryol. Exp. Morphol. / L'influence de divers mésenchymes sur la differentiation de l'epithelium pulmonaire de l'embryon de poulet en culture in vitro by Dameron F. (1961)
10.1007/BF00525226
{'key': 'e_1_2_1_6_1', 'first-page': '224', 'volume-title': "Lillie's Development of the Chick", 'author': 'Hamilton H. L.', 'year': '1952'} / Lillie's Development of the Chick by Hamilton H. L. (1952)
10.1086/280493
10.1016/0012-1606(69)90004-9
{'key': 'e_1_2_1_9_1', 'first-page': '205', 'volume-title': 'Medical Embryology', 'author': 'Langman J.', 'year': '1963'} / Medical Embryology by Langman J. (1963)
{'key': 'e_1_2_1_10_1', 'first-page': '651', 'article-title': "Induction de l'endoderme pré‐hépatique par le mésoderme de l'aire cardaique chez l'embryon de poulet", 'volume': '12', 'author': 'Le Douarin N.', 'year': '1964', 'journal-title': 'J. Embryol. Exp. Morphol.'} / J. Embryol. Exp. Morphol. / Induction de l'endoderme pré‐hépatique par le mésoderme de l'aire cardaique chez l'embryon de poulet by Le Douarin N. (1964)
{'key': 'e_1_2_1_11_1', 'first-page': '239', 'volume-title': 'Foundations of Embryology', 'author': 'Patten B. M.', 'year': '1964'} / Foundations of Embryology by Patten B. M. (1964)
{'key': 'e_1_2_1_12_1', 'first-page': '546', 'volume-title': 'The Avian Embryo: Structural and Functional Development', 'author': 'Romanoff A. L.', 'year': '1960'} / The Avian Embryo: Structural and Functional Development by Romanoff A. L. (1960)
10.1002/jcp.1040750105
Spooner B. S. B. T.WaltherandW. J.Rutter1970The development of the dorsal and ventral mammalian pancreasin vivoandin vitro.J. Cell Biol. in press. (10.1083/jcb.47.1.235)
10.1016/0012-1606(67)90061-9
{'key': 'e_1_2_1_16_1', 'first-page': '445', 'volume-title': 'Methods in Developmental Biology', 'author': 'Wessells N. K.', 'year': '1967'} / Methods in Developmental Biology by Wessells N. K. (1967)
10.1002/jez.1401750405
10.1016/0012-1606(67)90042-5

Dates

Type	When
Created	20 years, 2 months ago (June 11, 2005, 7:17 a.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 6:56 a.m.)
Indexed	4 months, 1 week ago (April 22, 2025, 2:45 a.m.)
Issued	54 years, 9 months ago (Dec. 1, 1970)
Published	54 years, 9 months ago (Dec. 1, 1970)
Published Online	20 years, 3 months ago (June 1, 2005)
Published Print	54 years, 9 months ago (Dec. 1, 1970)

Funders 0

None

BibTeX

@article{Spooner_1970, title={Mammalian lung development: Interactions in primordium formation and bronchial morphogenesis}, volume={175}, ISSN={1097-010X}, url={http://dx.doi.org/10.1002/jez.1401750404}, DOI={10.1002/jez.1401750404}, number={4}, journal={Journal of Experimental Zoology}, publisher={Wiley}, author={Spooner, Brian S. and Wessells, Norman K.}, year={1970}, month=dec, pages={445–454} }

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