DOI: 10.1002/jez.1401720207. Degeneration and regeneration in abdominal flexor motor neurons in the crayfish

Degeneration and regeneration in abdominal flexor motor neurons in the crayfish

10.1002/jez.1401720207

Crossref journal-article

Wiley

Journal of Experimental Zoology (311)

Abstract

AbstractElectrophysiological studies of sectioned crayfish motor axons of the abdominal flexor muscle have demonstrated that the distal stumps, isolated from their central connections for up to several months, are remarkably resistant to degeneration, as previously shown in the crayfish claw opener preparation. These distal stumps remained electrically excitable and intracellular recording showed that their neuromuscular junctional properties were indistinguishable from normal ones in such properties as waveform and amplitudes of the evoked junctional potentials. Furthermore, repetitive stimulation of the distal stumps evoked jp's which showed facilitation as in normal preparations. When degeneration finally occurred, electrical stimulation of the nerve no longer evoked jp's, and no progressive deterioration of junctional properties was observed.Regeneration ultimately occurred in these nerves but required at least three weeks or more. The electrical properties of these regenerated junctions were not different from normal ones.The evidence from time‐course and correlated histological studies of degeneration and regeneration suggest that regeneration of these crayfish nerves occurs by axonal fusion rather than by outgrowth of an entirely new distal apparatus from centrally located cell bodies, as is the mechanism in vertebrates and some invertebrates.

Bibliography

Hoy, R. R. (1969). Degeneration and regeneration in abdominal flexor motor neurons in the crayfish. Journal of Experimental Zoology, 172(2), 219â232. Portico.

Authors 1

Ronald R. Hoy (first)

References 30 Referenced 43

10.1016/0014-4886(63)90093-1
10.1113/jphysiol.1960.sp006379
10.1002/jez.1401360107
{'key': 'e_1_2_1_5_1', 'volume-title': 'Structure and Function in the Nervous Systems of Invertebrates', 'author': 'Bullock T. H.', 'year': '1965'} / Structure and Function in the Nervous Systems of Invertebrates by Bullock T. H. (1965)
10.1007/BF00637179 / Naturwissenschaften / Structural and functional correlation in crab muscle fibers by Raj B. S. Dorai (1964)
{'key': 'e_1_2_1_7_1', 'first-page': '357', 'article-title': 'Changes in membrane properties of crayfish muscle fibers caused by denervation', 'volume': '21', 'author': 'Girardier L.', 'year': '1962', 'journal-title': 'Fed. Proc.'} / Fed. Proc. / Changes in membrane properties of crayfish muscle fibers caused by denervation by Girardier L. (1962)
10.1016/0022-1910(67)90181-3
10.3181/00379727-34-8647C
10.1002/jmor.1051030304
10.1083/jcb.7.2.339
{'key': 'e_1_2_1_12_1', 'first-page': '2482', 'article-title': 'Degeneration and regeneration in the crayfish abdominal flexor system', 'volume': '50', 'author': 'Hoy R. R.', 'year': '1967', 'journal-title': 'J. Gen. Physiol.'} / J. Gen. Physiol. / Degeneration and regeneration in the crayfish abdominal flexor system by Hoy R. R. (1967)
10.1126/science.156.3772.251
10.1113/jphysiol.1965.sp007571
10.1152/jn.1966.29.6.1096 / J. Neurophysiol. / Properties of frog sympathetic neurons in normal ganglia and after axon section by Hunt C. C. (1966)
10.1126/science.156.3782.1640
10.1016/0014-4886(65)90022-1
10.1242/jeb.43.2.211 / J. Exp. Biol. / Reflex control of abdominal flexor muscles in the crayfish. I. The twitch system by Kennedy D. (1965)
10.1242/jeb.43.2.229 / J. Exp. Biol. / Reflex control of abdominal flexor muscles in the crayfish. II. The tonic system by Kennedy D. (1965)
10.1007/BF00348592 / Naunyn‐Schmiedebergs Arch. exp. Path. u. Pharmak. / Glial cells in the central nervous system of the leech; their membrane potential and potassium content by Kuffler S. W. (1964)
10.1152/jn.1966.29.4.768 / J. Neurophysiol. / Physiological properties of glial cells in the central nervous sustem of amphigia by Kuffler S. W. (1966)
{'key': 'e_1_2_1_22_1', 'volume-title': 'Degeneration and Regeneration of the Nervous System', 'author': 'y Cajal S. Ramón', 'year': '1928'} / Degeneration and Regeneration of the Nervous System by y Cajal S. Ramón (1928)
10.1242/jeb.27.1.1a / J. Exp. Biol. / The electrical and mechanical events of neuromuscular transmission in the cockroach, Periplaneta americana by Roeder K. A. (1950)
10.1038/2101225a0
10.3109/13813453509144107
10.1016/0022-1910(63)90076-3
10.1016/0022-1910(63)90040-4
{'key': 'e_1_2_1_28_1', 'volume-title': 'The Physiology of Crustacea, II', 'author': 'Wiersma C. A. G.', 'year': '1960'} / The Physiology of Crustacea, II by Wiersma C. A. G. (1960)
{'key': 'e_1_2_1_29_1', 'first-page': '219', 'article-title': 'Innervation patterns of crustacean limbs', 'volume': '2', 'author': 'Wiersma C. A. G.', 'year': '1952', 'journal-title': 'Physiol. Comp. et Oecol.'} / Physiol. Comp. et Oecol. / Innervation patterns of crustacean limbs by Wiersma C. A. G. (1952)
10.1242/jeb.37.1.57 / J. Exp. Biol. / Nervous control of movement in cephalopods by Wilson D. M. (1960)
10.1152/physrev.1942.22.4.318 / Physiol. Rev. / The functional repair of nervous tissue by Young J. Z. (1942)

Dates

Type	When
Created	20 years, 2 months ago (June 11, 2005, 7:11 a.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 1:13 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 11, 2024, 8:35 p.m.)
Issued	55 years, 11 months ago (Oct. 1, 1969)
Published	55 years, 11 months ago (Oct. 1, 1969)
Published Online	20 years, 3 months ago (June 1, 2005)
Published Print	55 years, 11 months ago (Oct. 1, 1969)

Funders 0

None

BibTeX

@article{Hoy_1969, title={Degeneration and regeneration in abdominal flexor motor neurons in the crayfish}, volume={172}, ISSN={1097-010X}, url={http://dx.doi.org/10.1002/jez.1401720207}, DOI={10.1002/jez.1401720207}, number={2}, journal={Journal of Experimental Zoology}, publisher={Wiley}, author={Hoy, Ronald R.}, year={1969}, month=oct, pages={219–232} }

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