DOI: 10.1002/jcp.1041090213. The synthesis of protein(S) for chromosome condensation may be regulated by a post‐transcriptional mechanism

The synthesis of protein(S) for chromosome condensation may be regulated by a post‐transcriptional mechanism

10.1002/jcp.1041090213

Crossref journal-article

Wiley

Journal of Cellular Physiology (311)

Abstract

AbstractA temperature sensitive mutant of BHK21, tsBN2, showed a premature chromosome condensation (PCC) upon the temperature shift of 40.5°, even in the absence of DNA replication. The induction of PCC requires new protein synthesis, but not necessarily new RNA synthesis. Our data suggested that the messenger RNA for chromosome condensation starts to be transcribed at the beginning of Sphase. At the permissive temperature (33.5°), the messenger RNA for chromosome condensation translated with a very slow rate during S phase and rapidly in G2‐M phase. At the nonpermissive temperature (40.5°), however, those messenger RNAs were translated anytime, so that various figures of PCC appeared depending on the cell cycle. On the way of PCC induction, ribosomal RNA synthesis was inhibited at first, as expected from mitosis. Our data suggested that the synthesis of protein(s) for chromosome condensation was regulated by the post‐transcriptional mechanism, in which tsBN2 might be defective, especially at the translational level.

Bibliography

Nishimoto, T., Ishida, R., Ajiro, K., Yamamoto, S., & Takahashi, T. (1981). The synthesis of protein(S) for chromosome condensation may be regulated by a postâtranscriptional mechanism. Journal of Cellular Physiology, 109(2), 299â308. Portico.

Authors 5

Takeharu Nishimoto (first)
Ryoji Ishida (additional)
Kozo Ajiro (additional)
Susumu Yamamoto (additional)
Taijo Takahashi (additional)

References 29 Referenced 40

{'key': 'e_1_2_1_2_1', 'first-page': '1218', 'article-title': 'The effect of bleomycin on survival and cell progression in Chinese hamster cells', 'volume': '31', 'author': 'Barranceo S. C.', 'year': '1971', 'journal-title': 'Cancer Res.'} / Cancer Res. / The effect of bleomycin on survival and cell progression in Chinese hamster cells by Barranceo S. C. (1971)
10.1016/0003-9861(59)90496-5
10.1016/S0021-9258(19)41488-9 / J. Biol. Chem. / Sequential phosphorylation of histone subfractions in the Chinese hamster cell cycle by Gurley L. R. (1975)
10.1016/0079-6107(78)90006-8
{'key': 'e_1_2_1_6_1', 'first-page': '3433', 'article-title': 'Bleomycin‐induced damage in prematurely condensed chromosomes and its relationship to cell cycle progression in CHO cells', 'volume': '34', 'author': 'Hittleman W. N.', 'year': '1974', 'journal-title': 'Cancer Res.'} / Cancer Res. / Bleomycin‐induced damage in prematurely condensed chromosomes and its relationship to cell cycle progression in CHO cells by Hittleman W. N. (1974)
10.1083/jcb.40.2.497
10.1247/csf.4.235
10.1038/275458a0
10.1038/226717a0
{'key': 'e_1_2_1_11_1', 'first-page': '320', 'volume-title': 'Gene Expression', 'author': 'Lewin B.', 'year': '1974'} / Gene Expression by Lewin B. (1974)
10.1083/jcb.47.2.453
10.1002/jcp.1040900102
10.1007/BF01542846
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10.1007/BF01539150
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10.1016/S0065-2660(08)60438-1
10.1093/jnci/57.5.1139
10.1002/jcp.1040910113
10.1016/B978-0-12-384650-1.50011-2 / Cell Cycle Regulation by Rao P. N. (1978)
10.1016/0092-8674(78)90144-7
10.1111/j.1601-5223.1974.tb01343.x
10.1073/pnas.76.6.2799
10.1111/j.1432-1033.1971.tb01290.x
10.1002/jcp.1040920310
10.1073/pnas.56.5.1520
{'key': 'e_1_2_1_28_1', 'first-page': '309', 'volume-title': 'The Cell Cycle and Cancer', 'author': 'Tobey R. A.', 'year': '1971'} / The Cell Cycle and Cancer by Tobey R. A. (1971)
10.1038/bjc.1974.48
10.1016/S0006-291X(76)80294-X

Dates

Type	When
Created	20 years, 6 months ago (Feb. 26, 2005, 10:52 a.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 4:37 a.m.)
Indexed	1 year, 2 months ago (June 28, 2024, 10:15 p.m.)
Issued	43 years, 10 months ago (Nov. 1, 1981)
Published	43 years, 10 months ago (Nov. 1, 1981)
Published Online	20 years, 7 months ago (Feb. 4, 2005)
Published Print	43 years, 10 months ago (Nov. 1, 1981)

Funders 0

None

BibTeX

@article{Nishimoto_1981, title={The synthesis of protein(S) for chromosome condensation may be regulated by a post‐transcriptional mechanism}, volume={109}, ISSN={1097-4652}, url={http://dx.doi.org/10.1002/jcp.1041090213}, DOI={10.1002/jcp.1041090213}, number={2}, journal={Journal of Cellular Physiology}, publisher={Wiley}, author={Nishimoto, Takeharu and Ishida, Ryoji and Ajiro, Kozo and Yamamoto, Susumu and Takahashi, Taijo}, year={1981}, month=nov, pages={299–308} }

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