DOI: 10.1002/jcp.1040980210. Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro

Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro

10.1002/jcp.1040980210

Crossref journal-article

Wiley

Journal of Cellular Physiology (311)

Abstract

AbstractFibroblasts were isolated from keloid, normal skin, and normal scar and maintained in tissue culture for four passages. Growth kinetics were the same for all groups on days 2 through 12. However, the rate of collagen synthesis per fibroblast was greater in keloid derived cells than any controls at all growth phases. Keloid fibroblasts have an autonomous capacity to synthesize collagen at a significantly increased level in vitro, which may explain in part why these lesions are characterized by increased collagen deposition.

Bibliography

Diegelmann, R. F., Cohen, I. K., & McCoy, B. J. (1979). Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro. Journal of Cellular Physiology, 98(2), 341â346. Portico.

Authors 3

Robert F. Diegelmann (first)
I. Kelman Cohen (additional)
Barbara J. McCoy (additional)

References 24 Referenced 172

10.1073/pnas.70.6.1753
10.1016/0003-9861(75)90031-4
{'key': 'e_1_2_1_4_1', 'first-page': '199', 'volume-title': 'The Ultrastructure of Collagen', 'author': 'Cohen I. K.', 'year': '1976'} / The Ultrastructure of Collagen by Cohen I. K. (1976)
{'key': 'e_1_2_1_5_1', 'first-page': '488', 'article-title': 'Collagen synthesis in human keloid and hypertrophic scar', 'volume': '22', 'author': 'Cohen I. K.', 'year': '1971', 'journal-title': 'Surg. Forum'} / Surg. Forum / Collagen synthesis in human keloid and hypertrophic scar by Cohen I. K. (1971)
10.1097/00006534-195909000-00001
10.1097/00006534-196002000-00001
10.1111/j.1365-2362.1975.tb00430.x
10.1016/0012-1606(72)90028-0
10.1016/S0021-9258(19)40644-3 / J. Biol. Chem. / Isolation and characterization of CNBr peptides of human [α(III)]3 collagen and tissue distribution of [α1(I)]2α 2 and [α1(III)]3 collagens by Epstein E. H. (1975)
10.1016/0014-4827(59)90010-2
10.3181/00379727-117-29551
10.1073/pnas.73.8.2909
10.1021/ja01652a059
10.1097/00006534-197102000-00006
10.1002/bjs.1800631024
10.1172/JCI107827
10.1126/science.150.3692.67
10.1097/00007611-197007000-00002
10.1021/bi00782a009
10.1016/0003-2697(62)90141-0
10.1002/ajpa.1330410107
10.1097/00006534-197602000-00014
{'key': 'e_1_2_1_24_1', 'first-page': '3', 'article-title': 'Receptors for complement and immunoglobulin on human and animal lymphoid cells', 'volume': '16', 'author': 'Shevach E. M.', 'year': '1973', 'journal-title': 'Transplant. Rev.'} / Transplant. Rev. / Receptors for complement and immunoglobulin on human and animal lymphoid cells by Shevach E. M. (1973)
10.1002/ijc.2910130207

Dates

Type	When
Created	20 years, 6 months ago (Feb. 26, 2005, 11:51 a.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 12:59 a.m.)
Indexed	4 weeks, 2 days ago (Aug. 3, 2025, 6:50 p.m.)
Issued	46 years, 7 months ago (Feb. 1, 1979)
Published	46 years, 7 months ago (Feb. 1, 1979)
Published Online	20 years, 6 months ago (Feb. 4, 2005)
Published Print	46 years, 7 months ago (Feb. 1, 1979)

Funders 0

None

BibTeX

@article{Diegelmann_1979, title={Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro}, volume={98}, ISSN={1097-4652}, url={http://dx.doi.org/10.1002/jcp.1040980210}, DOI={10.1002/jcp.1040980210}, number={2}, journal={Journal of Cellular Physiology}, publisher={Wiley}, author={Diegelmann, Robert F. and Cohen, I. Kelman and McCoy, Barbara J.}, year={1979}, month=feb, pages={341–346} }

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