DOI: 10.1002/jcp.1040920311. Coexpression of mutant and wild type protein kinase in lymphoma cells resistant to dibutyryl cyclic AMP

Coexpression of mutant and wild type protein kinase in lymphoma cells resistant to dibutyryl cyclic AMP

10.1002/jcp.1040920311

Crossref journal-article

Wiley

Journal of Cellular Physiology (311)

Abstract

AbstractA mutant clone resistnat to dibutyryl cyclic AMP was isolated from S49 mouse lymphoma cells. The mutant expressed a form of cyclic AMP‐dependent protein kinase distinguishable from wild type kinase by its decreased sensitivity to activation by cyclic AMP and its increased thermal lability. Hybrids formed between mutant and wild type cells were resistant to dibutyryl cyclic AMP and expresed both mutant and wild type activities in about equal amount. The parent mutant cells also appeared to express wild type kinase activity, but at a lower level. We conclude that wild type S49 cells have and expression two identical alleles for the regulatory subunit of protein kinase, one of which has undergone mutation in the mutant cells.

Bibliography

Lemaire, I., & Coffino, P. (1977). Coexpression of mutant and wild type protein kinase in lymphoma cells resistant to dibutyryl cyclic AMP. Journal of Cellular Physiology, 92(3), 437â445. Portico.

Authors 2

Irma Lemaire (first)
Philip Coffino (additional)

References 18 Referenced 18

{'key': 'e_1_2_1_2_1', 'first-page': '617', 'article-title': 'Cyclic AMP dependent protein kinase isozymes', 'volume': '34', 'author': 'Bechtel P. J.', 'year': '1975', 'journal-title': 'Fed. Proc.'} / Fed. Proc. / Cyclic AMP dependent protein kinase isozymes by Bechtel P. J. (1975)
10.1007/BF01542725
10.1002/jcp.1040790313
{'key': 'e_1_2_1_5_1', 'first-page': '669', 'volume-title': 'Recent Progress in Hormone Research', 'author': 'Coffino P.', 'year': '1976'} / Recent Progress in Hormone Research by Coffino P. (1976)
10.1002/jcp.1040850312
10.1073/pnas.72.3.878
10.1073/pnas.74.2.679
10.1038/205640a0
10.1073/pnas.72.12.5051
{'key': 'e_1_2_1_11_1', 'first-page': '177', 'article-title': 'Mouse myelomas and lymphomas in culture', 'volume': '78', 'author': 'Horibata K.', 'year': '1970', 'journal-title': 'J. Cell. Physiol.'} / J. Cell. Physiol. / Mouse myelomas and lymphomas in culture by Horibata K. (1970)
10.1016/S0021-9258(17)33548-2 / J. Biol. Chem. / α‐Amanitin resistance of RNA polymerase II in mutant Chinese hamster ovary cell lives by Ingles C. J. (1976)
10.1126/science.171770
10.1126/science.145.3633.709
10.1016/S0021-9258(19)52451-6
10.1016/S0006-291X(73)80006-3
10.1016/0092-8674(76)90249-X
10.1016/0092-8674(77)90025-3
10.1126/science.163.3872.1213

Dates

Type	When
Created	20 years, 6 months ago (Feb. 26, 2005, 12:09 p.m.)
Deposited	1 year, 9 months ago (Nov. 11, 2023, 10:41 p.m.)
Indexed	1 year, 9 months ago (Nov. 11, 2023, 11:10 p.m.)
Issued	47 years, 11 months ago (Sept. 1, 1977)
Published	47 years, 11 months ago (Sept. 1, 1977)
Published Online	20 years, 6 months ago (Feb. 4, 2005)
Published Print	47 years, 11 months ago (Sept. 1, 1977)

Funders 0

None

BibTeX

@article{Lemaire_1977, title={Coexpression of mutant and wild type protein kinase in lymphoma cells resistant to dibutyryl cyclic AMP}, volume={92}, ISSN={1097-4652}, url={http://dx.doi.org/10.1002/jcp.1040920311}, DOI={10.1002/jcp.1040920311}, number={3}, journal={Journal of Cellular Physiology}, publisher={Wiley}, author={Lemaire, Irma and Coffino, Philip}, year={1977}, month=sep, pages={437–445} }

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