DOI: 10.1002/jcp.1040790206. Expression of differentiated functions in hepatoma cell hybrids. II. Aldolase

Expression of differentiated functions in hepatoma cell hybrids. II. Aldolase

10.1002/jcp.1040790206

Crossref journal-article

Wiley

Journal of Cellular Physiology (311)

Abstract

AbstractA study of aldolases in rat hepatoma clones and subclones has revealed that they synthesize all three forms of aldolase monomers: A (the ubiquitous glycolytic isozyme), B (the form characteristic of the liver) and C, and that in vitro–in vivo passage results in a reversible modulation in aldolase A activity.Three kinds of somatic hybrids, between rat hepatoma cells and either mouse fibroblasts or rat epithelial cells, have been studied. In each case, aldolase B, found only in the hepatoma parent, was absent in the hybrid cells. The absence of aldolase B in the somatic hybrids seems not to be due to trivial factors (species differences, inactivation of all hepatoma aldolase genes, increase in ploidy or loss of chromosomes); it is concluded that extinction of this differentiated function of the hepatoma parent reflects a genetic regulatory phenomenon.

Bibliography

Bertolotti, R., & Weiss, M. C. (1972). Expression of differentiated functions in hepatoma cell hybrids. II. Aldolase. Journal of Cellular Physiology, 79(2), 211â223. Portico.

Authors 2

Roger Bertolotti (first)
Mary C. Weiss (additional)

References 56 Referenced 46

{'key': 'e_1_2_1_2_1', 'first-page': '2408', 'article-title': 'Fructokinase, triokinase, and aldolases in liver tumors of the rat', 'volume': '27', 'author': 'Adelman R. C.', 'year': '1967', 'journal-title': 'Cancer Res.'} / Cancer Res. / Fructokinase, triokinase, and aldolases in liver tumors of the rat by Adelman R. C. (1967)
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Dates

Type	When
Created	20 years, 6 months ago (Feb. 26, 2005, 1:24 p.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 6:54 a.m.)
Indexed	1 year, 9 months ago (Nov. 12, 2023, 7:10 a.m.)
Issued	53 years, 5 months ago (April 1, 1972)
Published	53 years, 5 months ago (April 1, 1972)
Published Online	20 years, 7 months ago (Feb. 4, 2005)
Published Print	53 years, 5 months ago (April 1, 1972)

Funders 0

None

BibTeX

@article{Bertolotti_1972, title={Expression of differentiated functions in hepatoma cell hybrids. II. Aldolase}, volume={79}, ISSN={1097-4652}, url={http://dx.doi.org/10.1002/jcp.1040790206}, DOI={10.1002/jcp.1040790206}, number={2}, journal={Journal of Cellular Physiology}, publisher={Wiley}, author={Bertolotti, Roger and Weiss, Mary C.}, year={1972}, month=apr, pages={211–223} }

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