DOI: 10.1002/jcb.24305. Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancer‐cell anchorage and shape

Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancer‐cell anchorage and shape

10.1002/jcb.24305

Crossref journal-article

Wiley

Journal of Cellular Biochemistry (311)

Abstract

AbstractSecond harmonic generation (SHG) multiphoton imaging can visualize fibrillar collagen in tissues. SHG has previously shown that fibrillar collagen is altered in various types of cancer. In the present study, in vivo high resolution SHG multi‐photon tomography in living mice was used to study the relationship between cancer cells and intratumor collagen fibrils. Using green fluorescent protein (GFP) to visualize cancer cells and SHG to image collagen, we demonstrated that collagen fibrils provide a scaffold for cancer cells to align themselves and acquire optimal shape. These results suggest a new paradigm for a stromal element of tumors: their role in maintaining anchorage and shape of cancer cells that may enable them to proliferate. J. Cell. Biochem. 114: 99–102, 2012. © 2012 Wiley Periodicals, Inc.

Bibliography

Uchugonova, A., Zhao, M., Weinigel, M., Zhang, Y., Bouvet, M., Hoffman, R. M., & KÃ¶nig, K. (2012). Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancerâcell anchorage and shape. Journal of Cellular Biochemistry, 114(1), 99â102. Portico.

Authors 7

Aisada Uchugonova (first)
Ming Zhao (additional)
Martin Weinigel (additional)
Yong Zhang (additional)
Michael Bouvet (additional)
Robert M. Hoffman (additional)
Karsten König (additional)

References 25 Referenced 35

10.1016/0092-8674(78)90347-1
10.1016/0092-8674(80)90473-0
10.4161/cc.5.16.3222
10.1038/nm879
10.1021/ac1032325
10.1039/b906310b
10.1016/0092-8674(78)90031-4
10.1016/0304-419X(75)90011-6
10.1038/273345a0
10.1038/ncb2548
10.1038/nrc1717
10.1038/nprot.2006.109
10.1038/nprot.2006.119
10.1038/nprot.2006.223
10.1016/j.semcancer.2008.03.016
10.1002/jbio.200710022
10.1117/1.1577349
10.1146/annurev.cellbio.22.010305.104315
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10.1073/pnas.052029099 / Proc Natl Acad Sci USA / Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model by Yang M (2002)

Dates

Type	When
Created	13 years ago (Aug. 6, 2012, 10:28 a.m.)
Deposited	1 year, 10 months ago (Oct. 18, 2023, 8:59 p.m.)
Indexed	1 year ago (Aug. 26, 2024, 11:10 a.m.)
Issued	12 years, 9 months ago (Nov. 14, 2012)
Published	12 years, 9 months ago (Nov. 14, 2012)
Published Online	12 years, 9 months ago (Nov. 14, 2012)
Published Print	12 years, 8 months ago (Jan. 1, 2013)

Funders 0

None

BibTeX

@article{Uchugonova_2012, title={Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancer‐cell anchorage and shape}, volume={114}, ISSN={1097-4644}, url={http://dx.doi.org/10.1002/jcb.24305}, DOI={10.1002/jcb.24305}, number={1}, journal={Journal of Cellular Biochemistry}, publisher={Wiley}, author={Uchugonova, Aisada and Zhao, Ming and Weinigel, Martin and Zhang, Yong and Bouvet, Michael and Hoffman, Robert M. and König, Karsten}, year={2012}, month=nov, pages={99–102} }

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