DOI: 10.1002/jcb.240560210. Triggeps and switches in a self‐assembling pore‐forming portein

Triggeps and switches in a self‐assembling pore‐forming portein

10.1002/jcb.240560210

Crossref journal-article

Wiley

Journal of Cellular Biochemistry (311)

Abstract

AbstractProtein engineering is being used to produce a collection of pore‐forming proteings with applications in biotechnology. Knowledge provided by investigations of the mechanism of self‐assembly of staphylococcal α‐hemolysin has allowed the desigl of genetically and chemically modified tariants of the protein with pore‐forming activities that can be triggered or switched mn‐and‐off by chemical, biochemical and physical inputs. Examples include α‐hemolysins that are activated by specific proteases and α‐hemolysins whose activity is controlled by divalent metal ions. These proteins have potential value in drug delivery as components of immunotoxils that aan be activated at the surfaces of target aells. Further applications are likely in improved encapsulation techniques for drugs, enzymes and cells.

Bibliography

Bayley, H. (1994). Triggeps and switches in a selfâassembling poreâforming portein. Journal of Cellular Biochemistry, 56(2), 177â182. Portico.

Authors 1

Hagan Bayley (first)

References 21 Referenced 28

10.1146/annurev.ph.55.030193.003543
10.1126/science.1648261
{'key': 'e_1_2_1_4_1', 'first-page': '241', 'article-title': 'Assembly of α‐hemolysil: A proteinaceous pore with potential applications in materials synthesis', 'volume': '292', 'author': 'Bayley H', 'year': '1993', 'journal-title': 'MRS Symp Proc'} / MRS Symp Proc / Assembly of α‐hemolysil: A proteinaceous pore with potential applications in materials synthesis by Bayley H (1993)
10.1128/iai.6.4.636-642.1972 / Infect Immun / Factors affecting interaction of staphylococcal alpha toxin with membranes by Bernheimer AW (1972)
10.1073/pnas.78.9.5475
10.1128/mr.55.4.733-751.1991
10.1016/0304-419X(90)90014-R
{'key': 'e_1_2_1_9_1', 'first-page': '1', 'article-title': 'The evolution of cancer research', 'volume': '1', 'author': 'Cairns J', 'year': '1989', 'journal-title': 'Cancer Cell'} / Cancer Cell / The evolution of cancer research by Cairns J (1989)
10.1016/S0021-9258(19)84902-5 / J Biol Chem / Introduction of a metal‐dependent regulatory switch into a enzyme by Corey DR (1989)
10.1016/0968-0004(92)90245-5
10.1007/978-1-4899-1630-3_4
10.1126/science.2218494
10.1016/0092-8674(91)90642-C
10.1126/science.2916125
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10.1146/annurev.bi.61.070192.001555
10.1016/0006-291X(91)90141-S
10.1002/jcb.240560209
10.1016/S0021-9258(19)36680-3 / J Biol Chem / Assembly of the oligomeric membrane pore formed by staphylococcal α‐hemolysin examined by truncation mutagenesis by Walker BJ (1992)
10.1093/protein/7.1.91
10.1016/S0021-9258(18)53531-6 / J Biol Chem / Staphylococal α‐hemolysil with overlaps, nicks and gaps in the glycine‐rich loop region by Walker BJ (1993)

Dates

Type	When
Created	20 years, 3 months ago (May 28, 2005, 5:47 p.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 9:18 p.m.)
Indexed	1 month, 2 weeks ago (July 20, 2025, 12:13 a.m.)
Issued	30 years, 11 months ago (Oct. 1, 1994)
Published	30 years, 11 months ago (Oct. 1, 1994)
Published Online	21 years, 6 months ago (Feb. 19, 2004)
Published Print	30 years, 11 months ago (Oct. 1, 1994)

Funders 0

None

BibTeX

@article{Bayley_1994, title={Triggeps and switches in a self‐assembling pore‐forming portein}, volume={56}, ISSN={1097-4644}, url={http://dx.doi.org/10.1002/jcb.240560210}, DOI={10.1002/jcb.240560210}, number={2}, journal={Journal of Cellular Biochemistry}, publisher={Wiley}, author={Bayley, Hagan}, year={1994}, month=oct, pages={177–182} }

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