DOI: 10.1002/jcb.240550113. Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II

Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II

10.1002/jcb.240550113

Crossref journal-article

Wiley

Journal of Cellular Biochemistry (311)

Abstract

AbstractFocal adhesion kinase (FAK) is a structurally unique nonreceptor protein‐tyrosine kinase that localizes to focal adhesion plaques. Regulation of its activity has been implicated in diverse signaling pathways, including those mediated by extracellular matrix/integrin interactions, G‐protein coupled receptors for mitogenic neuropeptides, and certain oncogene products. To gain evidence for specific processes in which FAK may be involved in vivo, a study was initiated to determine its expression pattern during mouse development. FAK expression was detected in early embryos and appeared to be distributed throughout all cell types at about the time of neurulation. Subsequent to neural tube closure, expression became particularly abundant in the developing vasculature. This included expression in the medial layer of arteries populated by smooth muscle cells. In vitro studies using cultured rat aortic vascular smooth muscle cells demonstrate that FAK phosphotyrosine content is dramatically elevated in response to plating cells onto the adhesive glycoprotein, fibronectin. Also, enhanced tyrosine phosphorylation of FAK is observed in these cells upon stimulation with the vasoconstrictor angiotensin II. Thus, in vascular smooth muscle cells, like fibroblasts, FAK appears to play a role in signaling mechanisms induced by extracellular matrix components as well as G‐protein coupled receptor agonists. The combined results of this study suggest that signaling through FAK may play an important role in blood vessel morphogenesis and function. © 1994 Wiley‐Liss, Inc.

Bibliography

Polte, T. R., Hanks, S. K., & Naftilan, A. J. (1994). Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II. Journal of Cellular Biochemistry, 55(1), 106â119. Portico.

Authors 3

Thomas R. Polte (first)
Steven K. Hanks (additional)
Allen J. Naftilan (additional)

References 51 Referenced 96

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10.1016/S0021-9258(18)41733-4 / J Biol Chem / Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in swiss 3T3 cells by Zachary I (1992)

Dates

Type	When
Created	20 years, 3 months ago (May 28, 2005, 5:39 p.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, 8:55 p.m.)
Indexed	2 months ago (July 2, 2025, 2:46 p.m.)
Issued	31 years, 4 months ago (May 1, 1994)
Published	31 years, 4 months ago (May 1, 1994)
Published Online	21 years, 6 months ago (Feb. 19, 2004)
Published Print	31 years, 4 months ago (May 1, 1994)

Funders 0

None

BibTeX

@article{Polte_1994, title={Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II}, volume={55}, ISSN={1097-4644}, url={http://dx.doi.org/10.1002/jcb.240550113}, DOI={10.1002/jcb.240550113}, number={1}, journal={Journal of Cellular Biochemistry}, publisher={Wiley}, author={Polte, Thomas R. and Hanks, Steven K. and Naftilan, Allen J.}, year={1994}, month=may, pages={106–119} }

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