DOI: 10.1002/jcb.240470405. The nucleus: A black box being opened

10.1002/jcb.240470405

Crossref journal-article

Wiley

Journal of Cellular Biochemistry (311)

Abstract

AbstractUntil recently our knowledge about the structural and functional organization of the cell nucleus was very limited. Recent technical developments in the field of ultrastrcutural analysis, combined with ongoing research on the properties of the nuclear matrix, give new insight into how the nucleus is structured. Two types of observations shape our ideas about nuclear organization. First, most nuclear functions (replication, transcription, RNA processing, and RNA transport) are highly localized within the nucleus, rather than diffusely distributed. Moreover, they are associated with the nuclear matrix. Second, chromatin is organized in discrete loops, bordered by nuclear matrix attachment sequences (MARs). Each loop may contain one or several genes. The arrangement of chromatin in loops has profound consequences for the regulation of gene expression.

Authors 3

Roel van Driel (first)
Bruno Humbel (additional)
Luitzen de Jong (additional)

References 64 Referenced 56

{'key': 'e_1_2_1_2_2', 'first-page': '337', 'volume': '44', 'author': 'Arroua ML', 'year': '1982', 'journal-title': 'Biol Cell'} / Biol Cell by Arroua ML (1982)
{'key': 'e_1_2_1_3_2', 'first-page': '235', 'volume': '50', 'author': 'Thiry M', 'year': '1989', 'journal-title': 'Eur J Cell Biol'} / Eur J Cell Biol by Thiry M (1989)
10.1016/0014-4827(86)90583-5
10.1083/jcb.108.1.1
10.1038/343437a0
10.1002/j.1460-2075.1991.tb07936.x
10.1073/pnas.87.1.147
{'key': 'e_1_2_1_9_2', 'first-page': '255', 'volume': '65', 'author': 'Fakan S', 'year': '1980', 'journal-title': 'Int Rev Cell Biol'} / Int Rev Cell Biol by Fakan S (1980)
10.1016/0092-8674(85)90177-1
{'key': 'e_1_2_1_11_2', 'first-page': '135', 'volume': '52', 'author': 'De Graaf A', 'year': '1990', 'journal-title': 'Eur J Cell Biol'} / Eur J Cell Biol by De Graaf A (1990)
{'key': 'e_1_2_1_12_2', 'first-page': '1', 'volume': '12', 'author': 'Dupuis‐Coin AM', 'year': '1986', 'journal-title': 'Methods Achiev Exp Pathol'} / Methods Achiev Exp Pathol by Dupuis‐Coin AM (1986)
10.1111/j.1365-2249.1991.tb05630.x
10.1016/0014-4827(91)90496-H
10.1083/jcb.112.5.785
10.1016/0092-8674(89)90924-0
10.1073/pnas.82.24.8527
10.1002/j.1460-2075.1986.tb04374.x
10.1093/nar/18.8.1965
10.1016/S0021-9258(19)75763-9
10.1016/0092-8674(80)90527-9
10.1002/j.1460-2075.1985.tb03719.x
10.1083/jcb.108.3.765
10.1021/bi00263a018
10.1083/jcb.112.6.1055
10.1515/9783110850260-004 / Recent Advances in Steroid Hormone Action by Barrack ER (1987)
10.1210/mend-4-9-1336
10.1038/306607a0
10.1042/bj2670385 / Biochem J by Ogata N (1990)
10.1021/bi00238a006
10.1111/j.1432-1033.1978.tb12188.x
10.1016/0092-8674(80)90156-7
10.1016/0092-8674(77)90280-X
10.1083/jcb.96.1.84
10.1002/j.1460-2075.1990.tb08144.x
{'key': 'e_1_2_1_36_2', 'first-page': '119', 'volume': '119', 'author': 'Gasser SM', 'year': '1989', 'journal-title': 'Int Rev of Cytol'} / Int Rev of Cytol by Gasser SM (1989)
10.1021/bi00219a015
10.1016/0092-8674(91)90214-J
10.1016/0092-8674(86)90761-0
10.1002/j.1460-2075.1988.tb02860.x
10.1021/bi00413a019
10.1016/S0021-9258(19)30066-3 / J Biol Chem by Levywilson B (1989)
10.1016/0092-8674(84)90208-3
10.1002/j.1460-2075.1988.tb03205.x
10.1128/MCB.10.5.2302
10.1038/341343a0
10.1083/jcb.100.5.1706
10.1073/pnas.82.12.4142
10.1242/jcs.1984.Supplement_1.9
10.1002/cyto.990110104
10.1126/science.2274784
10.1016/0309-1651(90)90014-P
10.1242/jcs.90.1.11
10.1016/0092-8674(88)90111-0
10.1016/0006-291X(74)90355-6
10.1007/BF00418244
10.1016/0168-9452(91)90215-T
10.1016/0014-4827(84)90208-8
10.1083/jcb.110.3.569
10.1007/978-1-4757-9604-9_5
PientaKJ GetzenbergRH CoffeyDS:CRC Reviews on Eukaryotic Gene Expression:355–385 1991.
10.1083/jcb.98.6.1973
10.1016/S0021-9258(19)39383-4 / J Biol Chem by Stuurman N (1990)
10.1073/pnas.85.1.121
10.1242/jcs.98.3.281 / J Cell Sci by Belgrader P (1991)

Dates

Type	When
Created	20 years, 2 months ago (May 28, 2005, 4:49 p.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 6:22 p.m.)
Indexed	1 year, 7 months ago (Jan. 15, 2024, 5:41 a.m.)
Issued	33 years, 8 months ago (Dec. 1, 1991)
Published	33 years, 8 months ago (Dec. 1, 1991)
Published Online	21 years, 6 months ago (Feb. 19, 2004)
Published Print	33 years, 8 months ago (Dec. 1, 1991)

Funders 0

None

BibTeX

@article{van_Driel_1991, title={The nucleus: A black box being opened}, volume={47}, ISSN={1097-4644}, url={http://dx.doi.org/10.1002/jcb.240470405}, DOI={10.1002/jcb.240470405}, number={4}, journal={Journal of Cellular Biochemistry}, publisher={Wiley}, author={van Driel, Roel and Humbel, Bruno and de Jong, Luitzen}, year={1991}, month=dec, pages={311–316} }

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