DOI: 10.1002/jcb.240440205. Iron regulation of ferritin gene expression

Iron regulation of ferritin gene expression

10.1002/jcb.240440205

Crossref journal-article

Wiley

Journal of Cellular Biochemistry (311)

Abstract

AbstractFerritin is a ubiquitous iron‐storage protein found in the cells of animals, plants, molds, and bacteria which it protects from toxic intracellular levels of iron. Ferritin stores iron within a hollow protein shell formed by subunits of two types, H and L. The 5′ untraslated regions of the two subunit mRNAs contain an almost indentical 28‐nucleotide sequence which regulates translation by binding to a specific cell sap protein. When cell iron level is low, this repressor protein obstructs trnslation of stored ferritin mRNAs, whereas increased iron levels release this protein, thus permitting extensive ferritin subunit synthesis to respond rapidly. Similar motifs in the 3′ untranslated region of transferrin receptor mRNA interact with this protein to regulate breakdown of the mRNA and thus change the receptor population. Finally, transcription of the H and L genes can be independently increased by iron and other factors. In the case of iron, synthesis of the L‐mRNA is increased preferentially since ferritin shells with a preponderance of L‐subunits store iron more efficiently. Thus regulation of ferritin synthesis at the translational and transcriptional levels and by transferrin receptor mRNA abudance at the level of breakdown provide a coordinate mechanism for protecting cells against the effects of excess iron.

Bibliography

Munro, H. N. (1990). Iron regulation of ferritin gene expression. Journal of Cellular Biochemistry, 44(2), 107â115. Portico.

Authors 1

Hamish N. Munro (first)

References 26 Referenced 39

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{'key': 'e_1_2_1_4_2', 'first-page': '91', 'volume-title': 'Adv Inorg Biochem', 'author': 'Eisenstein RS', 'year': '1990'} / Adv Inorg Biochem by Eisenstein RS (1990)
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Dates

Type	When
Created	20 years, 3 months ago (May 28, 2005, 4:35 p.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 2:50 p.m.)
Indexed	1 year ago (Aug. 8, 2024, 6:35 a.m.)
Issued	34 years, 11 months ago (Oct. 1, 1990)
Published	34 years, 11 months ago (Oct. 1, 1990)
Published Online	21 years, 6 months ago (Feb. 19, 2004)
Published Print	34 years, 11 months ago (Oct. 1, 1990)

Funders 0

None

BibTeX

@article{Munro_1990, title={Iron regulation of ferritin gene expression}, volume={44}, ISSN={1097-4644}, url={http://dx.doi.org/10.1002/jcb.240440205}, DOI={10.1002/jcb.240440205}, number={2}, journal={Journal of Cellular Biochemistry}, publisher={Wiley}, author={Munro, Hamish N.}, year={1990}, month=oct, pages={107–115} }

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