DOI: 10.1002/jcb.240370302. Specificity of the interaction between phosphatidylinositol 4,5‐bisphosphate and the profilin:actin complex

Specificity of the interaction between phosphatidylinositol 4,5‐bisphosphate and the profilin:actin complex

10.1002/jcb.240370302

Crossref journal-article

Wiley

Journal of Cellular Biochemistry (311)

Abstract

AbstractProfilactin, the profiling:actin complex, which is present in large amounts in extracts of many types of eukaryotic cells, appears to serve as the precursor of microfilaments. It was reported recently that profilactin interacts specifically with phosphatidylinositol 4,5‐bisphosphate (PtdIns(4,5)P2) (Lassing and Lindberg: Nature 314:472–474, 1985.) The present paper describes in detail the behaviour of profilactin and profilin in the presence of different types of phospholipids and neutral lipids under different conditions. PtdIns(4,5)P2 is the only phospholipid found so far which in the presence of 80 mM KC1 and at Ca2+ concentrations below 10−5 M effectively dissociates profilactin with the resulting polymerization of the actin. Phosphatidylinositol 4‐monophosphate exhibits some activity but phosphatidylinositol is inactive. Both calf spleen profilin and profilin from human platelets form stable complexes with PtdIns(4,5)P2 micelles. PtdIns(4,5)P2 is active also when incorporated together with other phospholipids in mixed vesicles.

Authors 2

Ingrid Lassing (first)
Uno Lindberg (additional)

References 33 Referenced 113

10.1007/BF00711795
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{'key': 'e_1_2_1_9_2', 'first-page': '80', 'volume': '34', 'author': 'Sheterline P', 'year': '1984', 'journal-title': 'Eur J Cell Bioi'} / Eur J Cell Bioi by Sheterline P (1984)
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10.1007/BF00712116
10.1016/0014-5793(78)80610-3
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{'key': 'e_1_2_1_23_2', 'first-page': '668', 'volume': '165', 'author': 'Hendrickson HS', 'year': '1969', 'journal-title': 'Ann NY Acad Sci'} / Ann NY Acad Sci by Hendrickson HS (1969)
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Dates

Type	When
Created	20 years, 7 months ago (Dec. 30, 2004, 10:19 a.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 10:23 a.m.)
Indexed	11 months, 1 week ago (Sept. 13, 2024, 1:45 p.m.)
Issued	37 years, 1 month ago (July 1, 1988)
Published	37 years, 1 month ago (July 1, 1988)
Published Online	21 years, 6 months ago (Feb. 19, 2004)
Published Print	37 years, 1 month ago (July 1, 1988)

Funders 0

None

BibTeX

@article{Lassing_1988, title={Specificity of the interaction between phosphatidylinositol 4,5‐bisphosphate and the profilin:actin complex}, volume={37}, ISSN={1097-4644}, url={http://dx.doi.org/10.1002/jcb.240370302}, DOI={10.1002/jcb.240370302}, number={3}, journal={Journal of Cellular Biochemistry}, publisher={Wiley}, author={Lassing, Ingrid and Lindberg, Uno}, year={1988}, month=jul, pages={255–267} }

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