DOI: 10.1002/jcb.10385. A unified model for the action of leptin on bone turnover

A unified model for the action of leptin on bone turnover

10.1002/jcb.10385

Crossref journal-article

Wiley

Journal of Cellular Biochemistry (311)

Abstract

AbstractLeptin has been advocated as a centrally acting factor responsible for inhibiting accumulation of bone mass. However, recent investigations unequivocally establish leptin as a local (autocrine) factor expressed by osteoblasts. Exogenously added leptin causes osteoblastic cell proliferation and differentiation, while also rendering osteoblasts more efficacious in terms of mineralization. Leptin acts as an anti‐apoptotic agent, and augments messages responsible for the remodelling of bone tissue, i.e., mRNAs for osteoprotegerin (OPG) and the interleukin IL‐6. Furthermore, leptin message is readily expressed in osteoblasts subjected to mechanical strain. In this respect, osteoblasts, which are unilaterally stretched proliferate and differentiate, a phenomenon being potentiated by exposure of the cells to differentiating humoral factors. This article discusses a unified model of dually acting leptin through the central nervous system and the mechanostat principle applied to osteoblasts. The proposed model may account for the finely tuned bone homeostasis maintained within rather narrow limits, depending on exposure to humoral factors and the prevailing mechanostat usage mode. © 2002 Wiley‐Liss, Inc.

Bibliography

Gordeladze, J. O., & Reseland, J. E. (2003). A unified model for the action of leptin on bone turnover. Journal of Cellular Biochemistry, 88(4), 706â712. Portico.

Authors 2

Jan O. Gordeladze (first)
Janne E. Reseland (additional)

References 33 Referenced 41

10.1210/jcem.87.3.8313 / J Clin Endocrinol Metab / Serum leptin level is a predictor of bone mineral density in postmenopausal women by Blain H (2002)
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10.1016/S0092-8674(00)81558-5
10.1126/science.289.5484.1501
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10.2106/00004623-200112000-00016 / J Bone Joint Surg Am / Brain and bone: Central regulation of bone mass. A new paradigm in skeletal biology by Haberland M (2001)
10.1093/clinchem/48.5.754 / Clin Chem / Changes in bone turnover in patients with anorexia nervosa during eleven weeks of inpatient dietary treatment by Heer M (2002)
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{'key': 'e_1_2_9_25_1', 'first-page': '528', 'article-title': 'Role of leptin in bone growth: central player or peripheral supporter?', 'volume': '25', 'author': 'Reseland JE', 'year': '2002', 'journal-title': 'FEBS Lett'} / FEBS Lett / Role of leptin in bone growth: central player or peripheral supporter? by Reseland JE (2002)
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Dates

Type	When
Created	22 years, 6 months ago (Feb. 7, 2003, 6:08 p.m.)
Deposited	1 year, 10 months ago (Oct. 9, 2023, 4:39 p.m.)
Indexed	1 year ago (Aug. 24, 2024, 9:54 p.m.)
Issued	22 years, 7 months ago (Jan. 13, 2003)
Published	22 years, 7 months ago (Jan. 13, 2003)
Published Online	22 years, 7 months ago (Jan. 13, 2003)
Published Print	22 years, 6 months ago (March 1, 2003)

Funders 0

None

BibTeX

@article{Gordeladze_2003, title={A unified model for the action of leptin on bone turnover}, volume={88}, ISSN={1097-4644}, url={http://dx.doi.org/10.1002/jcb.10385}, DOI={10.1002/jcb.10385}, number={4}, journal={Journal of Cellular Biochemistry}, publisher={Wiley}, author={Gordeladze, Jan O. and Reseland, Janne E.}, year={2003}, month=jan, pages={706–712} }

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